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- Bentzer, PeterLund University,Lunds universitet,Cirkulationsfysiologi vid kritisk sjukdom,Forskargrupper vid Lunds universitet,Fluid resuscitation in critical illness,Lund University Research Groups (author)
Isolated Brain Trauma in Cats Triggers Rapid Onset of Hypovolemia
- Article/chapterEnglish2017
Publisher, publication year, extent ...
- 2016-11-07
- Springer Science and Business Media LLC,2017
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- LIBRIS-ID:oai:lup.lub.lu.se:ddb862e9-e6dd-4cbe-b6dc-c63f62e43824
- https://lup.lub.lu.se/record/ddb862e9-e6dd-4cbe-b6dc-c63f62e43824URI
- https://doi.org/10.1007/s12028-016-0348-5DOI
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- Language:English
- Summary in:English
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- SwePubSwePub
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- Background: Hemodynamic instability responsive to fluid resuscitation is common after a traumatic brain injury (TBI), also in the absence of systemic hemorrhage. The present study tests if an isolated severe TBI induces a decrease in plasma volume (PV). Methods: The study was performed in three groups of anesthetized and tracheostomized male cats (n = 21). In one group (n = 8), the cats were prepared with a cranial borehole (10 mm i.d) used to expose the brain to a fluid percussion brain injury (FPI) (1.90–2.20 bar), and two smaller cranial boreholes (4 mm i.d) for insertion of an intracranial pressure (ICP) and a microdialysis catheter. To differentiate the effect of FPI from that of the surgical preparation, a sham group was exposed to the same surgical preparation but no FPI trauma (n = 8). A control group had no brain trauma and no surgical preparation (n = 5). PV was determined by a 125I-albumin dilution technique. PV, electrolytes, pH, BE (base excess), hematocrit (Hct), PaO2, and PaCO2 were measured at baseline and after 3 h. Mean arterial pressure (MAP) was measured continuously. ICP was measured in the FPI and the sham group. Results: In the FPI group, PV decreased by 11.2 mL/kg from 31.7 mL/kg (p < 0.01) with a simultaneous increase in Hct and decrease in pH. In the sham group, PV decreased by 5.7 mL/kg from 32.7 mL/kg (p < 0.01). The control group showed no PV reduction. Conclusions: The results support that an isolated severe head trauma triggers a significant and rapid reduction in PV, most likely due to vascular leak.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Anestesi och intensivvård hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Anesthesiology and Intensive Care hsv//eng
- Blood pressure
- Fluid percussion trauma
- Intracranial pressure
- Plasma volume
- Traumatic brain injury
- Vascular leak
Added entries (persons, corporate bodies, meetings, titles ...)
- Grände, Per OlofLund University,Lunds universitet,Cirkulationsfysiologi vid kritisk sjukdom,Forskargrupper vid Lunds universitet,Fluid resuscitation in critical illness,Lund University Research Groups(Swepub:lu)mphy-pog (author)
- Cirkulationsfysiologi vid kritisk sjukdomForskargrupper vid Lunds universitet (creator_code:org_t)
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- In:Neurocritical Care: Springer Science and Business Media LLC26:3, s. 450-4561541-69331556-0961
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