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  • Weinhold, Niels (author)

The CCND1 c.870G > A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma

  • Article/chapterEnglish2013

Publisher, publication year, extent ...

  • 2013-03-17
  • Springer Science and Business Media LLC,2013

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:e035bef8-4504-4724-99cd-fe5d35bec984
  • https://lup.lub.lu.se/record/3843820URI
  • https://doi.org/10.1038/ng.2583DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • A number of specific chromosomal abnormalities define the subgroups of multiple myeloma. In a meta-analysis of two genome-wide association studies of multiple myeloma including a total of 1,661 affected individuals, we investigated risk for developing a specific tumor karyotype. The t(11;14)(q13;q32) translocation in which CCND1 is placed under the control of the immunoglobulin heavy chain enhancer was strongly associated with the CCND1 c.870G>A polymorphism (P = 7.96 x 10(-11)). These results provide a model in which a constitutive genetic factor is associated with risk of a specific chromosomal translocation.

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  • Johnson, David C. (author)
  • Chubb, Daniel (author)
  • Chen, Bowang (author)
  • Försti, AstaLund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups(Swepub:lu)med-asf (author)
  • Hosking, Fay J. (author)
  • Broderick, Peter (author)
  • Ma, Yussanne P. (author)
  • Dobbins, Sara E. (author)
  • Hose, Dirk (author)
  • Walker, Brian A. (author)
  • Davies, Faith E. (author)
  • Kaiser, Martin F. (author)
  • Li, Ni L. (author)
  • Gregory, Walter A. (author)
  • Jackson, Graham H. (author)
  • Witzens-Harig, Mathias (author)
  • Neben, Kai (author)
  • Hoffmann, Per (author)
  • Noethen, Markus M. (author)
  • Muehleisen, Thomas W. (author)
  • Eisele, Lewin (author)
  • Ross, Fiona M. (author)
  • Jauch, Anna (author)
  • Goldschmidt, Hartmut (author)
  • Houlston, Richard S. (author)
  • Morgan, Gareth J. (author)
  • Hemminki, KariLund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups(Swepub:lu)med-khk (author)
  • Allmänmedicin och klinisk epidemiologiForskargrupper vid Lunds universitet (creator_code:org_t)

Related titles

  • In:Nature Genetics: Springer Science and Business Media LLC45:5, s. 522-5251546-17181061-4036

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