SwePub
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Flachs Esben Meulengracht)
 

Sökning: WFRF:(Flachs Esben Meulengracht) > The epidemiologic e...

  • Bonde, Jens PeterBispebjerg Hospital (författare)

The epidemiologic evidence linking prenatal and postnatal exposure to endocrine disrupting chemicals with male reproductive disorders : A systematic review and meta-analysis

  • Artikel/kapitelEngelska2016

Förlag, utgivningsår, omfång ...

  • 2016
  • 22 s.

Nummerbeteckningar

  • LIBRIS-ID:oai:lup.lub.lu.se:d7c8477f-8e3c-47f1-b75f-5acea21dea4e
  • https://lup.lub.lu.se/record/d7c8477f-8e3c-47f1-b75f-5acea21dea4eURI
  • https://doi.org/10.1093/HUMUPD/DMW036DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:art swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype

Anmärkningar

  • BACKGROUND: More than 20 years ago, it was hypothesized that exposure to prenatal and early postnatal environmental xenobiotics with the potential to disrupt endogenous hormone signaling might be on the causal path to cryptorchidism, hypospadias, low sperm count and testicular cancer. Several consensus statements and narrative reviews in recent years have divided the scientific community and have elicited a call for systematic transparent reviews. We aimed to fill this gap in knowledge in the field of male reproductive disorders. OBJECTIVE AND RATIONALE: The aim of this study was to systematically synthesize published data on the risk of cryptorchidism, hypospadias, low sperm counts and testicular cancer following in utero or infant exposure to chemicals that have been included on the European Commission's list of Category 1 endocrine disrupting chemicals defined as having documented adverse effects due to endocrine disruption in at least one intact organism. SEARCH METHODS: A systematic literature search for original peer reviewed papers was performed in the databases PubMed and Embase to identify epidemiological studies reporting associations between the outcomes of interest and exposures documented by biochemical analyses of biospecimens including maternal blood or urine, placenta or fat tissue as well as amnion fluid, cord blood or breast milk; this was followed by meta-analysis of quantitative data. OUTCOMES: The literature search resulted in 1314 references among which we identified 33 papers(28 study populations) fulfilling the eligibility criteria. These provided 85 risk estimates of links between persistent organic pollutants and rapidly metabolized compounds (phthalates and Bisphenol A) and male reproductive disorders. The overall odds ratio (OR) across all exposures and outcomes was 1.11 (95% CI 0.91-1.35). When assessing four specific chemical subgroups with sufficient data for meta-analysis for all outcomes, we found that exposure to one of the four compounds, p,p'-DDE, was related to an elevated risk: OR 1.35 (95% CI 1.04-1.74). The data did not indicate that this increased risk was driven by any specific disorder. WIDER IMPLICATIONS: The current epidemiological evidence is compatible with a small increased risk of male reproductive disorders following prenatal and postnatal exposure to some persistent environmental chemicals classified as endocrine disruptors but the evidence is limited. Future epidemiological studies may change the weight of the evidence in either direction. No evidence of distortion due to publication bias was found, but exposure-response relationships are not evident. There are insufficient data on rapidly metabolized endocrine disruptors and on specific exposure-outcome relations. A particular data gap is evident with respect to delayed effects on semen quality and testicular cancer. Although high quality epidemiological studies are still sparse, future systematic and transparent reviews may provide pieces of evidence contributing to the narrative and weight of the evidence assessments in the field.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Flachs, Esben MeulengrachtBispebjerg Hospital (författare)
  • Rimborg, SusieUniversity of Copenhagen (författare)
  • Glazer, Clara HeleneBispebjerg Hospital (författare)
  • Giwercman, AleksanderLund University,Lunds universitet,Molekylärgenetisk reproduktionsmedicin, Malmö,Forskargrupper vid Lunds universitet,Reproduktionsmedicin, Malmö,Molecular genetic reproductive medicine, Malmö,Lund University Research Groups,Reproductive medicine, Malmö(Swepub:lu)kir-agi (författare)
  • Ramlau-Hansen, Cecilia HøstAarhus University (författare)
  • Hougaard, Karin SørigThe National Research Centre for the Working Environment (författare)
  • Høyer, Birgit BjerreBispebjerg Hospital,Aarhus University Hospital (författare)
  • Hærvig, Katia KeglbergBispebjerg Hospital (författare)
  • Petersen, Sesilje BondoBispebjerg Hospital (författare)
  • Rylander, LarsLund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)ymed-lry (författare)
  • Specht, Ina OlmerBispebjerg Hospital (författare)
  • Toft, GunnarAarhus University Hospital (författare)
  • Bräuner, Elvira VaclavikBispebjerg Hospital,University of Copenhagen (författare)
  • Bispebjerg HospitalUniversity of Copenhagen (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Human Reproduction Update23:1, s. 104-1251355-4786

Internetlänk

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy