Allergic contact dermatitis caused by isobornyl acrylate in Freestyle® Libre, a newly introduced glucose sensor

Background: Glucose sensors, such as FreeStyle® Libre, are innovative medical devices developed for diabetes patients as a replacement for classic glucose meters, ensuring continuous glucose monitoring without the disadvantage of regular skin finger pricks. Objectives: To report several cases of allergic contact dermatitis caused by FreeStyle® Libre, and to report on isobornyl acrylate as a culprit allergen. Patients and Methods: Fifteen patients presented with allergic contact dermatitis caused by FreeStyle® Libre. All but 1 were patch tested with a baseline series, and with pieces and/or ultrasonic bath extracts of (the adhesive part of) the glucose sensor. Isobornyl acrylate was patch tested, in various concentrations and vehicles, in 13 patients. Gas chromatography–mass spectrometry (GC-MS) of the sensors was performed. Results: All patients reacted to the adhesive part of the sensor, and 12 patients were shown to be sensitized to isobornyl acrylate. Simultaneous reactions to other allergens were rarely observed. GC-MS showed the presence of isobornyl acrylate in the sensors. Conclusions: Cases of allergic contact dermatitis caused by FreeStyle® Libre are increasingly being observed, and isobornyl acrylate is a relevant culprit allergen. Cross-reactivity to other acrylates was infrequently observed, but other, hitherto unidentified, contact allergens may still be present in the device.

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Dermatologi och venereologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Dermatology and Venereal Diseases hsv//eng
acrylates
adhesive
allergic contact dermatitis
CAS no. 5888-33-5
diabetes mellitus
FreeStyle® Libre
gas chromatography
glucose sensor
isobornyl acrylate
mass spectrometry
medical device
sesquiterpene lactone mix

Aerts, OlivierUniversity of Antwerp,Antwerp University Hospital (författare)
Baeck, MarieSaint-Luc University Hospital (författare)
Bruze, MagnusLund University,Lunds universitet,Yrkes- och miljödermatologi,Forskargrupper vid Lunds universitet,Occupational and Environmental Dermatology,Lund University Research Groups,Skåne University Hospital(Swepub:lu)derm-mbr (författare)
De Block, ChristopheAntwerp University Hospital,University of Antwerp (författare)
Goossens, AnCatholic University of Leuven,University Hospitals Leuven (författare)
Hamnerius, NilsLund University,Lunds universitet,Yrkes- och miljödermatologi,Forskargrupper vid Lunds universitet,Occupational and Environmental Dermatology,Lund University Research Groups,Skåne University Hospital(Swepub:lu)med-nlh (författare)
Huygens, SaraUniversity Hospitals Leuven,Catholic University of Leuven (författare)
Maiter, DominiqueSaint-Luc University Hospital (författare)
Tennstedt, DominiqueSaint-Luc University Hospital (författare)
Vandeleene, BernardSaint-Luc University Hospital (författare)
Mowitz, MartinLund University,Lunds universitet,Yrkes- och miljödermatologi,Forskargrupper vid Lunds universitet,Occupational and Environmental Dermatology,Lund University Research Groups,Skåne University Hospital(Swepub:lu)med-mmw (författare)
Saint-Luc University HospitalUniversity of Antwerp (creator_code:org_t)

Av författaren/redakt...: Herman, Anne; Aerts, Olivier; Baeck, Marie; Bruze, Magnus; De Block, Christ ...; Goossens, An; visa fler...; Hamnerius, Nils; Huygens, Sara; Maiter, Dominiqu ...; Tennstedt, Domin ...; Vandeleene, Bern ...; Mowitz, Martin; visa färre...

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