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  • Van Calster, Ben (author)

A Novel Approach to Predict the Likelihood of Specific Ovarian Tumor Pathology Based on Serum CA-125: A Multicenter Observational Study.

  • Article/chapterEnglish2011

Publisher, publication year, extent ...

  • 2011

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:e07a57d4-eb18-4452-8f18-2522d60c5e8b
  • https://lup.lub.lu.se/record/2168498URI
  • https://doi.org/10.1158/1055-9965.EPI-11-0422DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • BACKGROUND: The CA-125 tumor marker has limitations when used to distinguish between benign and malignant ovarian masses. We therefore establish likelihood curves of six subgroups of ovarian pathology based on CA-125 and menopausal status.METHODS: This cross-sectional study conducted by the International Ovarian Tumor Analysis group involved 3,511 patients presenting with a persistent adnexal mass that underwent surgical intervention. CA-125 distributions for six tumor subgroups (endometriomas and abscesses, other benign tumors, borderline tumors, stage I invasive cancers, stage II-IV invasive cancers, and metastatic tumors) were estimated using kernel density estimation with stratification for menopausal status. Likelihood curves for the tumor subgroups were derived from the distributions.RESULTS: Endometriomas and abscesses were the only benign pathologies with median CA-125 levels above 20 U/mL (43 and 45, respectively). Borderline and invasive stage I tumors had relatively low median CA-125 levels (29 and 81 U/mL, respectively). The CA-125 distributions of stage II-IV invasive cancers and benign tumors other than endometriomas or abscesses were well separated; the distributions of the other subgroups overlapped substantially. This held for premenopausal and postmenopausal patients. Likelihood curves and reference tables comprehensibly show how subgroup likelihoods change with CA-125 and menopausal status.Conclusions and Impact: Our results confirm the limited clinical value of CA-125 for preoperative discrimination between benign and malignant ovarian pathology. We have shown that CA-125 may be used in a different way. By using likelihood reference tables, we believe clinicians will be better able to interpret preoperative serum CA-125 results in patients with adnexal masses. Cancer Epidemiol Biomarkers Prev; ©2011 AACR.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Valentin, LilLund University,Lunds universitet,Obstetrisk, gynekologisk och prenatal ultraljudsdiagnostik,Forskargrupper vid Lunds universitet,Obstetric, Gynaecological and Prenatal Ultrasound Research,Lund University Research Groups(Swepub:lu)obst-lva (author)
  • Van Holsbeke, Caroline (author)
  • Zhang, Jingjing (author)
  • Jurkovic, Davor (author)
  • Lissoni, Andrea Alberto (author)
  • Testa, Antonia Carla (author)
  • Czekierdowski, Artur (author)
  • Fischerová, Daniela (author)
  • Domali, Ekaterini (author)
  • Van de Putte, Gregg (author)
  • Vergote, Ignace (author)
  • Van Huffel, Sabine (author)
  • Bourne, Tom (author)
  • Timmerman, Dirk (author)
  • Obstetrisk, gynekologisk och prenatal ultraljudsdiagnostikForskargrupper vid Lunds universitet (creator_code:org_t)

Related titles

  • In:Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology20, s. 2420-24281538-7755

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