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  • Bennett, Jennifer A.University of Chicago Medical Center (författare)

A Distinctive Adnexal (Usually Paratubal) Neoplasm Often Associated with Peutz-Jeghers Syndrome and Characterized by STK11 Alterations (STK11 Adnexal Tumor) : A Report of 22 Cases

  • Artikel/kapitelEngelska2021

Förlag, utgivningsår, omfång ...

  • 2021

Nummerbeteckningar

  • LIBRIS-ID:oai:lup.lub.lu.se:dad871a0-51c6-451d-8d46-bd0c17c282ba
  • https://lup.lub.lu.se/record/dad871a0-51c6-451d-8d46-bd0c17c282baURI
  • https://doi.org/10.1097/PAS.0000000000001677DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

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Klassifikation

  • Ämneskategori:art swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype

Anmärkningar

  • We describe 22 examples of a novel, usually paratubal, adnexal tumor associated with Peutz-Jeghers syndrome in nearly 50% of cases that harbored STK11 alterations in all tested (n=21). The patients ranged from 17 to 66 years (median=39 y) and the tumors from 4.5 to 25.5 cm (median=11 cm). Most (n=18) were paratubal, with metastases noted in 11/22 (50%) and recurrences in 12/15 (80%). Morphologically, they were characterized by interanastomosing cords and trabeculae of predominantly epithelioid cells, set in a variably prominent myxoid to focally edematous stroma, that often merged to form tubular, cystic, cribriform, and microacinar formations, reminiscent of salivary gland-type tumors. The tumor cells were uniformly atypical, often with prominent nucleoli and a variable mitotic index (median=9/10 HPFs). The tumors were usually positive to a variable extent for epithelial (CAM5.2, AE1/AE3, cytokeratin 7), sex cord (calretinin, inhibin, WT1), and mesothelial (calretinin, D2-40) markers, as well as hormone receptors. PAX8, SF1, and GATA-3 were rarely positive, while claudin-4, FOXL2, and TTF-1 were consistently negative. All sequenced tumors (n=21) harbored alterations in STK11, often with a loss of heterozygosity event. There were no other recurrently mutated genes. Recurrent copy number alterations included loss of 1p and 11q, and gain of 1q, 15q, and 15p. Despite an extensive morphologic, immunohistochemical, and molecular evaluation, we are unable to determine with certainty the histogenesis of this unique tumor. Wolffian, sex cord stromal, epithelial, and mesothelial origins were considered. We propose the term STK11 adnexal tumor to describe this novel entity and emphasize the importance of genetic counseling in these patients as a significant number of neoplasms occur in association with Peutz-Jeghers syndrome.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Young, Robert H.Harvard University,Massachusetts General Hospital (författare)
  • Howitt, Brooke E.Stanford University (författare)
  • Croce, SabrinaInstitut Bergoníe (författare)
  • Wanjari, PankhuriUniversity of Chicago Medical Center (författare)
  • Zhen, ChaojieUniversity of Chicago Medical Center (författare)
  • Da Cruz Paula, ArnaudMemorial Sloan-Kettering Cancer Center (författare)
  • Meserve, EmilySpectrum Healthcare Partners (författare)
  • Schoolmeester, J. KennethMayo Clinic Minnesota (författare)
  • Westbom-Fremer, SofiaLund University,Lunds universitet,Bröst- och ovarialcancer,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Breast and Ovarian Cancer Genomics,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments(Swepub:lu)so4231we (författare)
  • Benzi, EduardoBaylor College of Medicine (författare)
  • Patil, Ninad M.Baylor College of Medicine (författare)
  • Kooreman, LoesMaastricht University Medical Centre (författare)
  • El-Bahrawy, MonaImperial College London (författare)
  • Zannoni, Gian FrancoCatholic University of the Sacred Heart, Rome (författare)
  • Krausz, ThomasUniversity of Chicago Medical Center (författare)
  • McCluggage, W. GlennBelfast City Hospital (författare)
  • Weigelt, BrittaMemorial Sloan-Kettering Cancer Center (författare)
  • Ritterhouse, Lauren L.Harvard University,Massachusetts General Hospital (författare)
  • Oliva, EstherHarvard University,Massachusetts General Hospital (författare)
  • University of Chicago Medical CenterHarvard University (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:American Journal of Surgical Pathology45:8, s. 1061-10740147-5185

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