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  • Aronsson, Carin AndrénLund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups (författare)

Dietary Intake and Body Mass Index Influence the Risk of Islet Autoimmunity in Genetically At-Risk Children : A Mediation Analysis Using the TEDDY Cohort

  • Artikel/kapitelEngelska2023

Förlag, utgivningsår, omfång ...

  • Hindawi Limited,2023

Nummerbeteckningar

  • LIBRIS-ID:oai:lup.lub.lu.se:d7ba4a7c-e8da-4a9c-b698-403fb80aee1c
  • https://lup.lub.lu.se/record/d7ba4a7c-e8da-4a9c-b698-403fb80aee1cURI
  • https://doi.org/10.1155/2023/3945064DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

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Klassifikation

  • Ämneskategori:art swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype

Anmärkningar

  • Background/Objective: Growth and obesity have been associated with increased risk of islet autoimmunity (IA) and progression to type 1 diabetes. We aimed to estimate the effect of energy-yielding macronutrient intake on the development of IA through BMI. Research Design and Methods: Genetically at-risk children (n = 5,084) in Finland, Germany, Sweden, and the USA, who were autoantibody negative at 2 years of age, were followed to the age of 8 years, with anthropometric measurements and 3-day food records collected biannually. Of these, 495 (9.7%) children developed IA. Mediation analysis for time-varying covariates (BMI z-score) and exposure (energy intake) was conducted. Cox proportional hazard method was used in sensitivity analysis. Results: We found an indirect effect of total energy intake (estimates: indirect effect 0.13 [0.05, 0.21]) and energy from protein (estimates: indirect effect 0.06 [0.02, 0.11]), fat (estimates: indirect effect 0.03 [0.01, 0.05]), and carbohydrates (estimates: indirect effect 0.02 [0.00, 0.04]) (kcal/day) on the development of IA. A direct effect was found for protein, expressed both as kcal/day (estimates: direct effect 1.09 [0.35, 1.56]) and energy percentage (estimates: direct effect 72.8 [3.0, 98.0]) and the development of GAD autoantibodies (GADA). In the sensitivity analysis, energy from protein (kcal/day) was associated with increased risk for GADA, hazard ratio 1.24 (95% CI: 1.09, 1.53), p = 0.042. Conclusions: This study confirms that higher total energy intake is associated with higher BMI, which leads to higher risk of the development of IA. A diet with larger proportion of energy from protein has a direct effect on the development of GADA.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Tamura, RoyUniversity of South Florida (författare)
  • Vehik, KendraUniversity of South Florida(Swepub:lu)med-krv (författare)
  • Uusitalo, UllaUniversity of South Florida (författare)
  • Yang, JiminUniversity of South Florida (författare)
  • Haller, Michael J.University of Florida (författare)
  • Toppari, JormaTurku University Hospital,University of Turku (författare)
  • Hagopian, WilliamPacific Northwest Research Institute (författare)
  • McIndoe, Richard A.Medical College of Georgia (författare)
  • Rewers, Marian J.Barbara Davis Center for Childhood Diabetes (författare)
  • Ziegler, Anette G.Klinikum rechts der Isar (författare)
  • Akolkar, BeenaNational Institute of Diabetes and Digestive and Kidney Diseases (författare)
  • Krischer, Jeffrey P.University of South Florida (författare)
  • Norris, Jill M.University of Colorado (författare)
  • Virtanen, Suvi M.Finnish National Institute for Health and Welfare,Tampere University Hospital,University of Tampere (författare)
  • Larsson, Helena EldingLund University,Lunds universitet,Pediatrisk endokrinologi,Forskargrupper vid Lunds universitet,Paediatric Endocrinology,Lund University Research Groups,Skåne University Hospital(Swepub:lu)pedi-hla (författare)
  • Celiaki och diabetesForskargrupper vid Lunds universitet (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Pediatric Diabetes: Hindawi Limited20231399-543X1399-5448

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