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The Dynamics of Cir...
The Dynamics of Circulating Heparin-Binding Protein : Implications for Its Use as a Biomarker
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- Fisher, Jane (författare)
- Lund University,Lunds universitet,Translationell Sepsisforskning,Forskargrupper vid Lunds universitet,Translational Sepsis research,Lund University Research Groups
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- Kahn, Fredrik (författare)
- Lund University,Lunds universitet,Lund University Bioimaging Center,Medicinska fakulteten,Neutrofiler – nya mekanismer och nya markörer,Forskargrupper vid Lunds universitet,Faculty of Medicine,Neutrophils – new mechanisms and new biomarkers,Lund University Research Groups
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- Wiebe, Elena (författare)
- University of Veterinary Medicine Hannover,Lund University
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- Gustafsson, Pontus (författare)
- Lund University
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- Kander, Thomas (författare)
- Lund University,Lunds universitet,Klinisk forskning inom anestesi och intensivvårdsmedicin,Forskargrupper vid Lunds universitet,Clinical Research in Anaesthesia and Intensive Care Medicine,Lund University Research Groups,Skåne University Hospital
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- Mellhammar, Lisa (författare)
- Lund University,Lunds universitet,Lund University Bioimaging Center,Medicinska fakulteten,Translationell Sepsisforskning,Forskargrupper vid Lunds universitet,Faculty of Medicine,Translational Sepsis research,Lund University Research Groups
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- Bentzer, Peter (författare)
- Lund University,Lunds universitet,Cirkulationsfysiologi vid kritisk sjukdom,Forskargrupper vid Lunds universitet,Klinisk forskning inom anestesi och intensivvårdsmedicin,Fluid resuscitation in critical illness,Lund University Research Groups,Clinical Research in Anaesthesia and Intensive Care Medicine,Helsingborg Hospital
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- Linder, Adam (författare)
- Lund University,Lunds universitet,Lund University Bioimaging Center,Medicinska fakulteten,Translationell Sepsisforskning,Forskargrupper vid Lunds universitet,SEBRA Sepsis and Bacterial Resistance Alliance,Faculty of Medicine,Translational Sepsis research,Lund University Research Groups
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(creator_code:org_t)
- 2021-12-29
- 2022
- Engelska.
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Ingår i: Journal of Innate Immunity. - : S. Karger AG. - 1662-811X .- 1662-8128. ; 14:5, s. 447-460
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://www.karger.c...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Heparin-binding protein (HBP) is a promising biomarker for the development and severity of sepsis. To guide its use, it is important to understand the factors that could lead to false-positive or negative results, such as inappropriate release and inadequate clearance of HBP. HBP is presumably released only by neutrophils, and the organs responsible for its elimination are unknown. In this study, we aimed to determine whether non-neutrophil cells can be a source of circulating HBP and which organs are responsible for its removal. We found that in two cohorts of neutropenic patients, 12% and 19% of patients in each cohort, respectively, had detectable plasma HBP levels. In vitro, three leukemia-derived monocytic cell lines and healthy CD14+ monocytes constitutively released detectable levels of HBP. When HBP was injected intravenously in rats, we found that plasma levels of HBP decreased rapidly, with a distribution half-life below 10 min and an elimination half-life of 1-2 h. We measured HBP levels in the liver, spleen, kidneys, lungs, and urine using both ELISA and immunofluorescence quantitation, and found that the majority of HBP was present in the liver, and a small amount was present in the spleen. Immunofluorescence imaging indicated that HBP is associated mainly with hepatocytes in the liver and monocytes/macrophages in the spleen. The impact of hematologic malignancies and liver diseases on plasma HBP levels should be explored further in clinical studies.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Anestesi och intensivvård (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Anesthesiology and Intensive Care (hsv//eng)
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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