Sökning: L773:0161 5505 OR L773:1535 5667 OR L773:2159 662X
> (1975-1979) >
Labeling and testin...
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Persson, B. R.R.Lund University,Lunds universitet,Medicinsk strålningsfysik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medical Radiation Physics, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine
(författare)
Labeling and testing of (99m)Tc streptokinase for the diagnosis of deep vein thrombosis
- Artikel/kapitelEngelska1975
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LIBRIS-ID:oai:lup.lub.lu.se:d9be062f-af6c-4637-b079-41d7a7b32435
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https://lup.lub.lu.se/record/d9be062f-af6c-4637-b079-41d7a7b32435URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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A detailed study has been made of the method for labeling streptokinase with 99Tc(m) in order to get a radioactive indicator for rapid scintigraphic visualization of thrombi and emboli. The best method found for preparing 99Tc(m) streptokinase was by reducing 99Tc(m) pertechnetate with 2 μmole SnCl2 at pH 0.7 and then adding 50,000 to 75,000 IU of streptokinase at a final pH of about 2. After 1 hr of equilibration, the labeling efficiency was 75 to 80% as determined by the method of gel chromatography column scanning. The dynamic behavior and distribution of 99Tc(m) streptokinase in different organs was studied in rabbits where a high uptake was found in liver. In a clinical investigation using 99Tc(m) streptokinase prepared according to this work, however, the liver uptake in man was only 10 to 20%.
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Kempi, V.Lund University
(författare)
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Medicinsk strålningsfysik, LundSektion V
(creator_code:org_t)
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Ingår i:Journal of Nuclear Medicine16:6, s. 474-4770161-5505
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