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Density of Sphingos...
Density of Sphingosine-1-Phosphate Receptors Is Altered in Cortical Nerve-Terminals of Insulin-Resistant Goto-Kakizaki Rats and Diet-Induced Obese Mice
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- Skoug, Cecilia (författare)
- Lund University,Lunds universitet,Diabetes och hjärnans funktion,Forskargrupper vid Lunds universitet,Diabetes and Brain Function,Lund University Research Groups
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- Erdogan, Hüseyin (författare)
- Lund University
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- Vanherle, Lotte (författare)
- Lund University,Lunds universitet,Vaskulär biologi,Forskargrupper vid Lunds universitet,Vascular Biology,Lund University Research Groups
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- Vieira, João P.P. (författare)
- Lund University
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- Matthes, Frank (författare)
- Lund University,Lunds universitet,Vaskulär biologi,Forskargrupper vid Lunds universitet,Kardiovaskulär forskning - translationella studier,Vascular Biology,Lund University Research Groups,Cardiovascular Research - Translational Studies
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- Eliasson, Lena (författare)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Diabetes - öcellsexocytos,Forskargrupper vid Lunds universitet,Department of Clinical Sciences, Malmö,Faculty of Medicine,Diabetes - Islet Cell Exocytosis,Lund University Research Groups,Skåne University Hospital
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- Meissner, Anja (författare)
- Lund University,Lunds universitet,Kansli för experimentell medicinsk vetenskap,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Vaskulär biologi,Forskargrupper vid Lunds universitet,WCMM- Wallenberg center för molekylär medicinsk forskning,Department Office of Experimental Medical Science,Department of Experimental Medical Science,Faculty of Medicine,Vascular Biology,Lund University Research Groups,WCMM-Wallenberg Centre for Molecular Medicine,University of Augsburg
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- Duarte, João M.N. (författare)
- Lund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Diabetes och hjärnans funktion,Forskargrupper vid Lunds universitet,WCMM- Wallenberg center för molekylär medicinsk forskning,Department of Experimental Medical Science,Faculty of Medicine,Diabetes and Brain Function,Lund University Research Groups,WCMM-Wallenberg Centre for Molecular Medicine
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(creator_code:org_t)
- 2023
- 2023
- Engelska.
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Ingår i: Neurochemical Research. - 0364-3190.
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Sphingosine-1-phosphate (S1P) is a phosphosphingolipid with pleiotropic biological functions. S1P acts as an intracellular second messenger, as well as extracellular ligand to five G-protein coupled receptors (S1PR1-5). In the brain, S1P regulates neuronal proliferation, apoptosis, synaptic activity and neuroglia activation. Moreover, S1P metabolism alterations have been reported in neurodegenerative disorders. We have previously reported that S1PRs are present in nerve terminals, exhibiting distinct sub-synaptic localization and neuromodulation actions. Since type 2 diabetes (T2D) causes synaptic dysfunction, we hypothesized that S1P signaling is modified in nerve terminals. In this study, we determined the density of S1PRs in cortical synaptosomes from insulin-resistant Goto-Kakizaki (GK) rats and Wistar controls, and from mice fed a high-fat diet (HFD) and low-fat-fed controls. Relative to their controls, GK rats showed similar cortical S1P concentration despite higher S1P levels in plasma, yet lower density of S1PR1, S1PR2 and S1PR4 in nerve-terminal-enriched membranes. HFD-fed mice exhibited increased plasma and cortical concentrations of S1P, and decreased density of S1PR1 and S1PR4. These findings point towards altered S1P signaling in synapses of insulin resistance and diet-induced obesity models, suggesting a role of S1P signaling in T2D-associated synaptic dysfunction.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Nyckelord
- Diabetes
- Neuromodulation
- Obesity
- Sphingosine
- Synaptosomes
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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