The Hidden Side of Complement Regulator C4BP : Dissection and Evaluation of Its Immunomodulatory Activity

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Search: id:"swepub:oai:lup.lub.lu.se:daa49fd6-b2c7-4a45-af27-870ce7227d84" > The Hidden Side of ...

1 of 1
Previous record
Next record
To hitlist

Details
MARC

Serrano, InmaculadaBellvitge University Hospital-IDIBELL (author)

The Hidden Side of Complement Regulator C4BP : Dissection and Evaluation of Its Immunomodulatory Activity

Article/chapterEnglish2022

Publisher, publication year, extent ...

2022-04-25
Frontiers Media SA,2022

Numbers

LIBRIS-ID:oai:lup.lub.lu.se:daa49fd6-b2c7-4a45-af27-870ce7227d84
https://lup.lub.lu.se/record/daa49fd6-b2c7-4a45-af27-870ce7227d84URI
https://doi.org/10.3389/fimmu.2022.883743DOI

Supplementary language notes

Language:English
Summary in:English

Part of subdatabase

SwePubSwePub

Classification

Subject category:art swepub-publicationtype
Subject category:ref swepub-contenttype

Notes

C4b-binding protein (C4BP) is a well-known regulator of the complement system that holds additional and important activities unrelated to complement inhibition. Recently, we have described a novel immunomodulatory activity in the minor C4BP(β-) isoform directly acting over inflammatory phagocytes. Here we show that incorporation of the β-chain to the C4BP α-chain oligomer interferes with this immunomodulatory activity of C4BP. Moreover, an oligomeric form including only the complement control protein 6 (CCP6) domain of the C4BP α-chain (PRP6-HO7) is sufficient to “reprogram” monocyte-derived DCs (Mo-DCs) from a pro-inflammatory and immunogenic phenotype to an anti-inflammatory and tolerogenic state. PRP6-HO7 lacks complement regulatory activity but retains full immunomodulatory activity over inflammatory Mo-DCs induced by TLRs, characterized by downregulation of relevant surface markers such as CD83, HLA-DR, co-stimulatory molecules such as CD86, CD80 and CD40, and pro-inflammatory cytokines such as IL-12 and TNF-α. Furthermore, PRP6-HO7-treated Mo-DCs shows increased endocytosis, significantly reduced CCR7 expression and CCL21-mediated chemotaxis, and prevents T cell alloproliferation. Finally, PRP6-HO7 shows also full immunomodulatory activity over Mo-DCs isolated from lupus nephritis patients with active disease, even without further pro-inflammatory stimulation. Therefore PRP6-HO7, retaining the immunomodulatory activity of C4BP(β-) and lacking its complement regulatory activity, might represent a promising and novel alternative to treat autoimmune diseases.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Immunologi inom det medicinska området hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Immunology in the medical area hsv//eng
C4BP(β-)
dendritic cells
immunomodulation
inflammation
lupus nephritis
PRP6-HO7

Added entries (persons, corporate bodies, meetings, titles ...)

Luque, AnaBellvitge University Hospital-IDIBELL (author)
Mitjavila, FrancescaBellvitge University Hospital-IDIBELL (author)
Blom, Anna M.Lund University,Lunds universitet,Institutionen för translationell medicin,Medicinska fakulteten,Proteinkemi, Malmö,Forskargrupper vid Lunds universitet,Department of Translational Medicine,Faculty of Medicine,Protein Chemistry, Malmö,Lund University Research Groups(Swepub:lu)klke-abl (author)
Rodríguez de Córdoba, SantiagoCSIC Spanish National Research Council (author)
Vega, M. CristinaCSIC Spanish National Research Council (author)
Torras, JoanBellvitge University Hospital-IDIBELL (author)
Aran, Josep M.Bellvitge University Hospital-IDIBELL (author)
Bellvitge University Hospital-IDIBELLInstitutionen för translationell medicin (creator_code:org_t)

Related titles

In:Frontiers in Immunology: Frontiers Media SA131664-3224

Internet link

Find in a library

Frontiers in Immunology (Search for host publication in LIBRIS)

To the university's database

1 of 1
Previous record
Next record
To hitlist

Find more in SwePub

By the author/editor: Serrano, Inmacul ...; Luque, Ana; Mitjavila, Franc ...; Blom, Anna M.; Rodríguez de Cór ...; Vega, M. Cristin ...; show more...; Torras, Joan; Aran, Josep M.; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Immunology in th ...

Articles in the publication: Frontiers in Imm ...

By the university: Lund University

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se