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Striatal changes in...
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Owens-Walton, ConorAustralian National University
(author)
Striatal changes in Parkinson disease : An investigation of morphology, functional connectivity and their relationship to clinical symptoms
- Article/chapterEnglish2018
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LIBRIS-ID:oai:lup.lub.lu.se:d5489646-6f2e-48dd-877e-16f8ec89475f
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https://lup.lub.lu.se/record/d5489646-6f2e-48dd-877e-16f8ec89475fURI
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https://doi.org/10.1016/j.pscychresns.2018.03.004DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:138073582URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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We sought to investigate morphological and resting state functional connectivity changes to the striatal nuclei in Parkinson disease (PD) and examine whether changes were associated with measures of clinical function. Striatal nuclei were manually segmented on 3T-T1 weighted MRI scans of 74 PD participants and 27 control subjects, quantitatively analysed for volume, shape and also functional connectivity using functional MRI data. Bilateral caudate nuclei and putamen volumes were significantly reduced in the PD cohort compared to controls. When looking at left and right hemispheres, the PD cohort had significantly smaller left caudate nucleus and right putamen volumes compared to controls. A significant correlation was found between greater atrophy of the caudate nucleus and poorer cognitive function, and between greater atrophy of the putamen and more severe motor symptoms. Resting-state functional MRI analysis revealed altered functional connectivity of the striatal structures in the PD group. This research demonstrates that PD involves atrophic changes to the caudate nucleus and putamen that are linked to clinical dysfunction. Our work reveals important information about a key structure-function relationship in the brain and provides support for caudate nucleus and putamen atrophy as neuroimaging biomeasures in PD.
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Jakabek, DavidUniversity of Wollongong
(author)
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Li, XiaozhenKarolinska Institute,Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups(Swepub:lu)xi3641li
(author)
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Wilkes, Fiona A.Australian National University
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Walterfang, MarkUniversity of Melbourne,Royal Melbourne Hospital
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Velakoulis, DennisRoyal Melbourne Hospital
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van Westen, DanielleLund University,Lunds universitet,Diagnostisk radiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neuroradiologi,Forskargrupper vid Lunds universitet,Diagnostic Radiology, (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Neuroradiology,Lund University Research Groups,Skåne University Hospital(Swepub:lu)ront-dva
(author)
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Looi, Jeffrey C.L.Australian National University,Royal Melbourne Hospital
(author)
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Hansson, OskarLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital(Swepub:lu)mphy-ohn
(author)
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Australian National UniversityUniversity of Wollongong
(creator_code:org_t)
Related titles
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In:Psychiatry Research - Neuroimaging: Elsevier BV275, s. 5-130925-49271872-7506
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