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Genetic studies of ...
Genetic studies of body mass index yield new insights for obesity biology.
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Locke, Adam E (author)
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Kahali, Bratati (author)
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Berndt, Sonja I (author)
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Justice, Anne E (author)
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- Pers, Tune H (author)
- Karolinska Institutet
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Day, Felix R (author)
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Powell, Corey (author)
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Vedantam, Sailaja (author)
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- Lind, Lars (author)
- Uppsala universitet,Kardiovaskulär epidemiologi
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Yang, Jian (author)
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Croteau-Chonka, Damien C (author)
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Esko, Tonu (author)
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- Fall, Tove (author)
- Uppsala universitet,Karolinska Institutet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab
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Ferreira, Teresa (author)
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- Gustafsson, Stefan (author)
- Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab
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Kutalik, Zoltán (author)
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Luan, Jian'an (author)
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Mägi, Reedik (author)
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Randall, Joshua C (author)
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Winkler, Thomas W (author)
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Wood, Andrew R (author)
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Workalemahu, Tsegaselassie (author)
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Faul, Jessica D (author)
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Smith, Jennifer A (author)
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Hua Zhao, Jing (author)
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Zhao, Wei (author)
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Chen, Jin (author)
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Fehrmann, Rudolf (author)
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- Hedman, Åsa K (author)
- Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab
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Karjalainen, Juha (author)
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Schmidt, Ellen M (author)
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Absher, Devin (author)
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Amin, Najaf (author)
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Anderson, Denise (author)
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Beekman, Marian (author)
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Bolton, Jennifer L (author)
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Bragg-Gresham, Jennifer L (author)
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Buyske, Steven (author)
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Demirkan, Ayse (author)
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Deng, Guohong (author)
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Ehret, Georg B (author)
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Feenstra, Bjarke (author)
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Feitosa, Mary F (author)
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Fischer, Krista (author)
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Goel, Anuj (author)
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Gong, Jian (author)
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Jackson, Anne U (author)
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Kanoni, Stavroula (author)
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Kleber, Marcus E (author)
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- Kristiansson, Kati (author)
- Karolinska Institutet
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Lim, Unhee (author)
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Lotay, Vaneet (author)
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Mangino, Massimo (author)
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Mateo Leach, Irene (author)
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Medina-Gomez, Carolina (author)
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Medland, Sarah E (author)
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Nalls, Michael A (author)
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Palmer, Cameron D (author)
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Pasko, Dorota (author)
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Pechlivanis, Sonali (author)
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Peters, Marjolein J (author)
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Prokopenko, Inga (author)
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- Shungin, Dmitry (author)
- Umeå universitet,Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genetisk och molekylär epidemiologi,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Genetic and Molecular Epidemiology,Medicin,Institutionen för odontologi
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Stančáková, Alena (author)
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- Strawbridge, Rona J (author)
- Karolinska Institutet
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Ju Sung, Yun (author)
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Tanaka, Toshiko (author)
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Teumer, Alexander (author)
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Trompet, Stella (author)
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van der Laan, Sander W (author)
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van Setten, Jessica (author)
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Van Vliet-Ostaptchouk, Jana V (author)
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Wang, Zhaoming (author)
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Yengo, Loïc (author)
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Zhang, Weihua (author)
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Isaacs, Aaron (author)
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Albrecht, Eva (author)
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- Ärnlöv, Johan (author)
- Högskolan Dalarna,Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab,Medicinsk vetenskap
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Arscott, Gillian M (author)
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Attwood, Antony P (author)
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Bandinelli, Stefania (author)
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Barrett, Amy (author)
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Bas, Isabelita N (author)
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Bellis, Claire (author)
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Bennett, Amanda J (author)
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- Berne, Christian (author)
- Uppsala universitet,Klinisk diabetologi och metabolism
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Blagieva, Roza (author)
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Blüher, Matthias (author)
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Böhringer, Stefan (author)
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Bonnycastle, Lori L (author)
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Böttcher, Yvonne (author)
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Boyd, Heather A (author)
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Bruinenberg, Marcel (author)
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Caspersen, Ida H (author)
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Ida Chen, Yii-Der (author)
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Clarke, Robert (author)
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Daw, E Warwick (author)
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de Craen, Anton J M (author)
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Delgado, Graciela (author)
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Dimitriou, Maria (author)
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Doney, Alex S F (author)
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Eklund, Niina (author)
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Estrada, Karol (author)
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Eury, Elodie (author)
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Folkersen, Lasse (author)
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Fraser, Ross M (author)
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Garcia, Melissa E (author)
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Geller, Frank (author)
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- Uppsala universitet,Geriatrik
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- Gigante, Bruna (author)
- Karolinska Institutet
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Go, Alan S (author)
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Golay, Alain (author)
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- Goodall, Alison H (author)
- Karolinska Institutet
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Gordon, Scott D (author)
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Gorski, Mathias (author)
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Grabe, Hans-Jörgen (author)
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Grallert, Harald (author)
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Grammer, Tanja B (author)
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Gräßler, Jürgen (author)
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- Grönberg, Henrik (author)
- Karolinska Institutet
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Groves, Christopher J (author)
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Gusto, Gaëlle (author)
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Haessler, Jeffrey (author)
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Hall, Per (author)
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Haller, Toomas (author)
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- Hallmans, Göran (author)
- Umeå universitet,Näringsforskning,Enheten för biobanksforskning
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Hartman, Catharina A (author)
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Hassinen, Maija (author)
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Hayward, Caroline (author)
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Heard-Costa, Nancy L (author)
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Helmer, Quinta (author)
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Hengstenberg, Christian (author)
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Holmen, Oddgeir (author)
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Hottenga, Jouke-Jan (author)
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James, Alan L (author)
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Jeff, Janina M (author)
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- Johansson, Åsa (author)
- Uppsala universitet,Medicinsk genetik och genomik,Science for Life Laboratory, SciLifeLab
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- Jolley, Jennifer (author)
- Karolinska Institutet
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Juliusdottir, Thorhildur (author)
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Kinnunen, Leena (author)
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Koenig, Wolfgang (author)
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Koskenvuo, Markku (author)
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Kratzer, Wolfgang (author)
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Laitinen, Jaana (author)
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Lamina, Claudia (author)
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Leander, Karin (author)
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Lee, Nanette R (author)
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Lichtner, Peter (author)
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- Lind, Lars (author)
- Karolinska Institutet
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Lindström, Jaana (author)
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Sin Lo, Ken (author)
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Lobbens, Stéphane (author)
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Lorbeer, Roberto (author)
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Lu, Yingchang (author)
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Mach, François (author)
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- Karolinska Institutet
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Mahajan, Anubha (author)
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McArdle, Wendy L (author)
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McLachlan, Stela (author)
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Menni, Cristina (author)
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Merger, Sigrun (author)
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Mihailov, Evelin (author)
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Milani, Lili (author)
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Moayyeri, Alireza (author)
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Monda, Keri L (author)
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Morken, Mario A (author)
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Mulas, Antonella (author)
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Müller, Gabriele (author)
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Müller-Nurasyid, Martina (author)
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Musk, Arthur W (author)
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Nagaraja, Ramaiah (author)
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Nöthen, Markus M (author)
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Nolte, Ilja M (author)
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Pilz, Stefan (author)
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Rayner, Nigel W (author)
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- Renström, Frida (author)
- Umeå universitet,Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Näringsforskning,Enheten för biobanksforskning
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Rettig, Rainer (author)
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Ried, Janina S (author)
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Ripke, Stephan (author)
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Robertson, Neil R (author)
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Rose, Lynda M (author)
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Sanna, Serena (author)
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Scharnagl, Hubert (author)
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Scholtens, Salome (author)
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Schumacher, Fredrick R (author)
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Scott, William R (author)
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Seufferlein, Thomas (author)
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Shi, Jianxin (author)
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Vernon Smith, Albert (author)
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Smolonska, Joanna (author)
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Stanton, Alice V (author)
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Steinthorsdottir, Valgerdur (author)
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Stirrups, Kathleen (author)
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Stringham, Heather M (author)
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- Sundström, Johan (author)
- Uppsala universitet,Kardiovaskulär epidemiologi
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Swertz, Morris A (author)
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Swift, Amy J (author)
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- Syvänen, Ann-Christine (author)
- Uppsala universitet,Molekylär medicin,Science for Life Laboratory, SciLifeLab
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Tan, Sian-Tsung (author)
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Tayo, Bamidele O (author)
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Thorand, Barbara (author)
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Thorleifsson, Gudmar (author)
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Tyrer, Jonathan P (author)
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Uh, Hae-Won (author)
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- Vandenput, Liesbeth, 1974 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
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Verhulst, Frank C (author)
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Vermeulen, Sita H (author)
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Verweij, Niek (author)
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Vonk, Judith M (author)
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Waite, Lindsay L (author)
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Warren, Helen R (author)
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Waterworth, Dawn (author)
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Weedon, Michael N (author)
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Wilkens, Lynne R (author)
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Willenborg, Christina (author)
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Wilsgaard, Tom (author)
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Wojczynski, Mary K (author)
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Wong, Andrew (author)
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Choi, Murim (author)
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Dastani, Zari (author)
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Drong, Alexander W (author)
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Eriksson, Per (author)
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- Franco-Cereceda, Anders (author)
- Karolinska Institutet
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Gådin, Jesper R (author)
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Goddard, Michael E (author)
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Handsaker, Robert E (author)
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Huang, Jinyan (author)
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Keildson, Sarah (author)
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Kiryluk, Krzysztof (author)
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Kubo, Michiaki (author)
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McCarroll, Steven A (author)
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McKnight, Amy J (author)
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Moffatt, Miriam F (author)
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Montgomery, Grant W (author)
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Murabito, Joanne M (author)
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Nicholson, George (author)
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Nyholt, Dale R (author)
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Okada, Yukinori (author)
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Perry, John R B (author)
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Dorajoo, Rajkumar (author)
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Vinkhuyzen, Anna A E (author)
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Westra, Harm-Jan (author)
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Zheng, Wei (author)
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Zondervan, Krina T (author)
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Danesh, John (author)
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- Karolinska Institutet
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den Ruijter, Hester M (author)
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Dominiczak, Anna F (author)
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Erbel, Raimund (author)
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Erdmann, Jeanette (author)
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Gudnason, Vilmundur (author)
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- Uppsala universitet,Medicinsk genetik och genomik,Science for Life Laboratory, SciLifeLab
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Hall, Alistair S (author)
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Harris, Tamara B (author)
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Jukema, J Wouter (author)
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Kaprio, Jaakko (author)
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Kastelein, John J P (author)
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Keinanen-Kiukaanniemi, Sirkka M (author)
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Kiemeney, Lambertus A (author)
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Kumari, Meena (author)
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Kuusisto, Johanna (author)
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Lakka, Timo A (author)
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Langenberg, Claudia (author)
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Le Marchand, Loic (author)
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Lehtimäki, Terho (author)
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- Lyssenko, Valeriya (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
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Männistö, Satu (author)
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Marette, André (author)
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Matise, Tara C (author)
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McKenzie, Colin A (author)
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Moll, Frans L (author)
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Morris, Andrew D (author)
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Morris, Andrew P (author)
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Murray, Jeffrey C (author)
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Nelis, Mari (author)
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- Ohlsson, Claes, 1965 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
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Oldehinkel, Albertine J (author)
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Ong, Ken K (author)
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Madden, Pamela A F (author)
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Pasterkamp, Gerard (author)
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Peden, John F (author)
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Peters, Annette (author)
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Postma, Dirkje S (author)
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Pramstaller, Peter P (author)
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Price, Jackie F (author)
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Qi, Lu (author)
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Raitakari, Olli T (author)
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Rankinen, Tuomo (author)
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Rao, D C (author)
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Rice, Treva K (author)
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Ridker, Paul M (author)
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Rioux, John D (author)
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Ritchie, Marylyn D (author)
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Rudan, Igor (author)
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Salomaa, Veikko (author)
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Samani, Nilesh J (author)
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Saramies, Jouko (author)
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Sarzynski, Mark A (author)
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Schunkert, Heribert (author)
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Sever, Peter (author)
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Stolk, Ronald P (author)
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Strauch, Konstantin (author)
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Tönjes, Anke (author)
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Trégouët, David-Alexandre (author)
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Tremblay, Angelo (author)
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Tremoli, Elena (author)
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Virtamo, Jarmo (author)
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Vohl, Marie-Claude (author)
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Völker, Uwe (author)
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Waeber, Gérard (author)
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Willemsen, Gonneke (author)
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Witteman, Jacqueline C (author)
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Zillikens, M Carola (author)
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Adair, Linda S (author)
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Amouyel, Philippe (author)
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Asselbergs, Folkert W (author)
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Assimes, Themistocles L (author)
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Bochud, Murielle (author)
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Boehm, Bernhard O (author)
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Boerwinkle, Eric (author)
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Bornstein, Stefan R (author)
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Bottinger, Erwin P (author)
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Bouchard, Claude (author)
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Chambers, John C (author)
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Chanock, Stephen J (author)
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Cooper, Richard S (author)
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de Bakker, Paul I W (author)
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Dedoussis, George (author)
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Ferrucci, Luigi (author)
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- Franks, Paul (author)
- Umeå universitet,Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genetisk och molekylär epidemiologi,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Genetic and Molecular Epidemiology,Medicin
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Froguel, Philippe (author)
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- Groop, Leif (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
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Haiman, Christopher A (author)
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Hamsten, Anders (author)
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Hui, Jennie (author)
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Hunter, David J (author)
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Hveem, Kristian (author)
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Kaplan, Robert C (author)
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Kivimaki, Mika (author)
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Kuh, Diana (author)
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Laakso, Markku (author)
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Liu, Yongmei (author)
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Martin, Nicholas G (author)
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März, Winfried (author)
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Melbye, Mads (author)
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Metspalu, Andres (author)
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Moebus, Susanne (author)
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Munroe, Patricia B (author)
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Njølstad, Inger (author)
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Oostra, Ben A (author)
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Palmer, Colin N A (author)
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Pedersen, Nancy L (author)
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Perola, Markus (author)
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Pérusse, Louis (author)
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Peters, Ulrike (author)
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Power, Chris (author)
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Quertermous, Thomas (author)
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Rauramaa, Rainer (author)
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Rivadeneira, Fernando (author)
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Saaristo, Timo E (author)
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Saleheen, Danish (author)
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Sattar, Naveed (author)
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Schadt, Eric E (author)
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Schlessinger, David (author)
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Slagboom, P Eline (author)
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Snieder, Harold (author)
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Spector, Tim D (author)
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Thorsteinsdottir, Unnur (author)
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Stumvoll, Michael (author)
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Tuomilehto, Jaakko (author)
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Uitterlinden, André G (author)
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Uusitupa, Matti (author)
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van der Harst, Pim (author)
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Walker, Mark (author)
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Wallaschofski, Henri (author)
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Wareham, Nicholas J (author)
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Watkins, Hugh (author)
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Weir, David R (author)
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Wichmann, H-Erich (author)
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Wilson, James F (author)
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Zanen, Pieter (author)
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Borecki, Ingrid B (author)
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Deloukas, Panos (author)
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Fox, Caroline S (author)
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Heid, Iris M (author)
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O'Connell, Jeffrey R (author)
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Strachan, David P (author)
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Stefansson, Kari (author)
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van Duijn, Cornelia M (author)
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Abecasis, Gonçalo R (author)
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Franke, Lude (author)
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Frayling, Timothy M (author)
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McCarthy, Mark I (author)
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Visscher, Peter M (author)
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Scherag, André (author)
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Willer, Cristen J (author)
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Boehnke, Michael (author)
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Mohlke, Karen L (author)
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Lindgren, Cecilia M (author)
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Beckmann, Jacques S (author)
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Barroso, Inês (author)
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North, Kari E (author)
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- Ingelsson, Erik (author)
- Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab
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Hirschhorn, Joel N (author)
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Loos, Ruth J F (author)
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Speliotes, Elizabeth K (author)
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Graessler, Jurgen (author)
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(creator_code:org_t)
- 2015-02-11
- 2015
- English.
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In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 518:7538, s. 197-401
- Related links:
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- Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 × 10(-8)), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for ∼2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Keyword
- Polymorphism
- Obesity: metabolism
- Obesity: genetics
- Insulin: secretion
- Insulin: metabolism
- Glutamic Acid: metabolism
- Genetic Predisposition to Disease: genetics
- Europe: ethnology
- Energy Metabolism: genetics
- Continental Population Groups: genetics
- Adipogenesis: genetics
- Adiposity: genetics
- Single Nucleotide: genetics
- Quantitative Trait Loci: genetics
- Synapses: metabolism
- body mass; copy number variation; disease course; energy metabolism; gene expression; gene frequency; gene linkage disequilibrium; genetic association; genetic variability; heredity; human; insulin release; nonhuman; obesity; phenotype; priority journal; quantitative trait locus; receiver operating characteristic
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Locke, Adam E
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Kahali, Bratati
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Berndt, Sonja I
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Justice, Anne E
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Pers, Tune H
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Day, Felix R
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Powell, Corey
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Lind, Lars
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Yang, Jian
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Esko, Tonu
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Fall, Tove
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Ferreira, Teresa
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Gustafsson, Stef ...
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Kutalik, Zoltán
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Luan, Jian'an
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Mägi, Reedik
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Randall, Joshua ...
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Winkler, Thomas ...
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Wood, Andrew R
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Workalemahu, Tse ...
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Faul, Jessica D
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Smith, Jennifer ...
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Hua Zhao, Jing
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Zhao, Wei
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Chen, Jin
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Fehrmann, Rudolf
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Hedman, Åsa K
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Karjalainen, Juh ...
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Schmidt, Ellen M
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Absher, Devin
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Buyske, Steven
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Demirkan, Ayse
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Deng, Guohong
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Ehret, Georg B
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Feenstra, Bjarke
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Feitosa, Mary F
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Fischer, Krista
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Goel, Anuj
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Gong, Jian
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Jackson, Anne U
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Kleber, Marcus E
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Lim, Unhee
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Lotay, Vaneet
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Mangino, Massimo
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Medland, Sarah E
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Peters, Marjolei ...
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Prokopenko, Inga
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Shungin, Dmitry
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Stančáková, Alen ...
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Ju Sung, Yun
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Tanaka, Toshiko
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Teumer, Alexande ...
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van Setten, Jess ...
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Wang, Zhaoming
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Yengo, Loïc
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Zhang, Weihua
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Isaacs, Aaron
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Albrecht, Eva
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Barrett, Amy
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Bas, Isabelita N
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Berne, Christian
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Blagieva, Roza
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Böttcher, Yvonne
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Boyd, Heather A
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Caspersen, Ida H
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Clarke, Robert
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Daw, E Warwick
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Dimitriou, Maria
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Doney, Alex S F
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Eklund, Niina
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Estrada, Karol
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Eury, Elodie
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Nature
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Lund University
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Umeå University
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Karolinska Institutet
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Uppsala University
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University of Gothenburg
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Högskolan Dalarna