Clinical associations with venous thromboembolism in anti-neutrophil cytoplasm antibody-associated vasculitides

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Kronbichler, AndreasAddenbrooke's Hospital,Medical University of Innsbruck (author)

Clinical associations with venous thromboembolism in anti-neutrophil cytoplasm antibody-associated vasculitides

Article/chapterEnglish2017

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2017-01-03
Oxford University Press (OUP),2017
5 s.

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LIBRIS-ID:oai:lup.lub.lu.se:d96aeb07-0529-4397-b1fc-213e0c48252a
https://lup.lub.lu.se/record/d96aeb07-0529-4397-b1fc-213e0c48252aURI
https://doi.org/10.1093/rheumatology/kew465DOI

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Language:English
Summary in:English

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Objective. To assess potential associations for the development of venous thromboembolic events in patients with ANCA-associated vasculitides (AAV). Methods. Four hundred and seventeen patients enrolled to participate in randomized controlled trials conducted by the European Vasculitis Society were identified. Univariate and multivariate analyses were performed to validate previously proposed and identify novel risks associated with venous thromboembolism (VTE) in AAV. Results. VTE occurred in 41 of 417 (9.8%) patients. Uncorrected univariate analysis identified BVAS (odds ratio, OR= 1.05, 95% CI: 1.01, 1.10; P = 0.013), subsequent development of malignancy (OR = 2.6, 95% CI: 1.19, 5.71; P = 0.017), mucous membrane or eye involvement (OR = 2.13, 95% CI: 1.10, 4.11; P = 0.024) and baseline creatinine (OR = 1.08, 95% CI: 0.99, 1.18; P = 0.037) as being associated with the development of VTE. Multivariate analysis highlighted CRP (per 10 mg/l increase, OR= 1.05, 95% CI: 1.01, 1.09; P = 0.025), cutaneous involvement (OR = 4.83, 95% CI: 1.63, 14.38; P = 0.005) and gastrointestinal involvement (OR = 6.27, 95% CI: 1.34, 29.37; P = 0.02) among the BVAS items as well as baseline creatinine (per 100 mmol/l increase, OR= 1.17, 95% CI: 1.02, 1.35; P = 0.029) as being associated with VTEs. Conclusion. Our results highlight a role of CRP, baseline creatinine, and cutaneous and gastrointestinal involvement in the risk stratification as being associated with thromboembolic events. Moreover, there might be an association between VTEs and subsequent development of malignancy and disease activity in general.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Reumatologi och inflammation hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Rheumatology and Autoimmunity hsv//eng
ANCA
Deep venous thrombosis
Malignancy
Pulmonary embolism
Vasculitis
Venous thromboembolism

Added entries (persons, corporate bodies, meetings, titles ...)

Leierer, JohannesMedical University of Innsbruck (author)
Leierer, GiselaMedical University of Innsbruck (author)
Mayer, GertMedical University of Innsbruck (author)
Casian, AlinaGuy's and St Thomas' NHS Foundation Trust (author)
Höglund, PeterLund University,Lunds universitet,Avdelningen för klinisk kemi och farmakologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Chemistry and Pharmacology,Department of Laboratory Medicine,Faculty of Medicine,Skåne University Hospital(Swepub:lu)kfar-pho (author)
Westman, KerstinLund University,Lunds universitet,Njurmedicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Autoimmunitet och njursjukdomar,Forskargrupper vid Lunds universitet,Nephrology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Autoimmunity and kidney diseases,Lund University Research Groups(Swepub:lu)njur-kwe (author)
Jayne, DavidAddenbrooke's Hospital (author)
Addenbrooke's HospitalMedical University of Innsbruck (creator_code:org_t)

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In:Rheumatology: Oxford University Press (OUP)56:5, s. 704-7081462-03241462-0332

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