Search: (WFRF:(Shuldiner Alan R.)) srt2:(2015-2019) srt2:(2015) pers:(Van Duijn Cornelia M.) pers:(Lind Lars) pers:(Magnusson Patrik K E) >
Genetic studies of ...
Genetic studies of body mass index yield new insights for obesity biology.
- Article/chapterEnglish2015
Publisher, publication year, extent ...
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2015-02-11
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Springer Science and Business Media LLC,2015
Numbers
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LIBRIS-ID:oai:lup.lub.lu.se:d86b0162-3e09-4c95-b2a6-dc3f755cdec8
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https://lup.lub.lu.se/record/5143923URI
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https://doi.org/10.1038/nature14177DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-100949URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:130690386URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-244272URI
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https://gup.ub.gu.se/publication/213541URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:du-21320URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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De fem sista författarna delar sistaförfattarskapet.
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Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 × 10(-8)), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for ∼2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.
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Kahali, Bratati
(author)
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Berndt, Sonja I
(author)
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Justice, Anne E
(author)
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Pers, Tune HKarolinska Institutet
(author)
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Day, Felix R
(author)
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Powell, Corey
(author)
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Vedantam, Sailaja
(author)
-
Lind, LarsUppsala universitet,Kardiovaskulär epidemiologi(Swepub:uu)larslind
(author)
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Yang, Jian
(author)
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Croteau-Chonka, Damien C
(author)
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Esko, Tonu
(author)
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Fall, ToveUppsala universitet,Karolinska Institutet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)tovfa878
(author)
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Ferreira, Teresa
(author)
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Gustafsson, StefanUppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)stegu732
(author)
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Kutalik, Zoltán
(author)
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Luan, Jian'an
(author)
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Mägi, Reedik
(author)
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Randall, Joshua C
(author)
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Winkler, Thomas W
(author)
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Wood, Andrew R
(author)
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Workalemahu, Tsegaselassie
(author)
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Faul, Jessica D
(author)
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Smith, Jennifer A
(author)
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Hua Zhao, Jing
(author)
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Zhao, Wei
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Chen, Jin
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Fehrmann, Rudolf
(author)
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Hedman, Åsa KUppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)ashed124
(author)
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Karjalainen, Juha
(author)
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Schmidt, Ellen M
(author)
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Absher, Devin
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Amin, Najaf
(author)
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Anderson, Denise
(author)
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Beekman, Marian
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Bolton, Jennifer L
(author)
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Bragg-Gresham, Jennifer L
(author)
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Buyske, Steven
(author)
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Demirkan, Ayse
(author)
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Deng, Guohong
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Ehret, Georg B
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Feenstra, Bjarke
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Feitosa, Mary F
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Fischer, Krista
(author)
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Goel, Anuj
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Gong, Jian
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Jackson, Anne U
(author)
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Kanoni, Stavroula
(author)
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Kleber, Marcus E
(author)
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Kristiansson, KatiKarolinska Institutet
(author)
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Lim, Unhee
(author)
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Lotay, Vaneet
(author)
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Mangino, Massimo
(author)
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Mateo Leach, Irene
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Medina-Gomez, Carolina
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Medland, Sarah E
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Nalls, Michael A
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Palmer, Cameron D
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Pasko, Dorota
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Pechlivanis, Sonali
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Peters, Marjolein J
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Prokopenko, Inga
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Shungin, DmitryUmeå universitet,Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genetisk och molekylär epidemiologi,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Genetic and Molecular Epidemiology,Medicin,Institutionen för odontologi(Swepub:umu)dmsh0003
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Stančáková, Alena
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Strawbridge, Rona JKarolinska Institutet
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Ju Sung, Yun
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Tanaka, Toshiko
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Teumer, Alexander
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Trompet, Stella
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van der Laan, Sander W
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van Setten, Jessica
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Van Vliet-Ostaptchouk, Jana V
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Wang, Zhaoming
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Yengo, Loïc
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Zhang, Weihua
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Isaacs, Aaron
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Albrecht, Eva
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Ärnlöv, JohanHögskolan Dalarna,Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab,Medicinsk vetenskap(Swepub:du)jan
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Arscott, Gillian M
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Attwood, Antony P
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Bandinelli, Stefania
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Barrett, Amy
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Bas, Isabelita N
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Bellis, Claire
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Bennett, Amanda J
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Berne, ChristianUppsala universitet,Klinisk diabetologi och metabolism(Swepub:uu)chber255
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Blagieva, Roza
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Blüher, Matthias
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Böhringer, Stefan
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Bonnycastle, Lori L
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Böttcher, Yvonne
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Boyd, Heather A
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Bruinenberg, Marcel
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Ida Chen, Yii-Der
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Clarke, Robert
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Delgado, Graciela
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Fraser, Ross M
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Garcia, Melissa E
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Geller, Frank
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Giedraitis, VilmantasUppsala universitet,Geriatrik(Swepub:uu)vigie517
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Gigante, BrunaKarolinska Institutet
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Go, Alan S
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Golay, Alain
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Goodall, Alison HKarolinska Institutet
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Gordon, Scott D
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Gorski, Mathias
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Grabe, Hans-Jörgen
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Grallert, Harald
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Grammer, Tanja B
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Gräßler, Jürgen
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Grönberg, HenrikKarolinska Institutet
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Groves, Christopher J
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Gusto, Gaëlle
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Haessler, Jeffrey
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Hall, Per
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Haller, Toomas
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Hallmans, GöranUmeå universitet,Näringsforskning,Enheten för biobanksforskning(Swepub:umu)goha0001
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Hartman, Catharina A
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Hassinen, Maija
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Hayward, Caroline
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Hengstenberg, Christian
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Holmen, Oddgeir
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Hottenga, Jouke-Jan
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James, Alan L
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Jeff, Janina M
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Johansson, ÅsaUppsala universitet,Medicinsk genetik och genomik,Science for Life Laboratory, SciLifeLab(Swepub:uu)asjoh108
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Jolley, JenniferKarolinska Institutet
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Juliusdottir, Thorhildur
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Kinnunen, Leena
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Koenig, Wolfgang
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Koskenvuo, Markku
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Kratzer, Wolfgang
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Laitinen, Jaana
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Lamina, Claudia
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Leander, Karin
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Lee, Nanette R
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Lichtner, Peter
(author)
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Lind, LarsKarolinska Institutet
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Lindström, Jaana
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Sin Lo, Ken
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Lobbens, Stéphane
(author)
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Lorbeer, Roberto
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Lu, Yingchang
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Mach, François
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Magnusson, Patrik K EKarolinska Institutet
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Mahajan, Anubha
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McArdle, Wendy L
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McLachlan, Stela
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Menni, Cristina
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Nolte, Ilja M
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Pilz, Stefan
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Rayner, Nigel W
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Renström, FridaUmeå universitet,Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Näringsforskning,Enheten för biobanksforskning(Swepub:lu)med-frm
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Rettig, Rainer
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Ried, Janina S
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Sundström, JohanUppsala universitet,Kardiovaskulär epidemiologi(Swepub:uu)johasund
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Swertz, Morris A
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Syvänen, Ann-ChristineUppsala universitet,Molekylär medicin,Science for Life Laboratory, SciLifeLab(Swepub:uu)anncsyva
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Tan, Sian-Tsung
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Vandenput, Liesbeth,1974Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition(Swepub:gu)xvanli
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Eriksson, Per
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Franco-Cereceda, AndersKarolinska Institutet
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Gharavi, Ali G
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Goddard, Michael E
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Handsaker, Robert E
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Kathiresan, Sekar
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Keildson, Sarah
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Kiryluk, Krzysztof
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Kubo, Michiaki
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Lee, Jong-Young
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Liang, Liming
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Lifton, Richard P
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McCarroll, Steven A
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McKnight, Amy J
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Min, Josine L
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Moffatt, Miriam F
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Montgomery, Grant W
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Murabito, Joanne M
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Nicholson, George
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Okada, Yukinori
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Lyssenko, ValeriyaLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)endo-vly
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Sinisalo, Juha
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Stolk, Ronald P
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Strauch, Konstantin
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Tönjes, Anke
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Trégouët, David-Alexandre
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Tremblay, Angelo
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Tremoli, Elena
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Virtamo, Jarmo
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Vohl, Marie-Claude
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Völker, Uwe
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Waeber, Gérard
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Willemsen, Gonneke
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Witteman, Jacqueline C
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Zillikens, M Carola
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Adair, Linda S
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Amouyel, Philippe
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Assimes, Themistocles L
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Bochud, Murielle
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Boehm, Bernhard O
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Boerwinkle, Eric
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Bottinger, Erwin P
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Cauchi, Stéphane
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Cooper, Richard S
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de Bakker, Paul I W
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Dedoussis, George
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Ferrucci, Luigi
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Franks, PaulUmeå universitet,Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genetisk och molekylär epidemiologi,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Genetic and Molecular Epidemiology,Medicin(Swepub:umu)pafr0003
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Froguel, Philippe
(author)
-
Groop, LeifLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)endo-lgr
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Haiman, Christopher A
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Ingelsson, ErikUppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)ering425
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Graessler, Jurgen
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Karolinska InstitutetKardiovaskulär epidemiologi
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