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Galectin-3 is eleva...
Galectin-3 is elevated in CSF and is associated with Aβ deposits and tau aggregates in brain tissue in Alzheimer’s disease
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- Boza-serrano, Antonio (författare)
- Lund University,Lunds universitet,Neuroinflammation,Forskargrupper vid Lunds universitet,Lund University Research Groups,Hospital Clínic of Barcelona,University Hospital Virgen del Rocío
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- Vrillon, Agathe (författare)
- Université Paris Cité
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- Minta, Karolina (författare)
- University of Gothenburg
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- Paulus, Agnes (författare)
- Lund University,Lunds universitet,NanoLund: Centre for Nanoscience,Annan verksamhet, LTH,Lunds Tekniska Högskola,Medicinsk mikrospektroskopi,Forskargrupper vid Lunds universitet,Other operations, LTH,Faculty of Engineering, LTH,Medical Microspectroscopy,Lund University Research Groups
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- Camprubí-ferrer, Lluís (författare)
- Lund University,Lunds universitet,Neuroinflammation,Forskargrupper vid Lunds universitet,Lund University Research Groups
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- Garcia, Megg (författare)
- Lund University,Lunds universitet,Neuroinflammation,Forskargrupper vid Lunds universitet,Lund University Research Groups
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- Andreasson, Ulf (författare)
- University of Gothenburg,Sahlgrenska University Hospital
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- Antonell, Anna (författare)
- University of Barcelona
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- Wennström, Malin (författare)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups
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- Gouras, Gunnar (författare)
- Lund University,Lunds universitet,Experimentell demensforskning,Forskargrupper vid Lunds universitet,Experimental Dementia Research,Lund University Research Groups
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- Dumurgier, Julien (författare)
- Université Paris Cité
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- Cognat, Emmanuel (författare)
- Université Paris Cité
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- Molina-porcel, Laura (författare)
- University of Barcelona,Hospital Clínic of Barcelona
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- Balasa, Mircea (författare)
- Hospital Clínic of Barcelona,University of Barcelona
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- Vitorica, Javier (författare)
- CIBER Enfermedades Neurodegenerativas (CIBERNED),University Hospital Virgen del Rocío
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- Sánchez-valle, Raquel (författare)
- Hospital Clínic of Barcelona,University of Barcelona
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- Paquet, Claire (författare)
- Université Paris Cité
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- Venero, Jose Luis (författare)
- University of Seville,University Hospital Virgen del Rocío
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- Blennow, Kaj (författare)
- University of Gothenburg,Sahlgrenska University Hospital
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- Deierborg, Tomas (författare)
- Lund University,Lunds universitet,Neuroinflammation,Forskargrupper vid Lunds universitet,Lund University Research Groups
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(creator_code:org_t)
- 2022-07-27
- 2022
- Engelska.
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Ingår i: Acta Neuropathologica. - : Springer Science and Business Media LLC. - 1432-0533 .- 0001-6322.
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Galectin-3 (Gal-3) is a beta-galactosidase binding protein involved in microglial activation in the central nervous system(CNS). We previously demonstrated the crucial deleterious role of Gal-3 in microglial activation in Alzheimer’s disease(AD). Under AD conditions, Gal-3 is primarily expressed by microglial cells clustered around Aβ plaques in both humanand mouse brain, and knocking out Gal-3 reduces AD pathology in AD-model mice. To further unravel the importance ofGal-3-associated infammation in AD, we aimed to investigate the Gal-3 infammatory response in the AD continuum. First,we measured Gal-3 levels in neocortical and hippocampal tissue from early-onset AD patients, including genetic and sporadiccases. We found that Gal-3 levels were signifcantly higher in both cortex and hippocampus in AD subjects. Immunohistochemistry revealed that Gal-3+microglial cells were associated with amyloid plaques of a larger size and more irregularshape and with neurons containing tau-inclusions. We then analyzed the levels of Gal-3 in cerebrospinal fuid (CSF) fromAD patients (n=119) compared to control individuals (n=36). CSF Gal-3 levels were elevated in AD patients comparedto controls and more strongly correlated with tau (p-Tau181 and t-tau) and synaptic markers (GAP-43 and neurogranin)than with amyloid-β. Lastly, principal component analysis (PCA) of AD biomarkers revealed that CSF Gal-3 clustered andassociated with other CSF neuroinfammatory markers, including sTREM-2, GFAP, and YKL-40. This neuroinfammatory component was more highly expressed in the CSF from amyloid-β positive (A+), CSF p-Tau181 positive (T+), andbiomarker neurodegeneration positive/negative (N+/−) (A+T+N+/−) groups compared to the A+T−N− group. Overall,Gal-3 stands out as a key pathological biomarker of AD pathology that is measurable in CSF and, therefore, a potential targetfor disease-modifying therapies involving the neuroinfammatory response.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
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- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Boza-serrano, An ...
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Vrillon, Agathe
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Minta, Karolina
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Paulus, Agnes
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Camprubí-ferrer, ...
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Garcia, Megg
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visa fler...
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Andreasson, Ulf
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Antonell, Anna
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Wennström, Malin
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Gouras, Gunnar
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Dumurgier, Julie ...
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Cognat, Emmanuel
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Molina-porcel, L ...
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Balasa, Mircea
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Vitorica, Javier
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Sánchez-valle, R ...
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Paquet, Claire
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Venero, Jose Lui ...
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Blennow, Kaj
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Deierborg, Tomas
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Neurovetenskaper
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Acta Neuropathol ...
- Av lärosätet
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Lunds universitet