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  • Lechman, Eric R (author)

miR-126 Regulates Distinct Self-Renewal Outcomes in Normal and Malignant Hematopoietic Stem Cells.

  • Article/chapterEnglish2016

Publisher, publication year, extent ...

  • Elsevier BV,2016

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:e1407822-759c-46a3-af5a-ceed348f9e92
  • https://lup.lub.lu.se/record/8829996URI
  • https://doi.org/10.1016/j.ccell.2015.12.011DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • To investigate miRNA function in human acute myeloid leukemia (AML) stem cells (LSC), we generated a prognostic LSC-associated miRNA signature derived from functionally validated subpopulations of AML samples. For one signature miRNA, miR-126, high bioactivity aggregated all in vivo patient sample LSC activity into a single sorted population, tightly coupling miR-126 expression to LSC function. Through functional studies, miR-126 was found to restrain cell cycle progression, prevent differentiation, and increase self-renewal of primary LSC in vivo. Compared with prior results showing miR-126 regulation of normal hematopoietic stem cell (HSC) cycling, these functional stem effects are opposite between LSC and HSC. Combined transcriptome and proteome analysis demonstrates that miR-126 targets the PI3K/AKT/MTOR signaling pathway, preserving LSC quiescence and promoting chemotherapy resistance.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Gentner, Bernhard (author)
  • Ng, Stanley W K (author)
  • Schoof, Erwin M (author)
  • van Galen, Peter (author)
  • Kennedy, James A (author)
  • Nucera, Silvia (author)
  • Ciceri, Fabio (author)
  • Kaufmann, Kerstin B (author)
  • Takayama, Naoya (author)
  • Dobson, Stephanie M (author)
  • Trotman-Grant, Aaron (author)
  • Krivdova, Gabriela (author)
  • Elzinga, Janneke (author)
  • Mitchell, Amanda (author)
  • Nilsson, BjörnLund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)klin-bni (author)
  • Hermans, Karin G (author)
  • Eppert, Kolja (author)
  • Marke, Rene (author)
  • Isserlin, Ruth (author)
  • Voisin, Veronique (author)
  • Bader, Gary D (author)
  • Zandstra, Peter W (author)
  • Golub, Todd R (author)
  • Ebert, Benjamin L (author)
  • Lu, Jun (author)
  • Minden, Mark (author)
  • Wang, Jean C Y (author)
  • Naldini, Luigi (author)
  • Dick, John E (author)
  • Avdelningen för hematologi och transfusionsmedicinInstitutionen för laboratoriemedicin (creator_code:org_t)

Related titles

  • In:Cancer Cell: Elsevier BV29:2, s. 214-2281878-36861535-6108

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