Search: id:"swepub:oai:lup.lub.lu.se:e342f434-9f14-48ae-befd-33a203660f8b" >
Significance of Isc...
-
Vedin, OlaUppsala universitet,Institutionen för medicinska vetenskaper,Uppsala kliniska forskningscentrum (UCR)
(author)
Significance of Ischemic Heart Disease in Patients with Heart Failure and Preserved, Midrange, and Reduced Ejection Fraction : A Nationwide Cohort Study
- Article/chapterEnglish2017
Publisher, publication year, extent ...
-
LIPPINCOTT WILLIAMS & WILKINS,2017
Numbers
-
LIBRIS-ID:oai:lup.lub.lu.se:e342f434-9f14-48ae-befd-33a203660f8b
-
https://lup.lub.lu.se/record/e342f434-9f14-48ae-befd-33a203660f8bURI
-
https://doi.org/10.1161/CIRCHEARTFAILURE.117.003875DOI
-
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-139190URI
-
http://kipublications.ki.se/Default.aspx?queryparsed=id:136021197URI
-
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-329727URI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:art swepub-publicationtype
-
Subject category:ref swepub-contenttype
Notes
-
Funding Agencies|Swedish National Board of Health and Welfare; Swedish Association of Local Authorities and Regions; Swedish Society of Cardiology; SwedeHF Research Foundation; Swedish Research Council; Swedish Heart-Lung Foundation; Stockholm County Council and Swedish Society of Medicine; Karolinska Institutet Foundation; Mats Kleberg Foundation; National Medical Research Council of Singapore
-
Background - The pathogenic role of ischemic heart disease (IHD) in heart failure (HF) with reduced ejection fraction (HFrEF; EF <40%) is well established, but its pathogenic and prognostic significance in HF with midrange (HFmrEF; EF 40%-50%) and preserved EF (HFpEF; EF ≥50%) has been much less explored. Methods and Results - We evaluated 42 987 patients from the Swedish Heart Failure Registry with respect to baseline IHD, outcomes (IHD, HF, cardiovascular events, and all-cause death), and EF change during a median follow-up of 2.2 years. Overall, 23% had HFpEF (52% IHD), 21% had HFmrEF (61% IHD), and 55% had HFrEF (60% IHD). After multivariable adjustment, associations with baseline IHD were similar for HFmrEF and HFrEF and lower in HFpEF (risk ratio, 0.91 [0.89-0.93] versus HFmrEF and risk ratio, 0.90 [0.88-0.92] versus HFrEF). The adjusted risk of IHD events was similar for HFmrEF versus HFrEF and lower in HFpEF (hazard ratio, 0.89 [0.84-0.95] versus HFmrEF and hazard ratio, 0.84 [0.80-0.90] versus HFrEF). After adjustment, prevalent IHD was associated with increased risk of IHD events and all other outcomes in all EF categories except all-cause mortality in HFpEF. Those with IHD, particularly new IHD events, were also more likely to change to a lower EF category and less likely to change to a higher EF category over time. Conclusions - HFmrEF resembled HFrEF rather than HFpEF with regard to both a higher prevalence of IHD and a greater risk of new IHD events. Established IHD was an important prognostic factor across all HF types.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Lam, Carolyn S PDuke–NUS Medical School,National Heart Centre Singapore, Singapore; Duke NUS Medical Sch, Singapore,Natl Heart Ctr Singapore, Singapore, Singapore.;Duke NUS Med Sch, Singapore, Singapore.
(author)
-
Koh, Angela S.Duke–NUS Medical School,National Heart Centre Singapore, Singapore; Duke NUS Medical Sch, Singapore,Natl Heart Ctr Singapore, Singapore, Singapore.;Duke NUS Med Sch, Singapore, Singapore.
(author)
-
Benson, LinaKarolinska Institutet,Regional Cancer Center Stockholm - Gotland,Reg Canc Ctr Stockholm Gotland, Stockholm, Sweden.
(author)
-
Teng, Tiew Hwa KatherineUniversity of Western Australia, Crawley,National Heart Centre Singapore, Singapore; University of Western Australia, Australia,Natl Heart Ctr Singapore, Singapore, Singapore.;Univ Western Australia, Sch Populat Hlth, Perth, WA, Australia.
(author)
-
Tay, Wan TingNational Heart Centre Singapore, Singapore,Natl Heart Ctr Singapore, Singapore, Singapore.
(author)
-
Braun, Oscar Ö.Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital,Lund University, Sweden,Lund Univ, Skane Univ Hosp, Dept Cardiol, Lund, Sweden.(Swepub:lu)kard-oos
(author)
-
Savarese, GianluigiKarolinska Institutet,Karolinska Institute,Karolinska Institute, Sweden; Karolinska University Hospital, Sweden,Karolinska Inst, Dept Med, Stockholm, Sweden.;Karolinska Univ Hosp, Dept Cardiol, Stockholm, Sweden.
(author)
-
Dahlström, UlfLinköpings universitet,Linköping University,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US,Linkoping Univ, Dept Cardiol, Linkoping, Sweden.;Linkoping Univ, Dept Med & Hlth Sci, Linkoping, Sweden.(Swepub:liu)ulfda85
(author)
-
Lund, Lars HKarolinska Institutet,Karolinska Institute,Karolinska Institute, Sweden; Karolinska University Hospital, Sweden,Karolinska Inst, Dept Med, Stockholm, Sweden.;Karolinska Univ Hosp, Dept Cardiol, Stockholm, Sweden.
(author)
-
Uppsala universitetInstitutionen för medicinska vetenskaper
(creator_code:org_t)
Related titles
-
In:Circulation: Heart Failure: LIPPINCOTT WILLIAMS & WILKINS10:61941-32891941-3297
Internet link
Find in a library
To the university's database
- By the author/editor
-
Vedin, Ola
-
Lam, Carolyn S P
-
Koh, Angela S.
-
Benson, Lina
-
Teng, Tiew Hwa K ...
-
Tay, Wan Ting
-
show more...
-
Braun, Oscar Ö.
-
Savarese, Gianlu ...
-
Dahlström, Ulf
-
Lund, Lars H
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cardiac and Card ...
- Articles in the publication
-
Circulation: Hea ...
- By the university
-
Lund University
-
Linköping University
-
Karolinska Institutet
-
Uppsala University