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Development of Prec...
Development of Preclinical Ultrasound Imaging Techniques to Identify and Image Sentinel Lymph Nodes in a Cancerous Animal Model
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- Bacou, Marion (author)
- University of Edinburgh
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- Rajasekaran, Vidya (author)
- University of Edinburgh
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- Thomson, Adrian (author)
- University of Edinburgh
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- Sjöstrand, Sandra (author)
- Lund University,Lunds universitet,Avdelningen för Biomedicinsk teknik,Institutionen för biomedicinsk teknik,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Biomedical Engineering,Departments at LTH,Faculty of Engineering, LTH
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- Kaczmarek, Katarzyna (author)
- University of Strathclyde
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- Ochocka-Fox, Anna Maria (author)
- University of Edinburgh
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- Gerrard, Adam D. (author)
- University of Edinburgh
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- Moug, Susan (author)
- Royal Alexandra Hospital, Paisley
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- Jansson, Tomas (author)
- Lund University,Lunds universitet,Avdelningen för Biomedicinsk teknik,Institutionen för biomedicinsk teknik,Institutioner vid LTH,Lunds Tekniska Högskola,Medicinsk teknik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Department of Biomedical Engineering,Departments at LTH,Faculty of Engineering, LTH,Biomedical Engineering, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Region Skåne
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- Mulvana, Helen (author)
- University of Strathclyde
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- Moran, Carmel M. (author)
- University of Edinburgh
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- Farrington, Susan M. (author)
- University of Edinburgh
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(creator_code:org_t)
- 2022-01-22
- 2022
- English.
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In: Cancers. - : MDPI AG. - 2072-6694. ; 14:3
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http://dx.doi.org/10... (free)
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Abstract
Subject headings
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- Lymph nodes (LNs) are believed to be the first organs targeted by colorectal cancer cells detached from a primary solid tumor because of their role in draining interstitial fluids. Better detection and assessment of these organs have the potential to help clinicians in stratification and designing optimal design of oncological treatments for each patient. Whilst highly valuable for the detection of primary tumors, CT and MRI remain limited for the characterization of LNs. B-mode ultrasound (US) and contrast-enhanced ultrasound (CEUS) can improve the detection of LNs and could provide critical complementary information to MRI and CT scans; however, the European Federation of Societies for Ultrasound in Medicine and Biology (EFSUMB) guidelines advise that further evidence is required before US or CEUS can be recommended for clinical use. Moreover, knowledge of the lymphatic system and LNs is relatively limited, especially in preclinical models. In this pilot study, we have created a mouse model of metastatic cancer and utilized 3D high-frequency ultrasound to assess the volume, shape, and absence of hilum, along with CEUS to assess the flow dynamics of tumor-free and tumor-bearing LNs in vivo. The aforementioned parameters were used to create a scoring system to predict the likelihood of a disease-involved LN before establishing post-mortem diagnosis with histopathology. Preliminary results suggest that a sum score of parameters may provide a more accurate diagnosis than the LN size, the single parameter currently used to predict the involvement of an LN in disease.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- 3D ultrasound
- Colorectal cancer
- Contrast-enhanced ultrasound
- Lymph node
- Metastatic mouse model
- Preclinical
Publication and Content Type
- art (subject category)
- ref (subject category)
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Cancers
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- By the author/editor
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Bacou, Marion
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Rajasekaran, Vid ...
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Thomson, Adrian
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Sjöstrand, Sandr ...
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Kaczmarek, Katar ...
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Ochocka-Fox, Ann ...
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show more...
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Gerrard, Adam D.
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Moug, Susan
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Jansson, Tomas
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Mulvana, Helen
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Moran, Carmel M.
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Farrington, Susa ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Cancers
- By the university
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Lund University