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Prostate cancer ris...
Prostate cancer risk SNP rs10993994 is a trans-eQTL for SNHG11 mediated through MSMB
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- Bicak, Mesude (author)
- Icahn School of Medicine at Mount Sinai
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- Wang, Xing (author)
- Icahn School of Medicine at Mount Sinai
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- Gao, Xiaoni (author)
- Icahn School of Medicine at Mount Sinai,Memorial Sloan-Kettering Cancer Center
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- Xu, Xing (author)
- Memorial Sloan-Kettering Cancer Center
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- Väänänen, Riina Minna (author)
- University of Turku
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- Taimen, Pekka (author)
- Turku University Hospital
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- Lilja, Hans (author)
- Lund University,Lunds universitet,Klinisk kemi, Malmö,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Clinical Chemistry, Malmö,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,University of Oxford,Memorial Sloan-Kettering Cancer Center
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- Pettersson, Kim (author)
- University of Turku
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- Klein, Robert J. (author)
- Memorial Sloan-Kettering Cancer Center,Icahn School of Medicine at Mount Sinai
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(creator_code:org_t)
- 2020-02-17
- 2020
- English 11 s.
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In: Human Molecular Genetics. - : Oxford University Press (OUP). - 0964-6906 .- 1460-2083. ; 29:10, s. 1581-1591
- Related links:
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http://dx.doi.org/10...
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https://www.ncbi.nlm...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- How genome-wide association studies-identified single-nucleotide polymorphisms (SNPs) affect remote genes remains unknown. Expression quantitative trait locus (eQTL) association meta-analysis on 496 prostate tumor and 602 normal prostate samples with 117 SNPs revealed novel cis-eQTLs and trans-eQTLs. Mediation testing and colocalization analysis demonstrate that MSMB is a cis-acting mediator for SNHG11 (P < 0.01). Removing rs10993994 in LNCaP cell lines by CRISPR/Cas9 editing shows that the C-allele corresponds with an over 100-fold increase in MSMB expression and 5-fold increase in SNHG11 compared with the T-allele. Colocalization analysis confirmed that the same set of SNPs associated with MSMB expression is associated with SNHG11 expression (posterior probability of shared variants is 66.6% in tumor and 91.4% in benign). These analyses further demonstrate variants driving MSMB expression differ in tumor and normal, suggesting regulatory network rewiring during tumorigenesis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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