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Enhanced deposition...
Enhanced deposition of cartilage oligomeric matrix protein is a common feature in fibrotic skin pathologies
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Agarwal, Pallavi (author)
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Schulz, Jan-Niklas (author)
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Blumbach, Katrin (author)
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- Andréasson, Kristofer (author)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Heinegård, Dick (author)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine
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Paulsson, Mats (author)
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Mauch, Cornelia (author)
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Eming, Sabine A. (author)
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Eckes, Beate (author)
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Krieg, Thomas (author)
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(creator_code:org_t)
- Elsevier BV, 2013
- 2013
- English.
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In: Matrix Biology. - : Elsevier BV. - 1569-1802 .- 0945-053X. ; 32:6, s. 325-331
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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Abstract
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- Skin fibrosis is characterized by activated fibroblasts and an altered architecture of the extracellular matrix. Excessive deposition of extracellular matrix proteins and altered cytokine levels in the dermal collagen matrix are common to several pathological situations such as localized scleroderma and systemic sclerosis, keloids, dermatosclerosis associated with venous ulcers and the fibroproliferative tissue surrounding invasively growing tumors. Which factors contribute to altered organization of dermal collagen matrix in skin fibrosis is not well understood. We recently demonstrated that cartilage oligomeric matrix protein (COMP) functions as organizer of the dermal collagen I network in healthy human skin (Agarwal et al., 2012). Here we show that COMP deposition is enhanced in the dermis in various fibrotic conditions. COMP levels were significantly increased in fibrotic lesions derived from patients with localized scleroderma, in wound tissue and exudates of patients with venous leg ulcers and in the fibrotic stroma of biopsies from patients with basal cell carcinoma. We postulate enhanced deposition of COMP as one of the common factors altering the supramolecular architecture of collagen matrix in fibrotic skin pathologies. Interestingly, COMP remained nearly undetectable in normally healing wounds where myofibroblasts transiently accumulate in the granulation tissue. We conclude that COMP expression is restricted to a fibroblast differentiation state not identical to myofibroblasts which is induced by TGF beta and biomechanical forces. (C) 2013 Elsevier B.V. All rights reserved.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Keyword
- COMP
- ECM organization
- Collagen fibrils
- Basal cell carcinoma
- Chronic
- wounds
- Fibroplastic stroma response
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Agarwal, Pallavi
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Schulz, Jan-Nikl ...
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Blumbach, Katrin
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Andréasson, Kris ...
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Heinegård, Dick
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Paulsson, Mats
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show more...
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Mauch, Cornelia
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Eming, Sabine A.
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Eckes, Beate
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Krieg, Thomas
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Rheumatology and ...
- Articles in the publication
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Matrix Biology
- By the university
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Lund University