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Oral fungal profili...
Oral fungal profiling and risk of nasopharyngeal carcinoma : a population-based case-control study
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- Chen, Yufeng (författare)
- Karolinska Institutet,Karolinska Institute
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- Li, Wanxin (författare)
- Fujian Medical University
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- Chang, Ellen T (författare)
- University of California, Los Angeles
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- Debelius, Justine W (författare)
- Johns Hopkins Bloomberg School of Public Health
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- Manoharan, Lokeshwaran (författare)
- Lund University,Lunds universitet,EPI@LUND,Forskargrupper vid Lunds universitet,Lund University Research Groups
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- Zheng, Yuming (författare)
- Wuzhou Cancer Center
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- Li, Yancheng (författare)
- Wuzhou Red Cross Hospital
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- Huang, Guangwu (författare)
- First Affiliated Hospital of Guangxi Medical University
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- Adami, Hans-Olov (författare)
- Karolinska Institutet,University of Oslo
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- Knight, Rob (författare)
- University of California, San Diego
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- Cai, Yonglin (författare)
- Wuzhou Cancer Center
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- Zhang, Zhe (författare)
- First Affiliated Hospital of Guangxi Medical University
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- Ye, Weimin (författare)
- Karolinska Institutet,Fujian Medical University
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(creator_code:org_t)
- 2023
- 2023
- Engelska.
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Ingår i: EBioMedicine. - 2352-3964. ; 96
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
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- BACKGROUND: Dysbiosis of the oral mycobiome has been linked to some diseases, including cancers. However, the role of oral fungal communities in nasopharyngeal carcinoma (NPC) carcinogenesis has not previously been investigated.METHODS: We characterized the oral salivary fungal mycobiome in 476 untreated incident NPC patients and 537 population-based controls using fungal internal transcribed spacer (ITS)-2 sequencing. The relationship between oral fungal mycobiome and the risk of NPC was assessed through bioinformatic and biostatistical analyses.FINDINGS: We found that lower fungal alpha diversity was associated with an increased odds of NPC [lower vs. higher: observed features (adjusted odds ratio [OR] = 5.81, 95% confidence interval [CI] = 3.60-9.38); Simpson diversity (1.53, 1.03-2.29); Shannon diversity (2.03, 1.35-3.04)]. We also observed a significant difference in global fungal community patterns between cases and controls based on Bray-Curtis dissimilarity (P < 0.001). Carriage of oral fungal species, specifically, Saccharomyces cerevisiae, Candida tropicalis, Lodderomyces elongisporus, Candida albicans, and Fusarium poae, was associated with significantly higher odds of NPC, with ORs ranging from 1.56 to 4.66. Individuals with both low fungal and low bacterial alpha diversity had a profoundly elevated risk of NPC.INTERPRETATION: Our results suggest that dysbiosis in the oral mycobiome, characterized by a loss of fungal community diversity and overgrowth of several fungal organisms, is associated with a substantially increased risk of NPC.FUNDING: This work was funded by the US National Institutes of Health, the Swedish Research Council, the High-level Talents Research Start-up Project of Fujian Medical University, and the China Scholarship Council.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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Chen, Yufeng
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Li, Wanxin
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Chang, Ellen T
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Debelius, Justin ...
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Manoharan, Lokes ...
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Zheng, Yuming
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visa fler...
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Li, Yancheng
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Huang, Guangwu
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Adami, Hans-Olov
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Knight, Rob
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Cai, Yonglin
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Zhang, Zhe
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Ye, Weimin
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