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Dimethylguanidino valeric acid is a marker of liver fat and predicts diabetes

O’Sullivan, John F. (author)
University of Sydney,Massachusetts General Hospital
Morningstar, Jordan E. (author)
Harvard Medical School
Yang, Qiong (author)
Boston University,National Heart Lung and Blood Institute
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Zheng, Baohui (author)
Harvard Medical School,Massachusetts General Hospital
Gao, Yan (author)
University of Mississippi Medical Center
Jeanfavre, Sarah (author)
Broad Institute
Scott, Justin (author)
Broad Institute
Fernandez, Celine (author)
Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups
Zheng, Hui (author)
Harvard Medical School,Massachusetts General Hospital
O’Connor, Sean (author)
Rockefeller University
Cohen, Paul (author)
Rockefeller University
Vasan, Ramachandran S. (author)
Boston University,National Heart Lung and Blood Institute
Long, Michelle T. (author)
Boston University
Wilson, James G. (author)
University of Mississippi Medical Center
Melander, Olle (author)
Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups,Skåne University Hospital
Wang, Thomas J. (author)
Vanderbilt University
Fox, Caroline (author)
National Heart Lung and Blood Institute,Boston University
Peterson, Randall T. (author)
Massachusetts General Hospital,Harvard Medical School
Clish, Clary B. (author)
Broad Institute
Corey, Kathleen E. (author)
Massachusetts General Hospital
Gerszten, Robert E. (author)
Broad Institute,Harvard Medical School
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 (creator_code:org_t)
2017
2017
English 9 s.
In: Journal of Clinical Investigation. - 0021-9738. ; 127:12, s. 4394-4402
Related links:
http://dx.doi.org/10...
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https://lup.lub.lu.s...
https://doi.org/10.1...
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Unbiased, “nontargeted” metabolite profiling techniques hold considerable promise for biomarker and pathway discovery, in spite of the lack of successful applications to human disease. By integrating nontargeted metabolomics, genetics, and detailed human phenotyping, we identified dimethylguanidino valeric acid (DMGV) as an independent biomarker of CT-defined nonalcoholic fatty liver disease (NAFLD) in the offspring cohort of the Framingham Heart Study (FHS) participants. We verified the relationship between DMGV and early hepatic pathology. Specifically, plasma DMGV levels were correlated with biopsy-proven nonalcoholic steatohepatitis (NASH) in a hospital cohort of individuals undergoing gastric bypass surgery, and DMGV levels fell in parallel with improvements in post-procedure cardiometabolic parameters. Further, baseline DMGV levels independently predicted future diabetes up to 12 years before disease onset in 3 distinct human cohorts. Finally, we provide all metabolite peak data consisting of known and unidentified peaks, genetics, and key metabolic parameters as a publicly available resource for investigations in cardiometabolic diseases.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)

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