Sökning: (hsv:(MEDICAL AND HEALTH SCIENCES) hsv:(Clinical Medicine) hsv:(Dermatology and Venereal Diseases)) srt2:(2000-2004)
> (2003) >
Reactivity of conta...
-
Ahlfors, StefanLund University,Lunds universitet,Dermatologi och venereologi, Lund,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Dermatology and Venereology (Lund),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine
(författare)
Reactivity of contact allergenic haptens to amino acid residues in a model carrier peptide, and characterisation of formed peptide-hapten adducts
- Artikel/kapitelEngelska2003
Förlag, utgivningsår, omfång ...
-
2003-02-05
-
S. Karger AG,2003
Nummerbeteckningar
-
LIBRIS-ID:oai:lup.lub.lu.se:d8f12877-a5ff-4fbf-9fd9-858d57e0aec7
-
https://lup.lub.lu.se/record/127879URI
-
https://doi.org/10.1159/000068288DOI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:art swepub-publicationtype
-
Ämneskategori:ref swepub-contenttype
Anmärkningar
-
The type of chemical reaction between hapten and carrier protein in the formation of a complete antigen in vivo giving rise to an allergic contact dermatitis (ACD, type IV allergy) is essentially unknown. About 4,000 low-molecular organic compounds are known to have allergenic properties. ,-Unsaturated carbonyl structures are frequently present among these compounds. Haptens giving rise to antibody formation and type I allergy have been shown to add predominantly to lysine in the carrier protein. In this paper, the reactivity of activated type IV haptens to a model peptide is reported. Essentially all amino acids with nucleophilic properties were present in the model peptide. Investigation of the relative reactivities of the amino acid residues to activated haptens under biomimetic conditions is performed in order to determine the proportions between the adducts of the different amino acid moieties. In all cases, the electrophilic ,-unsaturated haptens were found to be added to the cysteine residue and no lysine adduct was recorded. Nuclear magnetic resonance (NMR) spectroscopy was used to exclude steric hindrance of any amino acid residue in the addition reaction. The hapten-modified peptides were isolated and characterized by NMR and mass spectrometry.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Sterner, OlovLund University,Lunds universitet,Centrum för analys och syntes,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Centre for Analysis and Synthesis,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH(Swepub:lu)ok2-ost
(författare)
-
Hansson, ChristianLund University,Lunds universitet,Centrum för analys och syntes,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Centre for Analysis and Synthesis,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH(Swepub:lu)inor-cha
(författare)
-
Dermatologi och venereologi, LundSektion III
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:Skin Pharmacology and Applied Skin Physiology: S. Karger AG16:1, s. 59-681422-2868
-
Ingår i:Skin Pharmacology and Physiology: S. Karger AG16:1, s. 59-681660-55271660-5535
Internetlänk
Hitta via bibliotek
Till lärosätets databas