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Fatty Acid Profiles...
Fatty Acid Profiles in Smokers with Chronic Periodontitis
- Article/chapterEnglish2011
Publisher, publication year, extent ...
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2010-11-01
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SAGE Publications,2011
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LIBRIS-ID:oai:lup.lub.lu.se:d4cd9aa4-dd6c-466c-93fd-c4f5189bea4d
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https://lup.lub.lu.se/record/1791093URI
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https://doi.org/10.1177/0022034510380695DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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We hypothesized that tobacco smoke induces alterations to the 3-OH fatty acids present in lipid A in a manner consistent with a microflora of reduced inflammatory potential. Whole saliva samples and full-mouth clinical periodontal recordings were obtained from persons with (22 smokers; 15 nonsmokers) and without (14 smokers; 15 non-smokers) chronic periodontitis. Clear differences in the contributions of multiple saturated 3-OH fatty acid species were noted in the group with disease compared with healthy individuals. Increases in the long-chain fatty acids associated with anaerobic bacterial periodontopathogens, particularly 3-OH-C-i17.0 (146.7%, relative to controls), were apparent. Significant reductions in the 3-OH fatty acids associated with the consensus (high potency) enteric LPS structure (3-OH-C-12.0 and 3-OH-C-14.0; 33.3% and 15.8% reduction, respectively) were noted in smokers compared with non-smokers with chronic periodontitis. Thus, smoking is associated with specific structural alterations to the lipid-A-derived 3-OH fatty acid profile in saliva that are consistent with an oral microflora of reduced inflammatory potential. These findings provide much-needed mechanistic insight into the established clinical conundrum of increased infection with periodontal pathogens but reduced clinical inflammation in smokers.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Larsson, LennartLund University,Lunds universitet,Avdelningen för medicinsk mikrobiologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Medical Microbiology,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)mmb-lla
(author)
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Biyikoglu, B.
(author)
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Renaud, D. E.
(author)
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Bagaitkar, J.
(author)
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Scott, D. A.
(author)
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Avdelningen för medicinsk mikrobiologiInstitutionen för laboratoriemedicin
(creator_code:org_t)
Related titles
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In:Journal of Dental Research: SAGE Publications90:1, s. 47-520022-03451544-0591
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