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> (2015) >
Bystander hyperacti...
Bystander hyperactivation of preimmune CD8(+) T cells in chronic HCV patients
- Article/chapterEnglish2015
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LIBRIS-ID:oai:lup.lub.lu.se:da3aa51b-78c1-4d13-adfe-22d04e54604e
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https://lup.lub.lu.se/record/8235492URI
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https://doi.org/10.7554/eLife.07916DOI
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Chronic infection perturbs immune homeostasis. While prior studies have reported dysregulation of effector and memory cells, little is known about the effects on naïve T cell populations. We performed a cross-sectional study of chronic hepatitis C (cHCV) patients using tetramer-associated magnetic enrichment to study antigen-specific inexperienced CD8(+) T cells (i.e., tumor or unrelated virus-specific populations in tumor-free and sero-negative individuals). cHCV showed normal precursor frequencies, but increased proportions of memory-phenotype inexperienced cells, as compared to healthy donors or cured HCV patients. These observations could be explained by low surface expression of CD5, a negative regulator of TCR signaling. Accordingly, we demonstrated TCR hyperactivation and generation of potent CD8(+) T cell responses from the altered T cell repertoire of cHCV patients. In sum, we provide the first evidence that naïve CD8(+) T cells are dysregulated during cHCV infection, and establish a new mechanism of immune perturbation secondary to chronic infection.
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Added entries (persons, corporate bodies, meetings, titles ...)
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Nicoli, Francesco
(author)
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Sultanik, Philippe
(author)
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Flecken, Tobias
(author)
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Perot, Brieuc
(author)
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Duffy, Darragh
(author)
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Bianchi, Elisabetta
(author)
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Lim, Annick
(author)
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Clave, Emmanuel
(author)
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van Buuren, Marit M
(author)
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Schnuriger, Aurélie
(author)
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Johnsson, KerstinLund University,Lunds universitet,Matematik LTH,Matematikcentrum,Institutioner vid LTH,Lunds Tekniska Högskola,Mathematics (Faculty of Engineering),Centre for Mathematical Sciences,Departments at LTH,Faculty of Engineering, LTH(Swepub:lu)math-kij
(author)
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Boussier, Jeremy
(author)
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Garbarg-Chenon, Antoine
(author)
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Bousquet, Laurence
(author)
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Mottez, Estelle
(author)
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Schumacher, Ton N
(author)
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Toubert, Antoine
(author)
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Appay, Victor
(author)
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Heshmati, Farhad
(author)
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Thimme, Robert
(author)
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Pol, Stanislas
(author)
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Mallet, Vincent
(author)
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Albert, Matthew L
(author)
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Matematik LTHMatematikcentrum
(creator_code:org_t)
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Alanio, Cécile
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Nicoli, Francesc ...
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Sultanik, Philip ...
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Flecken, Tobias
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Perot, Brieuc
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Duffy, Darragh
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Bianchi, Elisabe ...
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Lim, Annick
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Clave, Emmanuel
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van Buuren, Mari ...
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Schnuriger, Auré ...
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Johnsson, Kersti ...
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Boussier, Jeremy
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Garbarg-Chenon, ...
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Bousquet, Lauren ...
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Mottez, Estelle
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Schumacher, Ton ...
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Toubert, Antoine
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Appay, Victor
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Heshmati, Farhad
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Thimme, Robert
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Pol, Stanislas
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Mallet, Vincent
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Albert, Matthew ...
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- MEDICAL AND HEALTH SCIENCES
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eLife
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Lund University