Human protein HC and its IgA complex are inhibitors of neutrophil chemotaxis

• Protein HC, a heterogeneously charged low molecular weight glycoprotein, and its IgA complex were isolated from human plasma and urine. Plasma from individuals with monoclonal IgA populations was used as starting material for the isolation of the protein HC-IgA complex to obtain homogeneous complex populations. Neither low molecular weight protein HC nor its IgA complex in the concentrations 30 and 600 mg/liter influenced the random migration of normal human neutrophils. The chemotactic response of neutrophils to endotoxin-activated serum was, however, attenuated in a dose-dependent way by both low molecular weight protein HC and protein HC-IgA complex. Concentrations of protein HC and its IgA complex producing significant inhibition of the chemotactic response were found to occur in plasma from healthy and diseased individuals as well as in synovial fluid from patients with rheumatoid arthritis. These results suggest that protein HC and its IgA complex play physiological roles in the regulation of the inflammatory response.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Läkemedelskemi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Medicinal Chemistry (hsv//eng)

Nyckelord

Alpha-Globulins/immunology

Antibodies, Monoclonal/immunology

Antigen-Antibody Complex

Arthritis, Rheumatoid/immunology

Chemotaxis, Leukocyte

Humans

Immunoglobulin A/immunology

In Vitro Techniques

Kidney Failure, Chronic/blood

Neutrophils/immunology

Synovial Fluid/immunology

Publikations- och innehållstyp

art (ämneskategori)

ref (ämneskategori)