Search: (WFRF:(Berglund M)) pers:(Kaaks Rudolf) pers:(Linseisen Jakob) pers:(Allen Naomi) pers:(Larranaga Nerea)
> (2007) >
Metabolic syndrome,...
Metabolic syndrome, plasma lipid, lipoprotein and glucose levels, and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC)
-
Cust, Anne E. (author)
-
Kaaks, Rudolf (author)
-
Friedenreich, Christine (author)
-
show more...
-
Bonnet, Fabrice (author)
-
Laville, Martine (author)
-
Tjonneland, Anne (author)
-
Olsen, Anja (author)
-
Overvad, Kim (author)
-
Jakobsen, Marianne Uhre (author)
-
Chajes, Veronique (author)
-
Clavel-Chapelon, Frangoise (author)
-
Boutron-Ruault, Marie-Christine (author)
-
Linseisen, Jakob (author)
-
Lukanova, Annekatrin (author)
-
Boeing, Heiner (author)
-
Pischon, Tobias (author)
-
Trichopoulou, Antonia (author)
-
Christina, Bamia (author)
-
Trichopoulos, Dimitrios (author)
-
Palli, Domenico (author)
-
Berrino, Franco (author)
-
Panico, Salvatore (author)
-
Tumino, Rosario (author)
-
Sacerdote, Carlotta (author)
-
Gram, Inger Torhild (author)
-
Lund, Eiliv (author)
-
Quiros, J. R. (author)
-
Travier, Nomie (author)
-
Garcia, Carmen Martinez (author)
-
Larranaga, Nerea (author)
-
Chirlaque, Maria-Dolores (author)
-
Ardanaz, Eva (author)
-
- Berglund, Göran (author)
- Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups
-
- Lundin, Eva (author)
- Umeå universitet,Patologi
-
Bueno-De-Mesquita, H. Bas (author)
-
Franzel, J. B. van Duijnhoven (author)
-
Peeters, Petra H. M. (author)
-
Bingham, Sheila (author)
-
Khaw, Kay-Tee (author)
-
Allen, Naomi (author)
-
Key, Tim (author)
-
Ferrari, Pietro (author)
-
Rinaldi, Sabina (author)
-
Slimani, Nadia (author)
-
Riboli, Elio (author)
-
show less...
-
(creator_code:org_t)
- 2007
- 2007
- English.
-
In: Endocrine-Related Cancer. - 1479-6821 .- 1351-0088. ; 14:3, s. 755-767
- Related links:
-
http://dx.doi.org/10... (free)
-
show more...
-
http://www.ncbi.nlm....
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
show less...
Abstract
Subject headings
Close
- To clarify the role of metabolic factors in endometrial carcinogenesis, we conducted a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC), and examined the relation between prediagnostic plasma lipids, lipoproteins, and glucose, the metabolic syndrome (MetS; a cluster of metabolic factors) and endometrial cancer risk. Among pre- and postmenopausal women, 284 women developed endometrial cancer during follow-up. Using risk set sampling, 546 matched control subjects were selected. From conditional logistic regression models, high-density lipoprotein cholesterol (HDL-C) levels were inversely associated with risk body mass index (BMI)-adjusted relative risk (FR) for top versus bottom quartile 0.61 (95% confidence intervals (CI) 0.38-0.97), P-trend= 0.02). Glucose levels were positively associated with risk (BMI-adjusted RR top versus bottom quartile 1.69 (95% Cl 0.99-2.90), P-trend, = 0.03), which appeared stronger among postmenopausal women (BMI-adjusted RR top versus bottom tertile 2.61 (95% Cl 1.46-4.66), P-trend=0.0006, P-heterogeneity=0.13) and never-users of exogenous hormones (P-heterogeneity=0-005 for oral contraceptive (OC) use and 0.05 for hormone replacement therapy-use). The associations of HDL-C and glucose with risk were no longer statistically significant after further adjustment for obesity-related hormones. Plasma total cholesterol, Low-density lipoprotein cholesterol (LDL-C), and triglycerides were not significantly related to overall risk. The presence of MetS was associated with risk (RR 2.12 (95% CI 1.51-2.97)), which increased with the number of MetS factors (P-trend=0.02). An increasing number of MetS factors other than waist circumference, however, was marginally significantly associated with risk only in women with waist circumference above the median (P-interaction=0-01). None of the associations differed significantly by fasting status. These findings suggest that metabolic abnormalities and obesity may act synergistically to increase endometrial cancer risk.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Annan klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Other Clinical Medicine (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database
- By the author/editor
-
Cust, Anne E.
-
Kaaks, Rudolf
-
Friedenreich, Ch ...
-
Bonnet, Fabrice
-
Laville, Martine
-
Tjonneland, Anne
-
show more...
-
Olsen, Anja
-
Overvad, Kim
-
Jakobsen, Marian ...
-
Chajes, Veroniqu ...
-
Clavel-Chapelon, ...
-
Boutron-Ruault, ...
-
Linseisen, Jakob
-
Lukanova, Anneka ...
-
Boeing, Heiner
-
Pischon, Tobias
-
Trichopoulou, An ...
-
Christina, Bamia
-
Trichopoulos, Di ...
-
Palli, Domenico
-
Berrino, Franco
-
Panico, Salvator ...
-
Tumino, Rosario
-
Sacerdote, Carlo ...
-
Gram, Inger Torh ...
-
Lund, Eiliv
-
Quiros, J. R.
-
Travier, Nomie
-
Garcia, Carmen M ...
-
Larranaga, Nerea
-
Chirlaque, Maria ...
-
Ardanaz, Eva
-
Berglund, Göran
-
Lundin, Eva
-
Bueno-De-Mesquit ...
-
Franzel, J. B. v ...
-
Peeters, Petra H ...
-
Bingham, Sheila
-
Khaw, Kay-Tee
-
Allen, Naomi
-
Key, Tim
-
Ferrari, Pietro
-
Rinaldi, Sabina
-
Slimani, Nadia
-
Riboli, Elio
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Other Clinical M ...
- Articles in the publication
-
Endocrine-Relate ...
- By the university
-
Lund University
-
Umeå University