Search: id:"swepub:oai:lup.lub.lu.se:da72f8f0-077c-49f2-b594-210a9bff0d14" >
Combined Estrogen A...
-
Topi, GerioldaLund University,Lunds universitet,Cellpatologi, Malmö,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Cell Pathology, Malmö,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital
(author)
Combined Estrogen Alpha and Beta Receptor Expression Has a Prognostic Significance for Colorectal Cancer Patients
- Article/chapterEnglish2022
Publisher, publication year, extent ...
-
2022-03-14
-
Frontiers Media SA,2022
Numbers
-
LIBRIS-ID:oai:lup.lub.lu.se:da72f8f0-077c-49f2-b594-210a9bff0d14
-
https://lup.lub.lu.se/record/da72f8f0-077c-49f2-b594-210a9bff0d14URI
-
https://doi.org/10.3389/fmed.2022.739620DOI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:art swepub-publicationtype
-
Subject category:ref swepub-contenttype
Notes
-
We reported that high estrogen receptor beta (ERβ) expression is independently associated with better prognosis in female colorectal cancer (CRC) patients. However, estrogen receptor alpha (ERα) is expressed at very low levels in normal colon mucosa, and its prognostic role in CRC has not been explored. Herein, we investigated the combined role of ERα and ERβ expression in the prognosis of female patients with CRC, which, to the best of our knowledge, is the first study to investigate this topic. A total number of 306 primary CRCs were immunostained for ERα and ERβ expression. A Cox regression model was used to evaluate overall survival (OS) and disease-free survival (DFS). The combined expression of high ERβ + negative ERα correlates with longer OS (HR = 0.23; 95% CI: 0.11–0.45, P <0.0001) and DFS (HR = 0.10; 95% CI: 0.03–0.26, P < 0.0001) and a more favorable tumor outcome, as well as significantly higher expression of antitumorigenic proteins than combined expression of low ERβ + positive ERα. Importantly, we found that low ERβ expression was associated with local recurrence of CRC, whereas ERα expression was correlated with liver metastasis. Overall, our results show that the combined high ERβ + negative ERα expression correlated with a better prognosis for CRC patients. Our results suggest that the combined expression of ERα and ERβ could be used as a predictive combination marker for CRC patients, especially for predicting DFS.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Ghatak, SouvikLund University,Lunds universitet,Cellpatologi, Malmö,Forskargrupper vid Lunds universitet,Cell Pathology, Malmö,Lund University Research Groups,Skåne University Hospital(Swepub:lu)so1872gh
(author)
-
Satapathy, Shakti RanjanLund University,Lunds universitet,Cellpatologi, Malmö,Forskargrupper vid Lunds universitet,Cell Pathology, Malmö,Lund University Research Groups,Skåne University Hospital(Swepub:lu)sh3321sa
(author)
-
Ehrnström, RoyLund University,Lunds universitet,Patologi, Malmö,Forskargrupper vid Lunds universitet,Pathology, Malmö,Lund University Research Groups,Skåne University Hospital(Swepub:lu)pat-reh
(author)
-
Lydrup, Marie LouiseLund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups,Skåne University Hospital(Swepub:lu)med-msl
(author)
-
Sjölander, AnitaLund University,Lunds universitet,Cellpatologi, Malmö,Forskargrupper vid Lunds universitet,Cell Pathology, Malmö,Lund University Research Groups,Skåne University Hospital(Swepub:lu)expp-asj
(author)
-
Cellpatologi, MalmöForskargrupper vid Lunds universitet
(creator_code:org_t)
Related titles
-
In:Frontiers in Medicine: Frontiers Media SA92296-858X
Internet link
Find in a library
To the university's database