Sökning: WFRF:(Purcell Shaun) >
Causal Association ...
Causal Association Between Subtypes of Excessive Daytime Sleepiness and Risk of Cardiovascular Diseases
-
- Goodman, Matthew O. (författare)
- Brigham and Women's Hospital / Harvard Medical School,Broad Institute
-
- Dashti, Hassan S. (författare)
- Broad Institute,Massachusetts General Hospital
-
- Lane, Jacqueline M. (författare)
- Massachusetts General Hospital,Brigham and Women's Hospital / Harvard Medical School,Broad Institute
-
visa fler...
-
- Windred, Daniel P. (författare)
- Monash University
-
- Burns, Angus (författare)
- Massachusetts General Hospital,Monash University,Broad Institute
-
- Jones, Samuel E. (författare)
- University of Exeter,University of Helsinki
-
- Sofer, Tamar (författare)
- Brigham and Women's Hospital / Harvard Medical School,Harvard University
-
- Purcell, Shaun M. (författare)
- Brigham and Women's Hospital / Harvard Medical School,Broad Institute
-
- Zhu, Xiaofeng (författare)
- Case Western Reserve University
-
- Ollila, Hanna M. (författare)
- Broad Institute,University of Helsinki,Massachusetts General Hospital
-
- Kyle, Simon D. (författare)
- University of Oxford
-
Spiegelhalder, Kai (författare)
-
- Peker, Yüksel, 1961 (författare)
- Lund University,Lunds universitet,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Lungmedicin, allergologi och palliativ medicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Respiratory Medicine, Allergology, and Palliative Medicine,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Brigham and Women's Hospital / Harvard Medical School,Sahlgrenska Academy,University of Pittsburgh
-
- Huang, Tianyi (författare)
- Brigham and Women's Hospital / Harvard Medical School
-
- Cain, Sean W. (författare)
- Monash University
-
- Phillips, Andrew J.K. (författare)
- Monash University
-
- Saxena, Richa (författare)
- Massachusetts General Hospital,Broad Institute
-
- Rutter, Martin K. (författare)
- University of Manchester,Manchester Academic Health Science Centre
-
- Redline, Susan (författare)
- Brigham and Women's Hospital / Harvard Medical School
-
- Wang, Heming (författare)
- Broad Institute,Brigham and Women's Hospital / Harvard Medical School
-
visa färre...
-
(creator_code:org_t)
- 2023
- 2023
- Engelska.
-
Ingår i: Journal of the American Heart Association. - 2047-9980. ; 12:24
- Relaterad länk:
-
http://dx.doi.org/10... (free)
-
visa fler...
-
https://gup.ub.gu.se...
-
https://doi.org/10.1...
-
https://lup.lub.lu.s...
-
visa färre...
Abstract
Ämnesord
Stäng
- BACKGROUND: Excessive daytime sleepiness (EDS), experienced in 10% to 20% of the population, has been associated with cardiovascular disease and death. However, the condition is heterogeneous and is prevalent in individuals having short and long sleep duration. We sought to clarify the relationship between sleep duration subtypes of EDS with cardiovascular outcomes, accounting for these subtypes. METHODS AND RESULTS: We defined 3 sleep duration subtypes of excessive daytime sleepiness: normal (6-9hours), short (<6hours), and long (>9hours), and compared these with a nonsleepy, normal-sleep-duration reference group. We analyzed their associations with incident myocardial infarction (MI) and stroke using medical records of 355901 UK Biobank participants and performed 2-sample Mendelian randomization for each outcome. Compared with healthy sleep, long-sleep EDS was associated with an 83% increased rate of MI (hazard ratio, 1.83 [95% CI, 1.21-2.77]) during 8.2-year median follow-up, adjusting for multiple health and sociodemographic factors. Mendelian randomization analysis provided supporting evidence of a causal role for a genetic long-sleep EDS subtype in MI (inverse-variance weighted β=1.995, P=0.001). In contrast, we did not find evidence that other subtypes of EDS were associated with incident MI or any associations with stroke (P>0.05). CONCLUSIONS: Our study suggests the previous evidence linking EDS with increased cardiovascular disease risk may be primarily driven by the effect of its long-sleep subtype on higher risk of MI. Underlying mechanisms remain to be investigated but may involve sleep irregularity and circadian disruption, suggesting a need for novel interventions in this population.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- cardiovascular diseases
- excessive daytime sleepiness subtypes
- Mendelian randomization
- prospective analysis
- sleep duration
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Goodman, Matthew ...
-
Dashti, Hassan S ...
-
Lane, Jacqueline ...
-
Windred, Daniel ...
-
Burns, Angus
-
Jones, Samuel E.
-
visa fler...
-
Sofer, Tamar
-
Purcell, Shaun M ...
-
Zhu, Xiaofeng
-
Ollila, Hanna M.
-
Kyle, Simon D.
-
Spiegelhalder, K ...
-
Peker, Yüksel, 1 ...
-
Huang, Tianyi
-
Cain, Sean W.
-
Phillips, Andrew ...
-
Saxena, Richa
-
Rutter, Martin K ...
-
Redline, Susan
-
Wang, Heming
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Kardiologi
- Artiklar i publikationen
-
Journal of the A ...
- Av lärosätet
-
Göteborgs universitet
-
Lunds universitet