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- Allodji, Rodrigue S.University of Paris-Saclay,University of Birmingham,University of Abomey Calavi (UAC) (författare)
Risk of subsequent primary leukaemias among 69,460 five-year survivors of childhood cancer diagnosed from 1940 to 2008 in Europe: A cohort study within PanCareSurFup
- Artikel/kapitelEngelska2019
Förlag, utgivningsår, omfång ...
- Elsevier BV,2019
- 13 s.
Nummerbeteckningar
- LIBRIS-ID:oai:lup.lub.lu.se:d7337444-f136-4736-b526-5879f9b50248
- https://lup.lub.lu.se/record/d7337444-f136-4736-b526-5879f9b50248URI
- https://doi.org/10.1016/j.ejca.2019.05.013DOI
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- Språk:engelska
- Sammanfattning på:engelska
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- Background: Survivors of childhood cancers are at risk of developing subsequent primary leukaemias (SPLs), but the long-term risks beyond 20 years of treatment are still unclear. We investigated the risk of SPLs in five-year childhood cancer survivors using a large-scale pan-European (PanCareSurFup) cohort and evaluated variations in the risk by cancer and demographic factors. Methods: This largest-ever assembled cohort comprises 69,460 five-year childhood cancer survivors from 12 European countries. Standardised incidence ratios (SIRs) and absolute excess risks (AERs) were calculated. Results: One hundred fifteen survivors developed an SPL including 86 myeloid leukaemias (subsequent primary myeloid leukaemias [SPMLs]), 17 lymphoid leukaemias and 12 other types of leukaemias; of these SPLs, 31 (27%) occurred beyond 20 years from the first childhood cancer diagnosis. Compared with the general population, childhood cancer survivors had a fourfold increased risk (SIR = 3.7, 95% confidence interval [CI]: 3.1 to 4.5) of developing leukaemia, and eight leukaemias per 100,000 person-years (AER = 7.5, 95% CI: 6.0 to 9.2) occurred in excess of that expected. The risks remained significantly elevated beyond 20 years from the first primary malignancy (SIR = 2.4, 95% CI: 1.6 to 3.4). Overall, the risk ratio for SPML (SIR = 5.8, 95% CI: 4.6 to 7.1) was higher than that for other SPLs. Conclusions: We demonstrate that beyond 20 years after childhood cancer diagnosis, survivors experience an increased risk for SPLs compared with that expected from the general population. Our findings highlight the need for awareness by survivors and their healthcare providers for potential risk related to SPL. © 2019 Elsevier Ltd
Ämnesord och genrebeteckningar
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Hälsovetenskap Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Health Sciences Public Health, Global Health, Social Medicine and Epidemiology hsv//eng
- Childhood cancer survivors
- Lymphoid leukaemias
- Myeloid leukaemias
- Second cancers
- Subsequent primary leukaemia
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Garwicz, StanislawLund University,Lunds universitet,Sena effekter efter barncancerbehandling,Forskargrupper vid Lunds universitet,Late effects after childhood cancer treatment,Lund University Research Groups,Skåne University Hospital(Swepub:lu)st6750ga (författare)
- Linge, HelenaLund University,Lunds universitet,Sena effekter efter barncancerbehandling,Forskargrupper vid Lunds universitet,Late effects after childhood cancer treatment,Lund University Research Groups,Skåne University Hospital(Swepub:lu)medk-hjo (författare)
- Wiebe, ThomasLund University,Lunds universitet,Sena effekter efter barncancerbehandling,Forskargrupper vid Lunds universitet,Late effects after childhood cancer treatment,Lund University Research Groups,Skåne University Hospital(Swepub:lu)pedi-twi (författare)
- Hjorth, LarsLund University,Lunds universitet,Sena effekter efter barncancerbehandling,Forskargrupper vid Lunds universitet,Late effects after childhood cancer treatment,Lund University Research Groups,Skåne University Hospital(Swepub:lu)pedi-lhj (författare)
- Reulen, Raoul C.University of Birmingham (författare)
- University of Paris-SaclayUniversity of Birmingham (creator_code:org_t)
- et al.
Sammanhörande titlar
- Ingår i:European Journal of Cancer: Elsevier BV117, s. 71-831879-08520959-8049
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- European Journal of Cancer (Sök värdpublikationen i LIBRIS)
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