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Galectin-3 depletio...
Galectin-3 depletion tames pro-tumoural microglia and restrains cancer cells growth
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- Rivera-Ramos, Alberto (författare)
- University Hospital Virgen del Rocío,University of Seville
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- Cruz-Hernández, Luis (författare)
- University Hospital Virgen del Rocío,University of Seville
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- Talaverón, Rocío (författare)
- University Hospital Virgen del Rocío,University of Seville
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- Sánchez-Montero, María Teresa (författare)
- University Hospital Virgen del Rocío,University of Seville
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- García-Revilla, Juan (författare)
- University Hospital Virgen del Rocío,University of Seville
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- Mulero-Acevedo, Marta (författare)
- University Hospital Virgen del Rocío,University of Seville
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- Deierborg, Tomas (författare)
- Lund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Neuroinflammation,Forskargrupper vid Lunds universitet,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Department of Experimental Medical Science,Faculty of Medicine,Lund University Research Groups,LU Profile Area: Proactive Ageing,Lund University Profile areas
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- Venero, José Luis (författare)
- University Hospital Virgen del Rocío,University of Seville
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- Sarmiento Soto, Manuel (författare)
- University of Seville,University Hospital Virgen del Rocío
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(creator_code:org_t)
- 2024
- 2024
- Engelska.
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Ingår i: Cancer Letters. - 0304-3835. ; 591
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Galectin-3 (Gal-3) is a multifunctional protein that plays a pivotal role in the initiation and progression of various central nervous system diseases, including cancer. Although the involvement of Gal-3 in tumour progression, resistance to treatment and immunosuppression has long been studied in different cancer types, mainly outside the central nervous system, its elevated expression in myeloid and glial cells underscores its profound impact on the brain's immune response. In this context, microglia and infiltrating macrophages, the predominant non-cancerous cells within the tumour microenvironment, play critical roles in establishing an immunosuppressive milieu in diverse brain tumours. Through the utilisation of primary cell cultures and immortalised microglial cell lines, we have elucidated the central role of Gal-3 in promoting cancer cell migration, invasion, and an immunosuppressive microglial phenotypic activation. Furthermore, employing two distinct in vivo models encompassing primary (glioblastoma) and secondary brain tumours (breast cancer brain metastasis), our histological and transcriptomic analysis show that Gal-3 depletion triggers a robust pro-inflammatory response within the tumour microenvironment, notably based on interferon-related pathways. Interestingly, this response is prominently observed in tumour-associated microglia and macrophages (TAMs), resulting in the suppression of cancer cells growth.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Brain metastasis
- Galectin-3
- Glioblastoma
- Microglia
- Tumour-associated microglia and macrophages (TAMs)
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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