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Streptococcal Endo-...
Streptococcal Endo-β-N-Acetylglucosaminidase Suppresses Antibody-Mediated Inflammation In Vivo
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- Nandakumar, Kutty Selva, 1965- (author)
- Karolinska Institutet,Southern Medical University, Guangzhou, China; Karolinska Institute, Stockholm, Sweden
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- Collin, Mattias (author)
- Lund University,Lunds universitet,Infektionsmedicin,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Infektion och immunmodulering,Forskargrupper vid Lunds universitet,Infection Medicine (BMC),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Infection and immunomodulation,Lund University Research Groups,Lund University, Lund, Sweden
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- Happonen, Kaisa E. (author)
- Lund University, Lund, Sweden; Salk Institute for Biological Studies, La Jolla, CA, United States
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- Lundström, Susanna L. (author)
- Karolinska Institutet,Karolinska Institute, Stockholm, Sweden
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- Croxford, Allyson M. (author)
- Monash University, Clayton, VIC, Australia
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- Xu, Bingze (author)
- Karolinska Institutet,Karolinska Institute, Stockholm, Sweden
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- Zubarev, Roman A. (author)
- Karolinska Institutet,Karolinska Institute, Stockholm, Sweden
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- Rowley, Merrill J. (author)
- Monash University, Clayton, VIC, Australia
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- Blom, Anna M. (author)
- Lund University,Lunds universitet,Proteinkemi, Malmö,Forskargrupper vid Lunds universitet,Protein Chemistry, Malmö,Lund University Research Groups,Lund University, Lund, Sweden
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- Kjellman, Christian (author)
- Hansa Medical AB, Lund, Sweden
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- Holmdahl, Rikard (author)
- Karolinska Institutet,Southern Medical University, Guangzhou, China; Karolinska Institute, Stockholm, Sweden
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(creator_code:org_t)
- 2018-07-16
- 2018
- English.
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In: Frontiers in Immunology. - : Frontiers Media SA. - 1664-3224. ; 9
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Abstract
Subject headings
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- Endo-β-N-acetylglucosaminidase (EndoS) is a family 18 glycosyl hydrolase secreted by Streptococcus pyogenes. Recombinant EndoS hydrolyzes the β-1,4-di-N-acetylchitobiose core of the N-linked complex type glycan on the asparagine 297 of the γ-chains of IgG. Here, we report that EndoS and IgG hydrolyzed by EndoS induced suppression of local immune complex (IC)-mediated arthritis. A small amount (1 µg given i.v. to a mouse) of EndoS was sufficient to inhibit IgG-mediated arthritis in mice. The presence of EndoS disturbed larger IC lattice formation both in vitro and in vivo, as visualized with anti-C3b staining. Neither complement binding in vitro nor antigen-antibody binding per se were affected. Thus, EndoS could potentially be used for treating patients with IC-mediated pathology.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Keyword
- arthritis
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Nandakumar, Kutt ...
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Collin, Mattias
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Happonen, Kaisa ...
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Lundström, Susan ...
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Croxford, Allyso ...
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Xu, Bingze
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Zubarev, Roman A ...
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Rowley, Merrill ...
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Blom, Anna M.
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Kjellman, Christ ...
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Holmdahl, Rikard
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Immunology in th ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Rheumatology and ...
- Articles in the publication
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Frontiers in Imm ...
- By the university
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Lund University
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Karolinska Institutet
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Halmstad University