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WFRF:(Manson JoAnn E)
 

Sökning: WFRF:(Manson JoAnn E) > (2010-2014) > Healthy Lifestyle a...

  • Sun, Qi (författare)

Healthy Lifestyle and Leukocyte Telomere Length in US Women

  • Artikel/kapitelEngelska2012

Förlag, utgivningsår, omfång ...

  • 2012-05-31
  • Public Library of Science (PLoS),2012
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:lup.lub.lu.se:e04bcc52-29c1-4016-9276-2473d693acee
  • https://lup.lub.lu.se/record/2890626URI
  • https://doi.org/10.1371/journal.pone.0038374DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:art swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype

Anmärkningar

  • Context: Whether a healthy lifestyle may be associated with longer telomere length is largely unknown. Objectives: To examine healthy lifestyle practices, which are primary prevention measures against major age-related chronic diseases, in relation to leukocyte telomere length. Design and Setting: Cross-sectional analysis in the Nurses' Health Study (NHS). Participants: The population consisted of 5,862 women who participated in multiple prospective case-control studies within the NHS cohort. Z scores of leukocyte telomere length were derived within each case-control study. Based on prior work, we defined low-risk or healthy categories for five major modifiable factors assessed in 1988 or 1990: non-current smoking, maintaining a healthy body weight (body mass index in 18.5-24.9 kg/m(2)), engaging in regular moderate or vigorous physical activities (>= 150 minutes/week), drinking alcohol in moderation (1 drink/week to,2 drinks/day), and eating a healthy diet (Alternate Healthy Eating Index score in top 50%). We calculated difference (%) of the z scores contrasting low-risk groups with reference groups to evaluate the association of interest. Results: Although none of the individual low-risk factors was significantly associated with larger leukocyte telomere length z scores, we observed a significant, positive relationship between the number of low-risk factors and the z scores. In comparison with women who had zero low-risk factors (1.9% of the total population) and were, therefore, considered the least healthy group, the leukocyte telomere length z scores were 16.4%, 22.1%, 28.7%, 22.6%, and 31.2% (P for trend = 0.015) higher for women who had 1 to 5 low-risk factors, respectively. Conclusions: Adherence to a healthy lifestyle, defined by major modifiable risk factors, was associated with longer telomere length in leukocytes.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Shi, Ling (författare)
  • Prescott, Jennifer (författare)
  • Chiuve, Stephanie E. (författare)
  • Hu, Frank B. (författare)
  • De Vivo, Immaculata (författare)
  • Stampfer, Meir J. (författare)
  • Franks, PaulLund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups(Swepub:lu)med-plf (författare)
  • Manson, Joann E. (författare)
  • Rexrode, Kathryn M. (författare)
  • Genetisk och molekylär epidemiologiForskargrupper vid Lunds universitet (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:PLoS ONE: Public Library of Science (PLoS)7:51932-6203

Internetlänk

Hitta via bibliotek

  • PLoS ONE (Sök värdpublikationen i LIBRIS)

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