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Carbon dioxide flooding to reduce postoperative neurological injury following surgery for acute type A aortic dissection : a prospective, randomised, blinded, controlled clinical trial, CARTA study protocol - objectives and design

Ede, Jacob (author)
Lund University,Lunds universitet,Neurologiska skador vid akut aortadissektion typ A,Forskargrupper vid Lunds universitet,Neurological injury in acute type A aortic dissection,Lund University Research Groups,Skåne University Hospital
Teurneau-Hermansson, Karl (author)
Lund University,Lunds universitet,Neurologiska skador vid akut aortadissektion typ A,Forskargrupper vid Lunds universitet,Neurological injury in acute type A aortic dissection,Lund University Research Groups,Skåne University Hospital
Moseby-Knappe, Marion (author)
Lund University,Lunds universitet,Brain Injury After Cardiac Arrest,Forskargrupper vid Lunds universitet,Neurologiska skador vid akut aortadissektion typ A,Lund University Research Groups,Neurological injury in acute type A aortic dissection,Skåne University Hospital
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Ramgren, Birgitta (author)
Lund University,Lunds universitet,Neuroradiologi,Forskargrupper vid Lunds universitet,Stroke Imaging Research group,Neurologiska skador vid akut aortadissektion typ A,Neuroradiology,Lund University Research Groups,Neurological injury in acute type A aortic dissection,Skåne University Hospital
Bjursten, Henrik (author)
Lund University,Lunds universitet,Skonsammare hjärtkirurgi,Forskargrupper vid Lunds universitet,Less invasive cardiac surgery,Lund University Research Groups,Skåne University Hospital
Ederoth, Per (author)
Lund University,Lunds universitet,Skonsammare hjärtkirurgi,Forskargrupper vid Lunds universitet,Thoraxanestesi och intensivvård,Less invasive cardiac surgery,Lund University Research Groups,Cardiothoracic anesthesia and intensive care,Skåne University Hospital
Larsson, Mårten (author)
Lund University,Lunds universitet,Minimalinvasiv hjärtkirurgi vid hjärtklaffsjukdom,Forskargrupper vid Lunds universitet,Blödningsrubbningar och akut typ-A dissektion,Neurologiska skador vid akut aortadissektion typ A,Minimal invasive cardiac surgery in valvular heart disease,Lund University Research Groups,Bleeding disorders and acute typ-A dissection,Neurological injury in acute type A aortic dissection,Skåne University Hospital
Mattsson-Carlgren, Niklas (author)
Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Brain Injury After Cardiac Arrest,WCMM- Wallenberg center för molekylär medicinsk forskning,Medicinska fakulteten,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Clinical Memory Research,Lund University Research Groups,WCMM-Wallenberg Centre for Molecular Medicine,Faculty of Medicine,LU Profile Area: Proactive Ageing,Lund University Profile areas,Skåne University Hospital
Sjögren, Johan (author)
Lund University,Lunds universitet,Minimalinvasiv hjärtkirurgi vid hjärtklaffsjukdom,Forskargrupper vid Lunds universitet,Blödningsrubbningar och akut typ-A dissektion,Neurologiska skador vid akut aortadissektion typ A,Minimal invasive cardiac surgery in valvular heart disease,Lund University Research Groups,Bleeding disorders and acute typ-A dissection,Neurological injury in acute type A aortic dissection,Skåne University Hospital
Wierup, Per (author)
Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital
Nozohoor, Shahab (author)
Lund University,Lunds universitet,Minimalinvasiv hjärtkirurgi vid hjärtklaffsjukdom,Forskargrupper vid Lunds universitet,Blödningsrubbningar och akut typ-A dissektion,Neurologiska skador vid akut aortadissektion typ A,Minimal invasive cardiac surgery in valvular heart disease,Lund University Research Groups,Bleeding disorders and acute typ-A dissection,Neurological injury in acute type A aortic dissection,Skåne University Hospital
Zindovic, Igor (author)
Lund University,Lunds universitet,Minimalinvasiv hjärtkirurgi vid hjärtklaffsjukdom,Forskargrupper vid Lunds universitet,Blödningsrubbningar och akut typ-A dissektion,Heparinbindande protein inom thoraxkirurgi,Neurologiska skador vid akut aortadissektion typ A,Minimal invasive cardiac surgery in valvular heart disease,Lund University Research Groups,Bleeding disorders and acute typ-A dissection,Heparin bindning protein in cardiothoracic surgery,Neurological injury in acute type A aortic dissection,Skåne University Hospital
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 (creator_code:org_t)
2023
2023
English.
In: BMJ Open. - 2044-6055. ; 13:5, s. 1-8
Related links:
http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • INTRODUCTION: Neurological complications after surgery for acute type A aortic dissection (ATAAD) increase patient morbidity and mortality. Carbon dioxide flooding is commonly used in open-heart surgery to reduce the risk of air embolism and neurological impairment, but it has not been evaluated in the setting of ATAAD surgery. This report describes the objectives and design of the CARTA trial, investigating whether carbon dioxide flooding reduces neurological injury following surgery for ATAAD. METHODS AND ANALYSIS: The CARTA trial is a single-centre, prospective, randomised, blinded, controlled clinical trial of ATAAD surgery with carbon dioxide flooding of the surgical field. Eighty consecutive patients undergoing repair of ATAAD, and who do not have previous neurological injuries or ongoing neurological symptoms, will be randomised (1:1) to either receive carbon dioxide flooding of the surgical field or not. Routine repair will be performed regardless of the intervention. The primary endpoints are size and number of ischaemic lesions on brain MRI performed after surgery. Secondary endpoints are clinical neurological deficit according to the National Institutes of Health Stroke Scale, level of consciousness using the Glasgow Coma Scale motor score, brain injury markers in blood after surgery, neurological function according to the modified Rankin Scale and postoperative recovery 3 months after surgery. ETHICS AND DISSEMINATION: Ethical approval has been granted by Swedish Ethical Review Agency for this study. Results will be disseminated through peer-reviewed media. TRIAL REGISTRATION NUMBER: NCT04962646.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kirurgi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Surgery (hsv//eng)

Keyword

Cardiac surgery
Cardiothoracic surgery
Stroke

Publication and Content Type

art (subject category)
ref (subject category)

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