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Prognostic implicat...
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Jerkeman, MatsLund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
(författare)
Prognostic implications of BCL6 rearrangement in uniformly treated patients with diffuse large B-cell lymphoma--a Nordic Lymphoma Group study.
- Artikel/kapitelEngelska2002
Förlag, utgivningsår, omfång ...
Nummerbeteckningar
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LIBRIS-ID:oai:lup.lub.lu.se:dd3c1cf3-397d-4d51-9756-a22b261e6272
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https://lup.lub.lu.se/record/107004URI
Kompletterande språkuppgifter
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Språk:engelska
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Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
Anmärkningar
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The purpose of this study was to investigate the prognostic implications of BCL6 rearrangement in a uniformly treated population of patients with diffuse large B-cell lymphoma (DLBCL) and to characterise the relationship between BCL6 rearrangement and prognostic factors. A total of 269 patients with DLBCL entered a randomised trial comparing the chemotherapy regimen CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone) to the MACOP-B (methotrexate, doxorubicin, cyclophosphamide, vincristine, prednisone, bleomycin) regimen. In 44 cases, frozen tissue was available for assessment of BCL6 status by Southern blot analysis. BCL6 was rearranged in six of 43 evaluable cases (14%), and was associated with elevated lactate dehydrogenase (LDH), and a higher patient age. No association between BCL6 status and expression of BCL2, Ki-67 or TP53 was found. Patients presenting with BCL6 rearrangement displayed a weak trend towards better overall and failure-free survival (67 and 67% at 5 years), compared to patients with germline BCL6 (63 and 52%), but the difference was not statistically significant. In accordance with previously published series, the presence of BCL6 rearrangement does not define a prognostically distinct subgroup of DLBCL. Assessment of BCL6 status may, however, be of clinical interest when related to other prognostic variables.
Ämnesord och genrebeteckningar
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MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
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MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
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Gene Rearrangement B-Lymphocyte : genetics
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Human
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Immunophenotyping
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Lymphoma B-Cell : drug therapy : genetics
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Leucovorin : therapeutic use
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Lactate Dehydrogenase : metabolism
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Lymphoma Large-Cell Diffuse : drug therapy : genetics
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Male
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Methotrexate : therapeutic use
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Middle Age
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Neoplasm Staging
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Prednisone : therapeutic use
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Prognosis
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Proto-Oncogene Proteins : genetics
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Support Non-U.S. Gov't
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Vincristine : therapeutic use
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Transcription Factors : genetics
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Doxorubicin : therapeutic use
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DNA-Binding Proteins : genetics
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DNA Neoplasm : analysis : metabolism
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Cyclophosphamide : therapeutic use
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Blotting Southern
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Bleomycin : therapeutic use
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Antineoplastic Combined Chemotherapy Protocols : therapeutic use
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Aged
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Adolescence
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Adult
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Aman, P
(författare)
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Cavallin-Ståhl, EvaLund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)onk-ecs
(författare)
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Torlakovic, E
(författare)
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Åkerman, MånsLund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)pat-mak
(författare)
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Mitelman, FelixLund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)kgen-fmi
(författare)
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Fioretos, ThoasLund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)kgen-tfi
(författare)
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Bröstcancer-genetikSektion I
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:International Journal of Oncology20:1, s. 161-1651019-6439
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