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Ultrasound and elas...
Ultrasound and elastography in the assessment of skin involvement in systemic sclerosis : A systematic literature review focusing on validation and standardization – WSF Skin Ultrasound Group
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- Santiago, Tânia (author)
- University of Coimbra,University Hospital of Coimbra
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Santos, Eduardo (author)
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Ruaro, Barbara (author)
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- Lepri, Gemma (author)
- University of Florence
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- Green, Lorraine (author)
- Leeds School of Medicine,Leeds Teaching Hospitals NHS Trust
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- Wildt, Marie (author)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Forskargruppen för systemisk skleros, Lund,Forskargrupper vid Lunds universitet,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund Systemic Sclerosis Research Group,Lund University Research Groups,Skåne University Hospital
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Watanabe, Shinji (author)
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- Lescoat, Alain (author)
- Rennes University Hospital
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- Hesselstrand, Roger (author)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Forskargruppen för systemisk skleros, Lund,Forskargrupper vid Lunds universitet,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund Systemic Sclerosis Research Group,Lund University Research Groups,Skåne University Hospital
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- Galdo, Francesco Del (author)
- Leeds Teaching Hospitals NHS Trust,Leeds School of Medicine
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- Pauling, John D. (author)
- Royal National Hospital for Rheumatic Diseases,University of Bath
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- Iagnocco, Annamaria (author)
- University of Turin
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- da Silva, J. A.P. (author)
- University of Coimbra,University Hospital of Coimbra
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(creator_code:org_t)
- Elsevier BV, 2022
- 2022
- English.
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In: Seminars in Arthritis and Rheumatism. - : Elsevier BV. - 0049-0172. ; 52
- Related links:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
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- Objective: To summarize the published evidence in the literature on the role of ultrasound and elastography to assess skin involvement in systemic sclerosis (SSc). Methods: A systematic literature review (SLR) was performed within the “Skin Ultrasound Working Group” of the World Scleroderma Foundation, according to the Cochrane Handbook. A search was conducted in Pubmed, Cochrane Library and Embase databases from 1/1/1979 to 31/5/2021, using the participants, intervention, comparator and outcomes (PICO) framework. Only full-text articles involving adults, reported in any language, assessing ultrasound to quantify skin pathology in SSc patients. Two reviewers performed the assessment of risk of bias, data extraction and synthesis, independently. Results: Forty-six studies out of 3248 references evaluating skin ultrasound and elastography domains were included. B-mode ultrasound was used in 30 studies (65.2%), elastography in nine (19.6%), and both methods in seven (15.2%). The ultrasound outcome measure domains reported were thickness (57.8%) and echogenicity (17.2%); the elastography domain was stiffness (25%). Methods used for image acquisition and analysis were remarkably heterogeneous and frequently under-reported, precluding data synthesis across studies. The same applies to contextual factors and feasibility. Our data syntheses indicated evidence of good reliability and convergent validity for ultrasound thickness evaluation against mRSS and skin histological findings. Stiffness and echogenicity have limited evidence for validity against histological findings. Evidence for sensitivity to change, test-retest reliability, clinical trial discrimination or thresholds of meaning is limited or absent for reported ultrasound domains. Conclusion: Ultrasound is a valid and reliable tool for skin thickness measurement in SSc but there are significant knowledge gaps regarding skin echogenicity assessment by ultrasound and skin stiffness evaluation by elastography in terms of feasibility, validity and discrimination. Standardization of image acquisition and analysis is needed to foster progress.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Keyword
- Skin elastography
- Skin ultrasound
- Systemic sclerosis
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- ref (subject category)
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- By the author/editor
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Santiago, Tânia
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Santos, Eduardo
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Ruaro, Barbara
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Lepri, Gemma
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Green, Lorraine
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Wildt, Marie
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show more...
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Watanabe, Shinji
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Lescoat, Alain
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Hesselstrand, Ro ...
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Galdo, Francesco ...
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Pauling, John D.
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Iagnocco, Annama ...
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da Silva, J. A.P ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Rheumatology and ...
- Articles in the publication
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Seminars in Arth ...
- By the university
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Lund University