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Circulating pro-neu...
Circulating pro-neurotensin levels predict bodyweight gain and metabolic alterations in children
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- Barchetta, Ilaria (författare)
- Sapienza University of Rome
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- Bertoccini, Laura (författare)
- Sapienza University of Rome
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- Sentinelli, Federica (författare)
- Sapienza University of Rome,University of L'Aquila
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- Bailetti, Diego (författare)
- Sapienza University of Rome,University of L'Aquila
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- Marini, Giacomo (författare)
- University of Cagliari
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- Cimini, Flavia Agata (författare)
- Sapienza University of Rome
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- Ceccarelli, Valentina (författare)
- Sapienza University of Rome
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- Struck, Joachim (författare)
- Sphingotec GmbH
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- Schulte, Janin (författare)
- Sphingotec GmbH
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- Loche, Sandro (författare)
- Regional Hospital For Microcitemia
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- Cossu, Efisio (författare)
- University of Cagliari
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- Melander, Olle (författare)
- Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups,Skåne University Hospital
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- Cavallo, Maria G. (författare)
- Sapienza University of Rome
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- Baroni, Marco G. (författare)
- University of L'Aquila,Istituto Neurologico Mediterraneo Neuromed
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(creator_code:org_t)
- Elsevier BV, 2021
- 2021
- Engelska.
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Ingår i: Nutrition, Metabolism and Cardiovascular Diseases. - : Elsevier BV. - 0939-4753. ; 31:3, s. 902-910
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background and aims: Neurotensin (NT) is an intestinal peptide released after fat ingestion, which regulates appetite and facilitates lipid absorption. Elevated plasma levels of its stable precursor pro-neurotensin (pro-NT) are associated with type 2 diabetes, obesity and cardiovascular mortality in adult populations; no data on pro-NT and metabolic disease are available in children. Aim of the study was to evaluate plasma pro-NT in relation to the presence of obesity in children, and to test if high pro-NT associates with the development of metabolic impairment later in life. Methods and results: For this longitudinal retrospective study, we studied 151 overweight/obese children undergoing metabolic evaluations at University of Cagliari, Italy. Pro-NT was also assessed in 46 normal-weight, age-, sex-comparable normal-weight children, selected as a reference group. At the baseline, pro-NT was comparable between overweight/obese and normal-weight children and correlated positively with age (p < 0.001), triglycerides (p < 0.001) and inversely with HDL levels (p = 0.008). Plasma pro-NT associated with high triglycerides with OR = 5.9 (95%CI: 1.24–28.1; p = 0.026) after adjustment for multiple confounders. At the 6.5-year follow-up, high basal pro-NT associated with impaired β-cell function to compensate for insulin-resistance (disposition index: r = −0.19, p = 0.035) and predicted bodyweight increase, as indicated by percentage change of standard deviation score BMI (median(95%CI) = +20.8(+4.9-+27.5)% in the highest tertile), independently from age, sex, triglycerides and insulin-resistance (standardized β = 0.24; p = 0.036). Conclusions: Elevated pro-NT levels in children are significantly associated with weight gain later in life and may represent a marker of susceptibility to metabolic impairment in presence of obesity.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- Disposition index
- Insulin-resistance
- Neurotensin
- Obesity
- pro-NT
- Triglycerides
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- Av författaren/redakt...
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Barchetta, Ilari ...
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Bertoccini, Laur ...
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Sentinelli, Fede ...
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Bailetti, Diego
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Marini, Giacomo
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Cimini, Flavia A ...
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visa fler...
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Ceccarelli, Vale ...
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Struck, Joachim
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Schulte, Janin
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Loche, Sandro
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Cossu, Efisio
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Melander, Olle
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Cavallo, Maria G ...
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Baroni, Marco G.
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Näringslära
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Endokrinologi oc ...
- Artiklar i publikationen
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Nutrition, Metab ...
- Av lärosätet
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Lunds universitet