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Brief Report : IRF4...
Brief Report : IRF4 Newly Identified as a Common Susceptibility Locus for Systemic Sclerosis and Rheumatoid Arthritis in a Cross-Disease Meta-Analysis of Genome-Wide Association Studies
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- López-Isac, Elena (author)
- CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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- Martín, Jose Ezequiel (author)
- CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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- Assassi, Shervin (author)
- University of Texas
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show more...
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- Simeón, Carmen P. (author)
- Vall d'Hebron University Hospital
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- Carreira, Patricia (author)
- 12 de Octubre University Hospital,University Medical Center Utrecht
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- Ortego-Centeno, Norberto (author)
- Hospital Clínico Universitario San Cecilio
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- Freire, Mayka (author)
- University of Vigo,CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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- Beltrán, Emma (author)
- Valencia University Hospital,CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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- Narváez, Javier (author)
- Bellvitge University Hospital-IDIBELL,CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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- Alegre-Sancho, Juan J. (author)
- Hospital Universitario Doctor Peset,CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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- Fernández-Gutiérrez, Benjamín (author)
- Hospital Clinico San Carlos de Madrid
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- Balsa, Alejandro (author)
- University Hospital La Paz
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- Ortiz, Ana M. (author)
- Hospital Universitario de la Princesa
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- González-Gay, Miguel A. (author)
- University of Cantabria
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- Beretta, Lorenzo (author)
- Maggiore Hospital Policlinico
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- Santaniello, Alessandro (author)
- Maggiore Hospital Policlinico
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- Bellocchi, Chiara (author)
- Maggiore Hospital Policlinico
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- Lunardi, Claudio (author)
- University of Verona
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- Moroncini, Gianluca (author)
- Marche Polytechnic University
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- Gabrielli, Armando (author)
- Marche Polytechnic University
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- Witte, Torsten (author)
- Hannover Medical School
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- Hunzelmann, Nicolas (author)
- University of Cologne
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- Distler, Jörg H W (author)
- Friedrich-Alexander University Erlangen-Nürnberg
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- Riekemasten, Gabriella (author)
- British Columbia Children's Hospital
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- van der Helm-van Mil, Annette H. (author)
- Leiden University Medical Centre
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- de Vries-Bouwstra, Jeska (author)
- Leiden University Medical Centre
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- Magro-Checa, Cesar (author)
- Leiden University Medical Centre
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- Voskuyl, Alexandre E. (author)
- Amsterdam UMC - Vrije Universiteit Amsterdam
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- Vonk, Madelon C. (author)
- Radboud University Nijmegen
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- Molberg, Øyvind (author)
- University of Oslo
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- Merriman, Tony (author)
- University of Otago
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- Hesselstrand, Roger (author)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Hjärt-lungsjukdom - information, stöd och bemötande,Forskargrupper vid Lunds universitet,Forskargruppen för systemisk skleros, Lund,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Cardiopulmonary disease - information, support and reception,Lund University Research Groups,Lund Systemic Sclerosis Research Group
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- Nordin, Annika (author)
- Karolinska Institutet,Karolinska University Hospital
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- Padyukov, Leonid (author)
- Karolinska Institutet,Karolinska University Hospital
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- Herrick, Ariane (author)
- University of Manchester
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- Eyre, Steve (author)
- University of Manchester
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- Koeleman, Bobby P C (author)
- University Medical Center Utrecht
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- Denton, Christopher P. (author)
- University College London
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- Fonseca, Carmen (author)
- University College London
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- Radstake, Timothy R D J (author)
- University Medical Center Utrecht,CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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- Worthington, Jane (author)
- University of Manchester
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- Mayes, Maureen D. (author)
- University of Texas
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- Martín, Javier (author)
- CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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- Ríos, Raquel (author)
- CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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- Callejas, Jose Luis (author)
- CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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- Hitos, José Antonio Vargas (author)
- CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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- Portales, Rosa García (author)
- CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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- Camps, María Teresa (author)
- CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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- Fernández-Nebro, Antonio (author)
- CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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- González-Escribano, María F. (author)
- CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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- García-Hernández, Francisco José (author)
- CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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- Castillo, Ma Jesús (author)
- CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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- Ángeles Aguirre, Ma (author)
- CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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- Gómez-Gracia, Inmaculada (author)
- CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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- Rodríguez-Rodríguez, Luis (author)
- CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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- Peña, Paloma García de la (author)
- CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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- Vicente, Esther (author)
- CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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- Andreu, José Luis (author)
- CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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- de Castro, Mónica Fernández (author)
- CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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- López-Longo, Francisco Javier (author)
- CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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- Martínez, Lina (author)
- CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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- Fonollosa, Vicente (author)
- CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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- Guillén, Alfredo (author)
- CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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- Castellví, Iván (author)
- CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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- Espinosa, Gerard (author)
- CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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- Tolosa, Carlos (author)
- CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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- Pros, Anna (author)
- CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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- Carballeira, Mónica Rodríguez (author)
- CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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- Narváez, Francisco Javier (author)
- CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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- Rivas, Manel Rubio (author)
- CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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- Ortiz-Santamaría, Vera (author)
- CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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- Madroñero, Ana Belén (author)
- CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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- Díaz, Bernardino (author)
- CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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- Trapiella, Luis (author)
- CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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- Sousa, Adrián (author)
- CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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- Egurbide, María Victoria (author)
- CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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- Mateo, Patricia Fanlo (author)
- CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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- Sáez-Comet, Luis (author)
- CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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- Díaz, Federico (author)
- CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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- Hernández, Vanesa (author)
- CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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- Beltrán, Emma (author)
- CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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- Román-Ivorra, José Andrés (author)
- CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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- Grau, Elena (author)
- CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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- Alegre-Sancho, Juan José (author)
- CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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- Blanco García, Francisco J. (author)
- CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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- Oreiro, Natividad (author)
- CSIC Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN)
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(creator_code:org_t)
- 2016-08-25
- 2016
- English 7 s.
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In: Arthritis & Rheumatology. - : Wiley. - 2326-5191 .- 2326-5205. ; 68:9, s. 2338-2344
- Related links:
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http://dx.doi.org/10...
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https://onlinelibrar...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Objective: Systemic sclerosis (SSc) and rheumatoid arthritis (RA) are autoimmune diseases that have similar clinical and immunologic characteristics. To date, several shared SSc–RA genetic loci have been identified independently. The aim of the current study was to systematically search for new common SSc–RA loci through an interdisease meta–genome-wide association (meta-GWAS) strategy. Methods: The study was designed as a meta-analysis combining GWAS data sets of patients with SSc and patients with RA, using a strategy that allowed identification of loci with both same-direction and opposite-direction allelic effects. The top single-nucleotide polymorphisms were followed up in independent SSc and RA case–control cohorts. This allowed an increase in the sample size to a total of 8,830 patients with SSc, 16,870 patients with RA, and 43,393 healthy controls. Results: This cross-disease meta-analysis of the GWAS data sets identified several loci with nominal association signals (P < 5 × 10−6) that also showed evidence of association in the disease-specific GWAS scans. These loci included several genomic regions not previously reported as shared loci, as well as several risk factors that were previously found to be associated with both diseases. Follow-up analyses of the putatively new SSc–RA loci identified IRF4 as a shared risk factor for these 2 diseases (Pcombined = 3.29 × 10−12). Analysis of the biologic relevance of the known SSc–RA shared loci identified the type I interferon and interleukin-12 signaling pathways as the main common etiologic factors. Conclusion: This study identified a novel shared locus, IRF4, for the risk of SSc and RA, and highlighted the usefulness of a cross-disease GWAS meta-analysis strategy in the identification of common risk loci.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Keyword
- GWAS
- Rheumatoid Arthritis
- IRF4
- SYSTEMIC SCLEROSIS
Publication and Content Type
- art (subject category)
- ref (subject category)
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López-Isac, Elen ...
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Martín, Jose Eze ...
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Assassi, Shervin
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Simeón, Carmen P ...
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Carreira, Patric ...
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Ortego-Centeno, ...
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Freire, Mayka
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Beltrán, Emma
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Narváez, Javier
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Alegre-Sancho, J ...
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Fernández-Gutiér ...
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Balsa, Alejandro
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Ortiz, Ana M.
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González-Gay, Mi ...
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Beretta, Lorenzo
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Santaniello, Ale ...
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Bellocchi, Chiar ...
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Lunardi, Claudio
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Moroncini, Gianl ...
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Gabrielli, Arman ...
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Witte, Torsten
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Hunzelmann, Nico ...
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Distler, Jörg H ...
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Riekemasten, Gab ...
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van der Helm-van ...
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de Vries-Bouwstr ...
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Magro-Checa, Ces ...
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Voskuyl, Alexand ...
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Vonk, Madelon C.
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Molberg, Øyvind
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Merriman, Tony
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Hesselstrand, Ro ...
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Nordin, Annika
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Padyukov, Leonid
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Herrick, Ariane
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Eyre, Steve
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Koeleman, Bobby ...
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Denton, Christop ...
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Fonseca, Carmen
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Radstake, Timoth ...
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Worthington, Jan ...
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Mayes, Maureen D ...
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Martín, Javier
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Ríos, Raquel
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Callejas, Jose L ...
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Hitos, José Anto ...
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Portales, Rosa G ...
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Camps, María Ter ...
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Fernández-Nebro, ...
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González-Escriba ...
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García-Hernández ...
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Castillo, Ma Jes ...
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Ángeles Aguirre, ...
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Gómez-Gracia, In ...
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Rodríguez-Rodríg ...
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Peña, Paloma Gar ...
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Vicente, Esther
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Andreu, José Lui ...
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de Castro, Mónic ...
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López-Longo, Fra ...
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Martínez, Lina
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Fonollosa, Vicen ...
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Guillén, Alfredo
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Castellví, Iván
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Espinosa, Gerard
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Tolosa, Carlos
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Pros, Anna
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Carballeira, Món ...
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Narváez, Francis ...
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Rivas, Manel Rub ...
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Ortiz-Santamaría ...
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Madroñero, Ana B ...
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Díaz, Bernardino
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Trapiella, Luis
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Sousa, Adrián
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Egurbide, María ...
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Mateo, Patricia ...
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Sáez-Comet, Luis
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Díaz, Federico
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Hernández, Vanes ...
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Román-Ivorra, Jo ...
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Grau, Elena
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Alegre-Sancho, J ...
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Blanco García, F ...
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Oreiro, Nativida ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Rheumatology and ...
- Articles in the publication
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Arthritis & Rheu ...
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Lund University
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Karolinska Institutet