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Genome-wide meta-an...
Genome-wide meta-analyses identify multiple loci associated with smoking behavior
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Furberg, Helena (author)
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Kim, YunJung (author)
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Dackor, Jennifer (author)
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show more...
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Boerwinkle, Eric (author)
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Franceschini, Nora (author)
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Ardissino, Diego (author)
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Bernardinelli, Luisa (author)
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Mannucci, Pier M. (author)
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Mauri, Francesco (author)
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Merlini, Piera A. (author)
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Absher, Devin (author)
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Assimes, Themistocles L. (author)
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Fortmann, Stephen P. (author)
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Iribarren, Carlos (author)
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Knowles, Joshua W. (author)
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Quertermous, Thomas (author)
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Ferrucci, Luigi (author)
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Tanaka, Toshiko (author)
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Bis, Joshua C. (author)
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Furberg, Curt D. (author)
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Haritunians, Talin (author)
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McKnight, Barbara (author)
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Psaty, Bruce M. (author)
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Taylor, Kent D. (author)
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Thacker, Evan L. (author)
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- Almgren, Peter (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
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- Groop, Leif (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
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- Ladenvall, Claes (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
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Boehnke, Michael (author)
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Jackson, Anne U. (author)
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Mohlke, Karen L. (author)
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Stringham, Heather M. (author)
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Tuomilehto, Jaakko (author)
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Benjamin, Emelia J. (author)
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Hwang, Shih-Jen (author)
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Levy, Daniel (author)
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Preis, Sarah Rosner (author)
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Vasan, Ramachandran S. (author)
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Duan, Jubao (author)
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Gejman, Pablo V. (author)
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Levinson, Douglas F. (author)
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Sanders, Alan R. (author)
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Shi, Jianxin (author)
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Lips, Esther H. (author)
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Mckay, James D. (author)
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Agudo, Antonio (author)
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Barzan, Luigi (author)
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Bencko, Vladimir (author)
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Benhamou, Simone (author)
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Castellsague, Xavier (author)
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Canova, Cristina (author)
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Conway, David I. (author)
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Fabianova, Eleonora (author)
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Foretova, Lenka (author)
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Janout, Vladimir (author)
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Healy, Claire M. (author)
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Holcatova, Ivana (author)
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Kjaerheim, Kristina (author)
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Lagiou, Pagona (author)
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Lissowska, Jolanta (author)
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Lowry, Ray (author)
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Macfarlane, Tatiana V. (author)
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Mates, Dana (author)
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Richiardi, Lorenzo (author)
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Rudnai, Peter (author)
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Szeszenia-Dabrowska, Neonilia (author)
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Zaridze, David (author)
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Znaor, Ariana (author)
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Lathrop, Mark (author)
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Brennan, Paul (author)
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Bandinelli, Stefania (author)
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Frayling, Timothy M. (author)
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Guralnik, Jack M. (author)
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Milaneschi, Yuri (author)
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Perry, John R. B. (author)
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Altshuler, David (author)
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Elosua, Roberto (author)
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Kathiresan, Sek (author)
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Lucas, Gavin (author)
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- Melander, Olle (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups
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O'Donnell, Christopher J. (author)
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Salomaa, Veikko (author)
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Schwartz, Stephen M. (author)
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Voight, Benjamin F. (author)
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Penninx, Brenda W. (author)
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Smit, Johannes H. (author)
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Vogelzangs, Nicole (author)
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Boomsma, Dorret I. (author)
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de Geus, Eco J. C. (author)
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Vink, Jacqueline M. (author)
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Willemsen, Gonneke (author)
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Chanock, Stephen J. (author)
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Gu, Fangyi (author)
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Hankinson, Susan E. (author)
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Hunter, David J. (author)
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Hofman, Albert (author)
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Tiemeier, Henning (author)
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Uitterlinden, Andre G. (author)
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van Duijn, Cornelia M. (author)
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Walter, Stefan (author)
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Chasman, Daniel I. (author)
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Everett, Brendan M. (author)
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Pare, Guillaume (author)
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Ridker, Paul M. (author)
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Li, Ming D. (author)
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Maes, Hermine H. (author)
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Audrain-McGovern, Janet (author)
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Posthuma, Danielle (author)
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Thornton, Laura M. (author)
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Lerman, Caryn (author)
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Kaprio, Jaakko (author)
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Rose, Jed E. (author)
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Ioannidis, John P. A. (author)
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Kraft, Peter (author)
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Lin, Dan-Yu (author)
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Sullivan, Patrick F. (author)
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(creator_code:org_t)
- 2010-04-25
- 2010
- English.
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In: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 42:5, s. 134-441
- Related links:
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http://dx.doi.org/10...
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https://europepmc.or...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Consistent but indirect evidence has implicated genetic factors in smoking behavior1,2. We report meta-analyses of several smoking phenotypes within cohorts of the Tobacco and Genetics Consortium (n = 74,053). We also partnered with the European Network of Genetic and Genomic Epidemiology (ENGAGE) and Oxford-GlaxoSmithKline (Ox-GSK) consortia to follow up the 15 most significant regions (n > 140,000). We identified three loci associated with number of cigarettes smoked per day. The strongest association was a synonymous 15q25 SNP in the nicotinic receptor gene CHRNA3 (rs1051730[A], b = 1.03, standard error (s.e.) = 0.053, beta = 2.8 x 10(-73)). Two 10q25 SNPs (rs1329650[G], b = 0.367, s. e. = 0.059, beta = 5.7 x 10(-10); and rs1028936[A], b = 0.446, s. e. = 0.074, beta = 1.3 x 10(-9)) and one 9q13 SNP in EGLN2 (rs3733829[G], b = 0.333, s. e. = 0.058, P = 1.0 x 10(-8)) also exceeded genome-wide significance for cigarettes per day. For smoking initiation, eight SNPs exceeded genome-wide significance, with the strongest association at a nonsynonymous SNP in BDNF on chromosome 11 (rs6265[C], odds ratio (OR) = 1.06, 95% confidence interval (Cl) 1.04-1.08, P = 1.8 x 10(-8)). One SNP located near DBH on chromosome 9 (rs3025343[G], OR = 1.12, 95% Cl 1.08-1.18, P = 3.6 x 10(-8)) was significantly associated with smoking cessation.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
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- By the author/editor
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Furberg, Helena
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Kim, YunJung
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Dackor, Jennifer
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Boerwinkle, Eric
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Franceschini, No ...
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Ardissino, Diego
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show more...
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Bernardinelli, L ...
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Mannucci, Pier M ...
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Mauri, Francesco
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Merlini, Piera A ...
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Absher, Devin
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Assimes, Themist ...
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Fortmann, Stephe ...
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Iribarren, Carlo ...
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Knowles, Joshua ...
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Quertermous, Tho ...
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Ferrucci, Luigi
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Tanaka, Toshiko
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Bis, Joshua C.
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Furberg, Curt D.
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Haritunians, Tal ...
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McKnight, Barbar ...
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Psaty, Bruce M.
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Taylor, Kent D.
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Thacker, Evan L.
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Almgren, Peter
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Groop, Leif
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Ladenvall, Claes
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Boehnke, Michael
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Jackson, Anne U.
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Mohlke, Karen L.
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Stringham, Heath ...
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Tuomilehto, Jaak ...
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Benjamin, Emelia ...
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Hwang, Shih-Jen
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Levy, Daniel
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Preis, Sarah Ros ...
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Vasan, Ramachand ...
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Duan, Jubao
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Gejman, Pablo V.
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Levinson, Dougla ...
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Sanders, Alan R.
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Shi, Jianxin
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Lips, Esther H.
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Mckay, James D.
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Agudo, Antonio
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Barzan, Luigi
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Bencko, Vladimir
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Benhamou, Simone
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Castellsague, Xa ...
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Canova, Cristina
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Conway, David I.
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Fabianova, Eleon ...
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Foretova, Lenka
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Janout, Vladimir
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Healy, Claire M.
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Holcatova, Ivana
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Kjaerheim, Krist ...
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Lagiou, Pagona
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Lissowska, Jolan ...
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Lowry, Ray
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Macfarlane, Tati ...
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Mates, Dana
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Richiardi, Loren ...
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Rudnai, Peter
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Szeszenia-Dabrow ...
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Zaridze, David
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Znaor, Ariana
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Lathrop, Mark
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Brennan, Paul
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Bandinelli, Stef ...
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Frayling, Timoth ...
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Guralnik, Jack M ...
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Milaneschi, Yuri
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Perry, John R. B ...
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Altshuler, David
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Elosua, Roberto
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Kathiresan, Sek
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Lucas, Gavin
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Melander, Olle
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O'Donnell, Chris ...
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Salomaa, Veikko
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Schwartz, Stephe ...
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Voight, Benjamin ...
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Penninx, Brenda ...
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Smit, Johannes H ...
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Vogelzangs, Nico ...
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Boomsma, Dorret ...
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de Geus, Eco J. ...
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Vink, Jacqueline ...
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Willemsen, Gonne ...
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Chanock, Stephen ...
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Gu, Fangyi
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Hankinson, Susan ...
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Hunter, David J.
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Hofman, Albert
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Tiemeier, Hennin ...
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Uitterlinden, An ...
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van Duijn, Corne ...
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Walter, Stefan
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Chasman, Daniel ...
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Everett, Brendan ...
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Pare, Guillaume
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Ridker, Paul M.
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Li, Ming D.
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Maes, Hermine H.
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Audrain-McGovern ...
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Posthuma, Daniel ...
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Thornton, Laura ...
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Lerman, Caryn
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Kaprio, Jaakko
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Rose, Jed E.
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Ioannidis, John ...
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Kraft, Peter
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Lin, Dan-Yu
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Sullivan, Patric ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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Nature Genetics
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Lund University