Spermidine/spermine-N1-acetyltransferase activity in isoprenaline-stimulated rat salivary glands

• In parotid, sublingual and submaxillary glands stimulated by continuous intravenous infusion of isoprenaline at various doses for 3 h, the concentrations of the polyamines putrescine, spermidine, spermine and N1-acetylspermidine as well as the activities of ornithine decarboxylase and spermidine/spermine-N1-acetyltransferase were determined. Ornithine decarboxylase is the enzyme that catalyses the formation of putrescine from ornithine. The most striking effect was observed in parotid glands. Here, the beta-adrenergic agonist increased the activity of spermidine/spermine-N1-acetyltransferase markedly, but only slightly (if at all) that of ornithine decarboxylase. It also increased the concentrations of N1-acetylspermidine and putrescine markedly. The result obtained in this gland indicates interconversion of higher polyamines to putrescine.

Nyckelord

Acetyltransferases

Animals

Infusions, Intravenous

Isoproterenol

Male

Organ Size

Ornithine Decarboxylase

Putrescine

Rats

Rats, Inbred Strains

Salivary Glands

Spermidine

Spermine

Publikations- och innehållstyp

art (ämneskategori)

ref (ämneskategori)