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Plasma Protein Prof...
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Lind, LarsUppsala University,Uppsala universitet,Klinisk epidemiologi,Uppsala Univ, Sweden
(författare)
Plasma Protein Profile of Carotid Artery Atherosclerosis and Atherosclerotic Outcomes : Meta-Analyses and Mendelian Randomization Analyses
- Artikel/kapitelEngelska2021
Förlag, utgivningsår, omfång ...
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Lippincott Williams & Wilkins,2021
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-443081
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-443081URI
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https://doi.org/10.1161/ATVBAHA.120.315597DOI
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https://lup.lub.lu.se/record/0b1c8a9f-dc67-49cc-b0ca-c2baa7b2b177URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:146525143URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-175685URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:du-36863URI
Kompletterande språkuppgifter
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Språk:engelska
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Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Funding Agencies|Uppsala University Hospital; Swedish Heart and Lung foundationSwedish Heart-Lung Foundation; Swedish research councilSwedish Research CouncilEuropean Commission; Stockholm County Council (ALF)Stockholm County Council; EU grantEuropean Commission
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OBJECTIVE: To identify causal pathophysiological mechanisms for atherosclerosis and incident cardiovascular events using protein measurements.APPROACH AND RESULTS: Carotid artery atherosclerosis was assessed by ultrasound, and 86 cardiovascular-related proteins were measured using the Olink CVD-I panel in 7 Swedish prospective studies (11 754 individuals). The proteins were analyzed in relation to intima-media thickness in the common carotid artery (IMT-CCA), plaque occurrence, and incident cardiovascular events (composite end point of myocardial infarction or ischemic stroke) using a discovery/replication approach in different studies. After adjustments for traditional cardiovascular risk factors, 11 proteins remained significantly associated with IMT-CCA in the replication stage, whereas 9 proteins were replicated for plaque occurrence and 17 proteins for incident cardiovascular events. NT-proBNP (N-terminal pro-B-type natriuretic peptide) and MMP (matrix metalloproteinase)-12 were associated with both IMT-CCA and incident events, but the overlap was considerably larger between plaque occurrence and incident events, including MMP-12, TIM-1 (T-cell immunoglobulin and mucin domain 1), GDF (growth/differentiation factor)-15, IL (interleukin)-6, U-PAR (urokinase plasminogen activator surface receptor), LOX-1 (lectin-like oxidized LDL [low-density lipoprotein] receptor 1), and TRAIL-R2 (TNF [tumor necrosis factor]-related apoptosis-inducing ligand receptor 2). Only MMP-12 was associated with IMT-CCA, plaque, and incident events with a positive and concordant direction of effect. However, a 2-sample Mendelian randomization analysis suggested that increased MMP-12 may be protective against ischemic stroke (P=5.5x10(-7)), which is in the opposite direction of the observational analyses.CONCLUSIONS: The present meta-analysis discovered several proteins related to carotid atherosclerosis that partly differed in their association with IMT-CCA, plaque, and incident atherosclerotic disease. Mendelian randomization analysis for the top finding, MMP-12, suggests that the increased levels of MMP-12 could be a consequence of atherosclerotic burden rather than the opposite chain of events.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Gigante, BrunaKarolinska Institutet,Karolinska Institute,Karolinska Inst, Dept Med, Unit Cardiovasc Med, Stockholm, Sweden.
(författare)
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Borné, YanLund University,Lunds universitet,Nutritionsepidemiologi,Forskargrupper vid Lunds universitet,Nutrition Epidemiology,Lund University Research Groups,Lund Univ, Dept Clin Sci Malmö, Lund, Sweden.(Swepub:lu)med-boy
(författare)
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Rudholm Feldreich, TobiasHögskolan Dalarna,Dalarna University College,Dalarna Univ, Sch Hlth & Social Sci, Falun, Sweden.,Medicinsk vetenskap(Swepub:du)trf
(författare)
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Leppert, JerzyUppsala University,Uppsala universitet,Centrum för klinisk forskning, Västerås,Uppsala Univ, Sweden(Swepub:uu)jelep103
(författare)
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Hedberg, PärUppsala universitet,Centrum för klinisk forskning, Västerås,Vastmanland Cty Hosp, Dept Clin Physiol, Västerås, Sweden.,Västmanland Hospital,Uppsala Univ, Sweden; Vastmanland Cty Hosp, Sweden(Swepub:uu)parhe939
(författare)
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Östgren, Carl JohanLinköpings universitet,Linköping University,Avdelningen för prevention, rehabilitering och nära vård,Medicinska fakulteten,Region Östergötland, Vårdcentralen Ekholmen,Department of Medicine, Boston University, MA, USA,Linköping Univ, Dept Hlth Med & Caring Sci, Linköping, Sweden.(Swepub:liu)caros18
(författare)
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Nyström, Fredrik HLinköpings universitet,Linköping University,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Vårdcentralen Cityhälsan Centrum,Linköping Univ, Dept Hlth Med & Caring Sci, Linköping, Sweden.(Swepub:liu)freny92
(författare)
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Sundström, Johan,Professor,1971-Uppsala universitet,Klinisk epidemiologi,Univ New South Wales, George Inst Global Hlth, Sydney, NSW, Australia.,University of New South Wales,Uppsala Univ, Sweden; Univ New South Wales, Australia(Swepub:uu)johasund
(författare)
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Ärnlöv, Johan,1970-Högskolan Dalarna,Karolinska Institutet,Dalarna University College,Dalarna Univ, Sch Hlth & Social Sci, Falun, Sweden.,Medicinsk vetenskap(Swepub:du)jan
(författare)
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Baldassarre, DamianoUniv Milan, Dept Med Biotechnol & Translat Med, Damiano Baldassarre, Milan, Italy.;IRCCS, Ctr Cardiol Monzino, Milan, Italy.,University of Milan
(författare)
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Tremoli, ElenaIRCCS, Ctr Cardiol Monzino, Milan, Italy.
(författare)
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Veglia, FabrizioIRCCS, Ctr Cardiol Monzino, Milan, Italy.
(författare)
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Hamsten, AndersKarolinska Institutet,Karolinska Inst, Dept Med, Unit Cardiovasc Med, Stockholm, Sweden.;Karolinska Inst, Div Family Med & Primary Care, Dept Neurobiol Care Sci & Soc, Huddinge, Sweden.
(författare)
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O'Donnell, Christopher J.Boston Univ, Dept Med, Boston, MA USA.,Boston University
(författare)
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Franceschini, NoraUniv North Caroline, Dept Epidemiol, Capel Hill, NC USA.,University of North Carolina
(författare)
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Orho-Melander, MarjuLund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups,Lund Univ, Dept Clin Sci Malmö, Lund, Sweden.(Swepub:lu)endo-mor
(författare)
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Nilsson, JanLund University,Lunds universitet,Kirurgi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lever-, pankreas- och gallvägskirurgi,Forskargrupper vid Lunds universitet,Surgery (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Hepato-Pancreato-Biliary Surgery,Lund University Research Groups,Lund Univ, Dept Clin Sci Malmö, Lund, Sweden.(Swepub:lu)med-jn6
(författare)
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Melander, OlleLund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups,Lund Univ, Dept Clin Sci Malmö, Lund, Sweden.(Swepub:lu)endo-ome
(författare)
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Engström, GunnarLund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups,Lund Univ, Dept Clin Sci Malmö, Lund, Sweden.(Swepub:lu)smi-gen
(författare)
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Mälarstig, AndersKarolinska Institutet,Karolinska Institute,Karolinska Inst, Dept Med, Unit Cardiovasc Med, Stockholm, Sweden.
(författare)
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Uppsala universitetKlinisk epidemiologi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Arteriosclerosis, Thrombosis and Vascular Biology: Lippincott Williams & Wilkins41:5, s. 1777-17881079-56421524-4636
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Till lärosätets databas
- Av författaren/redakt...
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Lind, Lars
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Gigante, Bruna
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Borné, Yan
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Rudholm Feldreic ...
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Leppert, Jerzy
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Hedberg, Pär
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visa fler...
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Östgren, Carl Jo ...
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Nyström, Fredrik ...
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Sundström, Johan ...
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Ärnlöv, Johan, 1 ...
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Baldassarre, Dam ...
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Tremoli, Elena
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Veglia, Fabrizio
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Hamsten, Anders
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O'Donnell, Chris ...
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Franceschini, No ...
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Orho-Melander, M ...
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Nilsson, Jan
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Melander, Olle
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Engström, Gunnar
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Mälarstig, Ander ...
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visa färre...
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och Klinisk medicin
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och Kardiologi
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Arteriosclerosis ...
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Uppsala universitet
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Karolinska Institutet
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Linköpings universitet
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Högskolan Dalarna