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Remission and low d...
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Barber, Megan R.W.Cumming School of Medicine
(författare)
Remission and low disease activity are associated with lower healthcare costs : results from the Systemic Lupus International Collaborating Clinics (SLICC) inception cohort
- Artikel/kapitelEngelska2024
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Nummerbeteckningar
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LIBRIS-ID:oai:lup.lub.lu.se:d903e1cb-1655-4f7b-a6c8-91fd6c2ad656
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https://lup.lub.lu.se/record/d903e1cb-1655-4f7b-a6c8-91fd6c2ad656URI
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https://doi.org/10.1136/ard-2024-225613DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
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Objectives: This study aims to determine the independent impact of definitions of remission/low disease activity (LDA) on direct/indirect costs (DCs, ICs) in a multicentre inception cohort. Methods: Patients from 31 centres in 10 countries were enrolled within 15 months of diagnosis and assessed annually. Five mutually exclusive disease activity states (DAS) were defined as (1) remission off-treatment: clinical (c) SLEDAI-2K=0, without prednisone/immunosuppressants; (2) remission on-treatment: cSLEDAI-2K=0, prednisone ≤5 mg/day and/or maintenance immunosuppressants; (3) LDA-Toronto Cohort (TC): cSLEDAI-2K≤2, without prednisone/immunosuppressants; (4) modified lupus LDA state (mLLDAS): SLEDAI-2K≤4, no activity in major organs/systems, no new activity, prednisone ≤7.5 mg/day and/or maintenance immunosuppressants and (5) active: all remaining assessments. At each assessment, patients were stratified into the most stringent DAS fulfilled and the proportion of time in a DAS since cohort entry was determined. Annual DCs/ICs (2021 Canadian dollars) were based on healthcare use and lost workforce/non-workforce productivity over the preceding year. The association between the proportion of time in a DAS and annual DC/IC was examined through multivariable random-effects linear regressions. Results: 1692 patients were followed a mean of 9.7 years; 49.0% of assessments were active. Remission/LDA (per 25% increase in time in a remission/LDA state vs active) were associated with lower annual DC/IC: remission off-treatment (DC -$C1372; IC -$C2507), remission on-treatment (DC -$C973; IC -$C2604,) LDA-TC (DC -$C1158) and mLLDAS (DC -$C1040). There were no cost differences between remission/LDA states. Conclusions: Our data suggest that systemic lupus erythematosus patients who achieve remission, both off and on-therapy, and reductions in disease activity incur lower costs than those experiencing persistent disease activity.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Ugarte-Gil, Manuel FranciscoHospital Nacional Guillermo Almenara Irigoyen, EsSalud,Scientific University of the South, Lima
(författare)
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Hanly, John G.Dalhousie University
(författare)
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Urowitz, Murray B.Toronto Western Hospital
(författare)
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St-Pierre, YvanMcGill University Health Center
(författare)
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Gordon, Caroline
(författare)
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Bae, Sang CheolHanyang University Hospital for Rheumatic Disease
(författare)
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Romero-Diaz, JuanitaSalvador Zubirán National Institute of Health Sciences and Nutrition
(författare)
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Sanchez-Guerrero, JorgeMount Sinai Hospital of University of Toronto
(författare)
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Bernatsky, SashaMcGill University Health Center
(författare)
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Wallace, Daniel J.Cedars-Sinai Medical Center
(författare)
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Isenberg, David A.University College London
(författare)
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Rahman, AnisurUniversity College London
(författare)
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Merrill, Joan T.Oklahoma Medical Research Foundation
(författare)
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Fortin, Paul R.Laval University
(författare)
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Gladman, Dafna D.University of Toronto
(författare)
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Bruce, Ian N.Manchester University NHS Foundation Trust,University of Manchester
(författare)
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Petri, Michelle A.Johns Hopkins University School of Medicine
(författare)
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Ginzler, Ellen M.
(författare)
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Dooley, Mary AnneUniversity of North Carolina
(författare)
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Ramsey-Goldman, RosalindNorthwestern University Feinberg School of Medicine
(författare)
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Manzi, SusanAllegheny Health Network
(författare)
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Jönsen, AndreasLund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lund SLE Research Group,Forskargrupper vid Lunds universitet,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups(Swepub:lu)reum-ajo
(författare)
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Van Vollenhoven, Ronald F.University of Amsterdam
(författare)
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Aranow, CynthiaFeinstein Institute for Medical Research
(författare)
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Mackay, MegganFeinstein Institute for Medical Research
(författare)
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Ruiz-Irastorza, GuillermoHospital de Cruces
(författare)
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Lim, S. SamEmory University
(författare)
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Inanc, Murat
(författare)
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Kalunian, Kenneth C.University of California, San Diego
(författare)
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Jacobsen, SørenCopenhagen University Hospital
(författare)
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Peschken, Christine A.University of Manitoba
(författare)
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Kamen, Diane L.Medical University of South Carolina
(författare)
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Askanase, AncaColumbia University
(författare)
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Pons-Estel, Bernardo A.Grupo Oroño-Centro Regional de Enfermedades Autoinmunes y Reumáticas (GO-CREAR)
(författare)
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Cardwell, Francesca S.University of Waterloo
(författare)
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Alarcón, Graciela S.
(författare)
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Clarke, Ann E.Cumming School of Medicine
(författare)
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Cumming School of MedicineHospital Nacional Guillermo Almenara Irigoyen, EsSalud
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Annals of the Rheumatic Diseases0003-4967
Internetlänk
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Till lärosätets databas
- Av författaren/redakt...
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Barber, Megan R. ...
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Ugarte-Gil, Manu ...
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Hanly, John G.
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Urowitz, Murray ...
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St-Pierre, Yvan
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Gordon, Caroline
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visa fler...
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Bae, Sang Cheol
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Romero-Diaz, Jua ...
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Sanchez-Guerrero ...
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Bernatsky, Sasha
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Wallace, Daniel ...
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Isenberg, David ...
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Rahman, Anisur
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Merrill, Joan T.
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Fortin, Paul R.
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Gladman, Dafna D ...
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Bruce, Ian N.
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Petri, Michelle ...
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Ginzler, Ellen M ...
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Dooley, Mary Ann ...
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Ramsey-Goldman, ...
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Manzi, Susan
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Jönsen, Andreas
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Van Vollenhoven, ...
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Aranow, Cynthia
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Mackay, Meggan
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Ruiz-Irastorza, ...
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Lim, S. Sam
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Inanc, Murat
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Kalunian, Kennet ...
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Jacobsen, Søren
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Peschken, Christ ...
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Kamen, Diane L.
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Askanase, Anca
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Pons-Estel, Bern ...
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Cardwell, France ...
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Alarcón, Graciel ...
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Clarke, Ann E.
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