Sökning: WFRF:(Kamen Diane) >
Remission and low d...
Remission and low disease activity are associated with lower healthcare costs : results from the Systemic Lupus International Collaborating Clinics (SLICC) inception cohort
-
- Barber, Megan R.W. (författare)
- Cumming School of Medicine
-
- Ugarte-Gil, Manuel Francisco (författare)
- Hospital Nacional Guillermo Almenara Irigoyen, EsSalud,Scientific University of the South, Lima
-
- Hanly, John G. (författare)
- Dalhousie University
-
visa fler...
-
- Urowitz, Murray B. (författare)
- Toronto Western Hospital
-
- St-Pierre, Yvan (författare)
- McGill University Health Center
-
Gordon, Caroline (författare)
-
- Bae, Sang Cheol (författare)
- Hanyang University Hospital for Rheumatic Disease
-
- Romero-Diaz, Juanita (författare)
- Salvador Zubirán National Institute of Health Sciences and Nutrition
-
- Sanchez-Guerrero, Jorge (författare)
- Mount Sinai Hospital of University of Toronto
-
- Bernatsky, Sasha (författare)
- McGill University Health Center
-
- Wallace, Daniel J. (författare)
- Cedars-Sinai Medical Center
-
- Isenberg, David A. (författare)
- University College London
-
- Rahman, Anisur (författare)
- University College London
-
- Merrill, Joan T. (författare)
- Oklahoma Medical Research Foundation
-
- Fortin, Paul R. (författare)
- Laval University
-
- Gladman, Dafna D. (författare)
- University of Toronto
-
- Bruce, Ian N. (författare)
- University of Manchester,Manchester University NHS Foundation Trust
-
- Petri, Michelle A. (författare)
- Johns Hopkins University School of Medicine
-
Ginzler, Ellen M. (författare)
-
- Dooley, Mary Anne (författare)
- University of North Carolina
-
- Ramsey-Goldman, Rosalind (författare)
- Northwestern University Feinberg School of Medicine
-
- Manzi, Susan (författare)
- Allegheny Health Network
-
- Jönsen, Andreas (författare)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lund SLE Research Group,Forskargrupper vid Lunds universitet,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups
-
- Van Vollenhoven, Ronald F. (författare)
- University of Amsterdam
-
- Aranow, Cynthia (författare)
- Feinstein Institute for Medical Research
-
- Mackay, Meggan (författare)
- Feinstein Institute for Medical Research
-
- Ruiz-Irastorza, Guillermo (författare)
- Hospital de Cruces
-
- Lim, S. Sam (författare)
- Emory University
-
Inanc, Murat (författare)
-
- Kalunian, Kenneth C. (författare)
- University of California, San Diego
-
- Jacobsen, Søren (författare)
- Copenhagen University Hospital
-
- Peschken, Christine A. (författare)
- University of Manitoba
-
- Kamen, Diane L. (författare)
- Medical University of South Carolina
-
- Askanase, Anca (författare)
- Columbia University
-
- Pons-Estel, Bernardo A. (författare)
- Grupo Oroño-Centro Regional de Enfermedades Autoinmunes y Reumáticas (GO-CREAR)
-
- Cardwell, Francesca S. (författare)
- University of Waterloo
-
Alarcón, Graciela S. (författare)
-
- Clarke, Ann E. (författare)
- Cumming School of Medicine
-
visa färre...
-
(creator_code:org_t)
- 2024
- 2024
- Engelska.
-
Ingår i: Annals of the Rheumatic Diseases. - 0003-4967.
- Relaterad länk:
-
http://dx.doi.org/10...
-
visa fler...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Objectives: This study aims to determine the independent impact of definitions of remission/low disease activity (LDA) on direct/indirect costs (DCs, ICs) in a multicentre inception cohort. Methods: Patients from 31 centres in 10 countries were enrolled within 15 months of diagnosis and assessed annually. Five mutually exclusive disease activity states (DAS) were defined as (1) remission off-treatment: clinical (c) SLEDAI-2K=0, without prednisone/immunosuppressants; (2) remission on-treatment: cSLEDAI-2K=0, prednisone ≤5 mg/day and/or maintenance immunosuppressants; (3) LDA-Toronto Cohort (TC): cSLEDAI-2K≤2, without prednisone/immunosuppressants; (4) modified lupus LDA state (mLLDAS): SLEDAI-2K≤4, no activity in major organs/systems, no new activity, prednisone ≤7.5 mg/day and/or maintenance immunosuppressants and (5) active: all remaining assessments. At each assessment, patients were stratified into the most stringent DAS fulfilled and the proportion of time in a DAS since cohort entry was determined. Annual DCs/ICs (2021 Canadian dollars) were based on healthcare use and lost workforce/non-workforce productivity over the preceding year. The association between the proportion of time in a DAS and annual DC/IC was examined through multivariable random-effects linear regressions. Results: 1692 patients were followed a mean of 9.7 years; 49.0% of assessments were active. Remission/LDA (per 25% increase in time in a remission/LDA state vs active) were associated with lower annual DC/IC: remission off-treatment (DC -$C1372; IC -$C2507), remission on-treatment (DC -$C973; IC -$C2604,) LDA-TC (DC -$C1158) and mLLDAS (DC -$C1040). There were no cost differences between remission/LDA states. Conclusions: Our data suggest that systemic lupus erythematosus patients who achieve remission, both off and on-therapy, and reductions in disease activity incur lower costs than those experiencing persistent disease activity.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Nyckelord
- Economics
- Epidemiology
- Health services research
- Lupus Erythematosus, Systemic
- Risk Factors
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Barber, Megan R. ...
-
Ugarte-Gil, Manu ...
-
Hanly, John G.
-
Urowitz, Murray ...
-
St-Pierre, Yvan
-
Gordon, Caroline
-
visa fler...
-
Bae, Sang Cheol
-
Romero-Diaz, Jua ...
-
Sanchez-Guerrero ...
-
Bernatsky, Sasha
-
Wallace, Daniel ...
-
Isenberg, David ...
-
Rahman, Anisur
-
Merrill, Joan T.
-
Fortin, Paul R.
-
Gladman, Dafna D ...
-
Bruce, Ian N.
-
Petri, Michelle ...
-
Ginzler, Ellen M ...
-
Dooley, Mary Ann ...
-
Ramsey-Goldman, ...
-
Manzi, Susan
-
Jönsen, Andreas
-
Van Vollenhoven, ...
-
Aranow, Cynthia
-
Mackay, Meggan
-
Ruiz-Irastorza, ...
-
Lim, S. Sam
-
Inanc, Murat
-
Kalunian, Kennet ...
-
Jacobsen, Søren
-
Peschken, Christ ...
-
Kamen, Diane L.
-
Askanase, Anca
-
Pons-Estel, Bern ...
-
Cardwell, France ...
-
Alarcón, Graciel ...
-
Clarke, Ann E.
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Reumatologi och ...
- Artiklar i publikationen
-
Annals of the Rh ...
- Av lärosätet
-
Lunds universitet