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Bladder volume alte...
Bladder volume alters cholinergic responses of the isolated whole mouse bladder
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Lagou, M (författare)
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Gillespie, JI (författare)
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- Andersson, Karl-Erik (författare)
- Lund University,Lunds universitet,Avdelningen för klinisk kemi och farmakologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Chemistry and Pharmacology,Department of Laboratory Medicine,Faculty of Medicine
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Kirkwood, T (författare)
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Drake, MJ (författare)
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(creator_code:org_t)
- 2006
- 2006
- Engelska.
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Ingår i: Journal of Urology. - 1527-3792. ; 175:2, s. 771-776
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Purpose: The isolated bladder expresses autonomous activity, which may contribute to the generation of lower urinary tract sensation or pathophysiology. We evaluated how the effect of a cholinergic agonist on autonomous activity alters with increasing volume and in the presence of substances known to modulate functional bladder capacity. Materials and Methods: The bladder of 22 adult female C57 black mice were mounted in whole organ tissue baths. Recordings of intravesical pressure were performed under standardized conditions at different bladder volumes. Results: At low volume the muscarinic agonist arecaidine elicited an initial peak response, which subsided to a sustained steady state pressure. At high volume phasic pressure fluctuations were also apparent. An M-2-receptor antagonist caused a significantly greater decrease in peak and steady state responses than in pressure fluctuations. An M-3-receptor antagonist decreased all 3 components. alpha, beta-methylene adenosine triphosphate markedly decreased fluctuations, in contrast to norepinephrine, which eliminated the steady state response while preserving fluctuations. Conclusions: The response to cholinergic stimulation of the isolated bladder has 3 components. The initial tonic peak response increases with bladder distention and it is inhibited by M-2 and M-3 muscarinic receptor antagonists. The tonic steady state response does not vary with bladder volume and it is inhibited by M-2 and M-3-receptor antagonists, and by beta(3)-adrenergic receptor agonists. Phasic fluctuations are minimal at low bladder volume, and with alpha, beta-methylene adenosine triphosphate or an M3-receptor antagonist. Thus, the response to cholinergic stimulation varies with bladder volume. It can be differentially modulated by muscarinic antagonists and also by agents acting through nonmuscarinic receptors.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Nyckelord
- muscle
- smooth
- mice
- bladder
- urinary incontinence
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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