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Metabolic syndrome,...
Metabolic syndrome, plasma lipid, lipoprotein and glucose levels, and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC)
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Cust, Anne E. (author)
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Kaaks, Rudolf (author)
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Friedenreich, Christine (author)
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show more...
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Bonnet, Fabrice (author)
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Laville, Martine (author)
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Tjonneland, Anne (author)
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Olsen, Anja (author)
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Overvad, Kim (author)
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Jakobsen, Marianne Uhre (author)
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Chajes, Veronique (author)
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Clavel-Chapelon, Frangoise (author)
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Boutron-Ruault, Marie-Christine (author)
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Linseisen, Jakob (author)
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Lukanova, Annekatrin (author)
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Boeing, Heiner (author)
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Pischon, Tobias (author)
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Trichopoulou, Antonia (author)
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Christina, Bamia (author)
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Trichopoulos, Dimitrios (author)
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Palli, Domenico (author)
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Berrino, Franco (author)
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Panico, Salvatore (author)
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Tumino, Rosario (author)
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Sacerdote, Carlotta (author)
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Gram, Inger Torhild (author)
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Lund, Eiliv (author)
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Quiros, J. R. (author)
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Travier, Nomie (author)
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Garcia, Carmen Martinez (author)
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Larranaga, Nerea (author)
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Chirlaque, Maria-Dolores (author)
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Ardanaz, Eva (author)
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- Berglund, Göran (author)
- Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups
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- Lundin, Eva (author)
- Umeå universitet,Patologi
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Bueno-De-Mesquita, H. Bas (author)
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Franzel, J. B. van Duijnhoven (author)
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Peeters, Petra H. M. (author)
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Bingham, Sheila (author)
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Khaw, Kay-Tee (author)
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Allen, Naomi (author)
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Key, Tim (author)
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Ferrari, Pietro (author)
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Rinaldi, Sabina (author)
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Slimani, Nadia (author)
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Riboli, Elio (author)
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(creator_code:org_t)
- 2007
- 2007
- English.
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In: Endocrine-Related Cancer. - 1479-6821 .- 1351-0088. ; 14:3, s. 755-767
- Related links:
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http://dx.doi.org/10... (free)
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http://www.ncbi.nlm....
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
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- To clarify the role of metabolic factors in endometrial carcinogenesis, we conducted a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC), and examined the relation between prediagnostic plasma lipids, lipoproteins, and glucose, the metabolic syndrome (MetS; a cluster of metabolic factors) and endometrial cancer risk. Among pre- and postmenopausal women, 284 women developed endometrial cancer during follow-up. Using risk set sampling, 546 matched control subjects were selected. From conditional logistic regression models, high-density lipoprotein cholesterol (HDL-C) levels were inversely associated with risk body mass index (BMI)-adjusted relative risk (FR) for top versus bottom quartile 0.61 (95% confidence intervals (CI) 0.38-0.97), P-trend= 0.02). Glucose levels were positively associated with risk (BMI-adjusted RR top versus bottom quartile 1.69 (95% Cl 0.99-2.90), P-trend, = 0.03), which appeared stronger among postmenopausal women (BMI-adjusted RR top versus bottom tertile 2.61 (95% Cl 1.46-4.66), P-trend=0.0006, P-heterogeneity=0.13) and never-users of exogenous hormones (P-heterogeneity=0-005 for oral contraceptive (OC) use and 0.05 for hormone replacement therapy-use). The associations of HDL-C and glucose with risk were no longer statistically significant after further adjustment for obesity-related hormones. Plasma total cholesterol, Low-density lipoprotein cholesterol (LDL-C), and triglycerides were not significantly related to overall risk. The presence of MetS was associated with risk (RR 2.12 (95% CI 1.51-2.97)), which increased with the number of MetS factors (P-trend=0.02). An increasing number of MetS factors other than waist circumference, however, was marginally significantly associated with risk only in women with waist circumference above the median (P-interaction=0-01). None of the associations differed significantly by fasting status. These findings suggest that metabolic abnormalities and obesity may act synergistically to increase endometrial cancer risk.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Annan klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Other Clinical Medicine (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Cust, Anne E.
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Kaaks, Rudolf
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Friedenreich, Ch ...
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Bonnet, Fabrice
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Laville, Martine
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Tjonneland, Anne
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show more...
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Olsen, Anja
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Overvad, Kim
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Jakobsen, Marian ...
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Chajes, Veroniqu ...
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Clavel-Chapelon, ...
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Boutron-Ruault, ...
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Linseisen, Jakob
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Lukanova, Anneka ...
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Boeing, Heiner
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Pischon, Tobias
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Trichopoulou, An ...
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Christina, Bamia
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Trichopoulos, Di ...
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Palli, Domenico
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Berrino, Franco
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Panico, Salvator ...
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Tumino, Rosario
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Sacerdote, Carlo ...
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Gram, Inger Torh ...
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Lund, Eiliv
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Quiros, J. R.
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Travier, Nomie
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Garcia, Carmen M ...
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Larranaga, Nerea
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Chirlaque, Maria ...
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Ardanaz, Eva
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Berglund, Göran
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Lundin, Eva
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Bueno-De-Mesquit ...
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Franzel, J. B. v ...
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Peeters, Petra H ...
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Bingham, Sheila
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Khaw, Kay-Tee
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Allen, Naomi
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Key, Tim
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Ferrari, Pietro
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Rinaldi, Sabina
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Slimani, Nadia
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Riboli, Elio
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Other Clinical M ...
- Articles in the publication
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Endocrine-Relate ...
- By the university
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Lund University
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Umeå University