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Brief Report : IRF4...
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López-Isac, ElenaCSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
(author)
Brief Report : IRF4 Newly Identified as a Common Susceptibility Locus for Systemic Sclerosis and Rheumatoid Arthritis in a Cross-Disease Meta-Analysis of Genome-Wide Association Studies
- Article/chapterEnglish2016
Publisher, publication year, extent ...
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2016-08-25
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Wiley,2016
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7 s.
Numbers
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LIBRIS-ID:oai:lup.lub.lu.se:d5fa7c4f-87c1-4abe-b5d1-84993d4eaac8
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https://lup.lub.lu.se/record/d5fa7c4f-87c1-4abe-b5d1-84993d4eaac8URI
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https://doi.org/10.1002/art.39730DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:134219295URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Objective: Systemic sclerosis (SSc) and rheumatoid arthritis (RA) are autoimmune diseases that have similar clinical and immunologic characteristics. To date, several shared SSc–RA genetic loci have been identified independently. The aim of the current study was to systematically search for new common SSc–RA loci through an interdisease meta–genome-wide association (meta-GWAS) strategy. Methods: The study was designed as a meta-analysis combining GWAS data sets of patients with SSc and patients with RA, using a strategy that allowed identification of loci with both same-direction and opposite-direction allelic effects. The top single-nucleotide polymorphisms were followed up in independent SSc and RA case–control cohorts. This allowed an increase in the sample size to a total of 8,830 patients with SSc, 16,870 patients with RA, and 43,393 healthy controls. Results: This cross-disease meta-analysis of the GWAS data sets identified several loci with nominal association signals (P < 5 × 10−6) that also showed evidence of association in the disease-specific GWAS scans. These loci included several genomic regions not previously reported as shared loci, as well as several risk factors that were previously found to be associated with both diseases. Follow-up analyses of the putatively new SSc–RA loci identified IRF4 as a shared risk factor for these 2 diseases (Pcombined = 3.29 × 10−12). Analysis of the biologic relevance of the known SSc–RA shared loci identified the type I interferon and interleukin-12 signaling pathways as the main common etiologic factors. Conclusion: This study identified a novel shared locus, IRF4, for the risk of SSc and RA, and highlighted the usefulness of a cross-disease GWAS meta-analysis strategy in the identification of common risk loci.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Martín, Jose EzequielCSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
(author)
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Assassi, ShervinUniversity of Texas
(author)
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Simeón, Carmen P.Vall d'Hebron University Hospital
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Carreira, Patricia12 de Octubre University Hospital,University Medical Center Utrecht
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Ortego-Centeno, NorbertoHospital Clínico Universitario San Cecilio
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Freire, MaykaUniversity of Vigo,CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
(author)
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Beltrán, EmmaValencia University Hospital,CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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Narváez, JavierBellvitge University Hospital-IDIBELL,CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
(author)
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Alegre-Sancho, Juan J.Hospital Universitario Doctor Peset,CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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Fernández-Gutiérrez, BenjamínHospital Clinico San Carlos de Madrid
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Balsa, AlejandroUniversity Hospital La Paz
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Ortiz, Ana M.Hospital Universitario de la Princesa
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González-Gay, Miguel A.University of Cantabria
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Beretta, LorenzoMaggiore Hospital Policlinico
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Santaniello, AlessandroMaggiore Hospital Policlinico
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Bellocchi, ChiaraMaggiore Hospital Policlinico
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Lunardi, ClaudioUniversity of Verona
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Moroncini, GianlucaMarche Polytechnic University
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Gabrielli, ArmandoMarche Polytechnic University
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Witte, TorstenHannover Medical School
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Hunzelmann, NicolasUniversity of Cologne
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Distler, Jörg H WFriedrich-Alexander University Erlangen-Nürnberg
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Riekemasten, GabriellaBritish Columbia Children's Hospital
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van der Helm-van Mil, Annette H.Leiden University Medical Centre
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de Vries-Bouwstra, JeskaLeiden University Medical Centre
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Magro-Checa, CesarLeiden University Medical Centre
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Voskuyl, Alexandre E.Amsterdam UMC - Vrije Universiteit Amsterdam
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Vonk, Madelon C.Radboud University Nijmegen
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Molberg, ØyvindUniversity of Oslo
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Merriman, TonyUniversity of Otago
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Hesselstrand, RogerLund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Hjärt-lungsjukdom - information, stöd och bemötande,Forskargrupper vid Lunds universitet,Forskargruppen för systemisk skleros, Lund,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Cardiopulmonary disease - information, support and reception,Lund University Research Groups,Lund Systemic Sclerosis Research Group(Swepub:lu)reum-rhe
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Nordin, AnnikaKarolinska Institutet,Karolinska University Hospital
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Padyukov, LeonidKarolinska Institutet,Karolinska University Hospital
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Herrick, ArianeUniversity of Manchester
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Eyre, SteveUniversity of Manchester
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Koeleman, Bobby P CUniversity Medical Center Utrecht
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Denton, Christopher P.University College London
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Fonseca, CarmenUniversity College London
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Radstake, Timothy R D JUniversity Medical Center Utrecht,CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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Worthington, JaneUniversity of Manchester
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Mayes, Maureen D.University of Texas
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Martín, JavierCSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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Ríos, RaquelCSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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Callejas, Jose LuisCSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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Hitos, José Antonio VargasCSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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Portales, Rosa GarcíaCSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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Camps, María TeresaCSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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Fernández-Nebro, AntonioCSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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González-Escribano, María F.CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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García-Hernández, Francisco JoséCSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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Castillo, Ma JesúsCSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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Ángeles Aguirre, MaCSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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Gómez-Gracia, InmaculadaCSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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Rodríguez-Rodríguez, LuisCSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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Peña, Paloma García de laCSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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Vicente, EstherCSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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Andreu, José LuisCSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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de Castro, Mónica FernándezCSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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López-Longo, Francisco JavierCSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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Martínez, LinaCSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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Fonollosa, VicenteCSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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Guillén, AlfredoCSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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Castellví, IvánCSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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Espinosa, GerardCSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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Tolosa, CarlosCSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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Pros, AnnaCSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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Carballeira, Mónica RodríguezCSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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Narváez, Francisco JavierCSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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Rivas, Manel RubioCSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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Ortiz-Santamaría, VeraCSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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Madroñero, Ana BelénCSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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Díaz, BernardinoCSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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Trapiella, LuisCSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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Sousa, AdriánCSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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Egurbide, María VictoriaCSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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Mateo, Patricia FanloCSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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Sáez-Comet, LuisCSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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Díaz, FedericoCSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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Hernández, VanesaCSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
(author)
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Beltrán, EmmaCSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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Román-Ivorra, José AndrésCSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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Grau, ElenaCSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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Alegre-Sancho, Juan JoséCSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
(author)
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Blanco García, Francisco J.CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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Oreiro, NatividadCSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)University of Texas
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In:Arthritis & Rheumatology: Wiley68:9, s. 2338-23442326-51912326-5205
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López-Isac, Elen ...
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Martín, Jose Eze ...
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Assassi, Shervin
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Simeón, Carmen P ...
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Carreira, Patric ...
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Ortego-Centeno, ...
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Freire, Mayka
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Balsa, Alejandro
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Ortiz, Ana M.
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González-Gay, Mi ...
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Beretta, Lorenzo
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Santaniello, Ale ...
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Bellocchi, Chiar ...
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Lunardi, Claudio
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Moroncini, Gianl ...
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Gabrielli, Arman ...
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Witte, Torsten
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Magro-Checa, Ces ...
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Voskuyl, Alexand ...
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Vonk, Madelon C.
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Molberg, Øyvind
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Merriman, Tony
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Hesselstrand, Ro ...
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Nordin, Annika
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Padyukov, Leonid
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Herrick, Ariane
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Eyre, Steve
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Koeleman, Bobby ...
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Fonseca, Carmen
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Radstake, Timoth ...
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Worthington, Jan ...
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Mayes, Maureen D ...
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Martín, Javier
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Ríos, Raquel
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Callejas, Jose L ...
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Portales, Rosa G ...
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Camps, María Ter ...
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Fernández-Nebro, ...
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Peña, Paloma Gar ...
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Vicente, Esther
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Andreu, José Lui ...
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de Castro, Mónic ...
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López-Longo, Fra ...
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Martínez, Lina
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Fonollosa, Vicen ...
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Guillén, Alfredo
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Castellví, Iván
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Espinosa, Gerard
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Tolosa, Carlos
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Pros, Anna
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Carballeira, Món ...
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Narváez, Francis ...
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Rivas, Manel Rub ...
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Ortiz-Santamaría ...
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Díaz, Bernardino
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Trapiella, Luis
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Sousa, Adrián
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Egurbide, María ...
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Mateo, Patricia ...
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Sáez-Comet, Luis
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Díaz, Federico
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Hernández, Vanes ...
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Grau, Elena
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Alegre-Sancho, J ...
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