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Reservoir-excess pr...
Reservoir-excess pressure parameters are independently associated with NT-proBNP in older adults
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- Aizawa, Kunihiko (author)
- University of Exeter
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- Hughes, Alun D (author)
- University College London
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- Casanova, Francesco (author)
- University of Exeter
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- Gooding, Kim M (author)
- University of Exeter
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- Gates, Phillip E (author)
- University of Exeter
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- Mawson, David M (author)
- University of Exeter
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- Williams, Jennifer (author)
- University of Exeter
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- Goncalves, Isabel (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - translationella studier,Forskargrupper vid Lunds universitet,Cardiovascular Research - Translational Studies,Lund University Research Groups,Skåne University Hospital
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- Nilsson, Jan (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - immunitet och ateroskleros,Forskargrupper vid Lunds universitet,Cardiovascular Research - Immunity and Atherosclerosis,Lund University Research Groups
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- Khan, Faisel (author)
- University of Dundee
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- Colhoun, Helen M (author)
- University of Edinburgh
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- Palombo, Carlo (author)
- University of Pisa
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- Parker, Kim H (author)
- Imperial College London
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- Shore, Angela C (author)
- University of Exeter
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(creator_code:org_t)
- English.
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In: ESC Heart Failure. - 2055-5822.
- Related links:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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Abstract
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- AIMS: Parameters derived from reservoir-excess pressure analysis have been demonstrated to predict cardiovascular events. Thus, altered reservoir-excess pressure parameters could have a detrimental effect on highly-perfused organs like the heart. We aimed to cross-sectionally determine whether reservoir-excess pressure parameters were associated with N-terminal pro-brain-type natriuretic peptide (NT-proBNP) in older adults.METHODS: We studied 868 older adults with diverse cardiovascular risk. Reservoir-excess pressure parameters were obtained through radial artery tonometry including reservoir pressure integral, peak reservoir pressure, excess pressure integral (INTXSP), systolic rate constant (SRC) and diastolic rate constant (DRC). Plasma levels of NT-proBNP, as a biomarker of cardiac overload, were analysed by the Proximity Extension Assay technology.RESULTS: Multivariable linear regression analyses revealed that all reservoir-excess pressure parameters studied were associated with NT-proBNP after adjusting for age and sex. After further adjustments for conventional cardiovascular risk factors, INTXSP [β = 0.191 (95% confidence interval, CI: 0.099, 0.283), P < 0.001], SRC [β = -0.080 (95% CI: -0.141, -0.019), P = 0.010] and DRC [β = 0.138 (95% CI: 0.073, 0.202), P < 0.001] remained associated with NT-proBNP. Sensitivity analysis found that there were occasions where the association between SRC and NT-proBNP was attenuated, but both INTXSP and DRC remained consistently associated with NT-proBNP.CONCLUSIONS: The observed associations between reservoir-excess pressure parameters and NT-proBNP suggest that altered reservoir-excess pressure parameters may reflect an increased load inflicted on the left ventricular cardiomyocytes and could have a potential to be utilized in the clinical setting for cardiovascular risk stratification.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
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- art (subject category)
- ref (subject category)
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- By the author/editor
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Aizawa, Kunihiko
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Hughes, Alun D
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Casanova, France ...
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Gooding, Kim M
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Gates, Phillip E
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Mawson, David M
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show more...
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Williams, Jennif ...
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Goncalves, Isabe ...
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Nilsson, Jan
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Khan, Faisel
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Colhoun, Helen M
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Palombo, Carlo
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Parker, Kim H
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Shore, Angela C
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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ESC Heart Failur ...
- By the university
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Lund University