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  • Specht, Ina Olmer (author)

Environmental Hexachlorobenzene exposure and human male reproductive function.

  • Article/chapterEnglish2015

Publisher, publication year, extent ...

  • Elsevier BV,2015

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:d8281c44-01f2-4bea-94c8-3ea79bd5ecd4
  • https://lup.lub.lu.se/record/7720745URI
  • https://doi.org/10.1016/j.reprotox.2015.07.074DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Hexachlorobenzene (HCB) is a persistent environmental fungicide that may disrupt androgen regulation. The aim of this study was to investigate associations between HCB levels and biomarkers of male reproductive function. 589 spouses of pregnant women from Greenland, Poland and Ukraine were enrolled between 2002 and 2004. The men provided semen and blood samples and were interviewed. HCB was measured in serum by gas chromatography. The mean serum concentrations of HCB were higher in Ukraine (182.3 ng/g lipid) and Greenland (79.0 ng/g lipid) compared to Poland (14.2 ng/g lipid). Sex Hormone Binding Globulin (SHBG) and Free Androgen Index (FAI) were associated with HCB in men from Ukraine and Poland. This study spanning large differences in environmental HCB exposure levels shows a positive association for SHBG and negative association for FAI with high serum levels of HCB in fertile men, but without major consequences for semen quality and the Inuit study population.

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  • Bonde, Jens Peter Ellekilde (author)
  • Toft, Gunnar (author)
  • Giwercman, AleksanderLund University,Lunds universitet,Reproduktionsmedicin, Malmö,Forskargrupper vid Lunds universitet,Reproductive medicine, Malmö,Lund University Research Groups(Swepub:lu)kir-agi (author)
  • Spanò, Marcello (author)
  • Bizzaro, Davide (author)
  • Manicardi, Gian Carlo (author)
  • Jönsson, Bo ALund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)ymed-bjo (author)
  • Robbins, Wendie A (author)
  • Reproduktionsmedicin, MalmöForskargrupper vid Lunds universitet (creator_code:org_t)

Related titles

  • In:Reproductive Toxicology: Elsevier BV58:Jul 22, s. 8-141873-17080890-6238

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