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A locus on 19p13 mo...
A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor-negative breast cancer in the general population
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Antoniou, Antonis C. (author)
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Wang, Xianshu (author)
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Fredericksen, Zachary S. (author)
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show more...
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McGuffog, Lesley (author)
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Tarrell, Robert (author)
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Sinilnikova, Olga M. (author)
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Healey, Sue (author)
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Morrison, Jonathan (author)
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Kartsonaki, Christiana (author)
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Lesnick, Timothy (author)
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Ghoussaini, Maya (author)
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Barrowdale, Daniel (author)
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Peock, Susan (author)
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Cook, Margaret (author)
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Oliver, Clare (author)
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Frost, Debra (author)
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Eccles, Diana (author)
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Evans, D. Gareth (author)
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Eeles, Ros (author)
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Izatt, Louise (author)
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Chu, Carol (author)
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Douglas, Fiona (author)
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Paterson, Joan (author)
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Stoppa-Lyonnet, Dominique (author)
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Houdayer, Claude (author)
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Mazoyer, Sylvie (author)
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Giraud, Sophie (author)
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Lasset, Christine (author)
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Remenieras, Audrey (author)
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Caron, Olivier (author)
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Hardouin, Agnes (author)
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Berthet, Pascaline (author)
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Hogervorst, Frans B. L. (author)
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Rookus, Matti A. (author)
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Jager, Agnes (author)
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van den Ouweland, Ans (author)
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Hoogerbrugge, Nicoline (author)
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van der Luijt, Rob B. (author)
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Meijers-Heijboer, Hanne (author)
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Garcia, Encarna B. Gomez (author)
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Devilee, Peter (author)
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Vreeswijk, Maaike P. G. (author)
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Lubinski, Jan (author)
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Jakubowska, Anna (author)
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Gronwald, Jacek (author)
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Huzarski, Tomasz (author)
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Byrski, Tomasz (author)
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Gorski, Bohdan (author)
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Cybulski, Cezary (author)
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Spurdle, Amanda B. (author)
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Holland, Helene (author)
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Goldgar, David E. (author)
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John, Esther M. (author)
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Hopper, John L. (author)
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Southey, Melissa (author)
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Buys, Saundra S. (author)
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Daly, Mary B. (author)
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Terry, Mary-Beth (author)
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Schmutzler, Rita K. (author)
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Wappenschmidt, Barbara (author)
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Engel, Christoph (author)
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Meindl, Alfons (author)
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Preisler-Adams, Sabine (author)
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Arnold, Norbert (author)
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Niederacher, Dieter (author)
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Sutter, Christian (author)
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Domchek, Susan M. (author)
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Nathanson, Katherine L. (author)
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Rebbeck, Timothy (author)
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Blum, Joanne L. (author)
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Piedmonte, Marion (author)
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Rodriguez, Gustavo C. (author)
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Wakeley, Katie (author)
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Boggess, John F. (author)
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Basil, Jack (author)
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Blank, Stephanie V. (author)
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Friedman, Eitan (author)
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Kaufman, Bella (author)
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Laitman, Yael (author)
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Milgrom, Roni (author)
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Andrulis, Irene L. (author)
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Glendon, Gord (author)
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Ozcelik, Hilmi (author)
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Kirchhoff, Tomas (author)
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Vijai, Joseph (author)
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Gaudet, Mia M. (author)
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Altshuler, David (author)
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Guiducci, Candace (author)
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- Loman, Niklas (author)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Harbst, Katja (author)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Rantala, Johanna (author)
- Karolinska Institutet
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- Ehrencrona, Hans (author)
- Uppsala universitet,Uppsala University,Institutionen för genetik och patologi
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Gerdes, Anne-Marie (author)
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Thomassen, Mads (author)
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Sunde, Lone (author)
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Peterlongo, Paolo (author)
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Manoukian, Siranoush (author)
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Bonanni, Bernardo (author)
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Viel, Alessandra (author)
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Radice, Paolo (author)
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Caldes, Trinidad (author)
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de la Hoya, Miguel (author)
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Singer, Christian F. (author)
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Fink-Retter, Anneliese (author)
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Greene, Mark H. (author)
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Mai, Phuong L. (author)
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Loud, Jennifer T. (author)
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Guidugli, Lucia (author)
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Lindor, Noralane M. (author)
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Hansen, Thomas V. O. (author)
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Nielsen, Finn C. (author)
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Blanco, Ignacio (author)
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Lazaro, Conxi (author)
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Garber, Judy (author)
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Ramus, Susan J. (author)
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Gayther, Simon A. (author)
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Phelan, Catherine (author)
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Narod, Stephen (author)
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Szabo, Csilla I. (author)
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Benitez, Javier (author)
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Osorio, Ana (author)
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Nevanlinna, Heli (author)
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Heikkinen, Tuomas (author)
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Caligo, Maria A. (author)
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Beattie, Mary S. (author)
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Hamann, Ute (author)
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Godwin, Andrew K. (author)
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Montagna, Marco (author)
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Casella, Cinzia (author)
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Neuhausen, Susan L. (author)
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Karlan, Beth Y. (author)
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Tung, Nadine (author)
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Toland, Amanda E. (author)
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Weitzel, Jeffrey (author)
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Olopade, Olofunmilayo (author)
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Simard, Jacques (author)
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Soucy, Penny (author)
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Rubinstein, Wendy S. (author)
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Arason, Adalgeir (author)
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Rennert, Gad (author)
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Martin, Nicholas G. (author)
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Montgomery, Grant W. (author)
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Chang-Claude, Jenny (author)
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Flesch-Janys, Dieter (author)
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Brauch, Hiltrud (author)
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Severi, Gianluca (author)
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Baglietto, Laura (author)
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Cox, Angela (author)
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Cross, Simon S. (author)
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Miron, Penelope (author)
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Gerty, Sue M. (author)
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Tapper, William (author)
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Yannoukakos, Drakoulis (author)
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Fountzilas, George (author)
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Fasching, Peter A. (author)
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Beckmann, Matthias W. (author)
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Silva, Isabel dos Santos (author)
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Peto, Julian (author)
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Lambrechts, Diether (author)
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Paridaens, Robert (author)
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Ruediger, Thomas (author)
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Foersti, Asta (author)
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Winqvist, Robert (author)
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Pylkaes, Katri (author)
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Diasio, Robert B. (author)
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Lee, Adam M. (author)
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Eckel-Passow, Jeanette (author)
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Vachon, Celine (author)
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Blows, Fiona (author)
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Driver, Kristy (author)
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Dunning, Alison (author)
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Pharoah, Paul P. D. (author)
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Offit, Kenneth (author)
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Pankratz, V. Shane (author)
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Hakonarson, Hakon (author)
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Chenevix-Trench, Georgia (author)
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Easton, Douglas F. (author)
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Couch, Fergus J. (author)
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(creator_code:org_t)
- 2010-09-19
- 2010
- English.
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In: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 42:10, s. 885-892
- Related links:
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http://dx.doi.org/10... (free)
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http://www.ncbi.nlm.... (free)
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http://dx.doi.org/10...
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https://cdr.lib.unc....
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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http://kipublication...
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https://urn.kb.se/re...
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Abstract
Subject headings
Close
- Germline BRCA1 mutations predispose to breast cancer. To identify genetic modifiers of this risk, we performed a genome-wide association study in 1,193 individuals with BRCA1 mutations who were diagnosed with invasive breast cancer under age 40 and 1,190 BRCA1 carriers without breast cancer diagnosis over age 35. We took forward 96 SNPs for replication in another 5,986 BRCA1 carriers (2,974 individuals with breast cancer and 3,012 unaffected individuals). Five SNPs on 19p13 were associated with breast cancer risk (P-trend = 2.3 x 10(-9) to Ptrend = 3.9 x 10(-7)), two of which showed independent associations (rs8170, hazard ratio (HR) = 1.26, 95% CI 1.17-1.35; rs2363956 HR = 0.84, 95% CI 0.80-0.89). Genotyping these SNPs in 6,800 population-based breast cancer cases and 6,613 controls identified a similar association with estrogen receptor-negative breast cancer (rs2363956 per-allele odds ratio (OR) = 0.83, 95% CI 0.75-0.92, P-trend = 0.0003) and an association with estrogen receptor-positive disease in the opposite direction (OR = 1.07, 95% CI 1.01-1.14, P-trend = 0.016). The five SNPs were also associated with triple-negative breast cancer in a separate study of 2,301 triple-negative cases and 3,949 controls (Ptrend = 1 x 10(-7) to Ptrend = 8 x 10(-5); rs2363956 per-allele OR = 0.80, 95% CI 0.74-0.87, P-trend = 1.1 x 10(-7)).
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Mutation
- Humans
- Genotype
- Genetic Predisposition to Disease
- Female
- Pair 19
- Human
- Chromosomes
- Case-Control Studies
- Breast Neoplasms
- Adult
- BRCA1 Protein
- Polymorphism
- Single Nucleotide
- Receptor
- erbB-2
- Receptors
- Estrogen
- Progesterone
- MEDICINE
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Antoniou, Antoni ...
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Wang, Xianshu
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Fredericksen, Za ...
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McGuffog, Lesley
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Tarrell, Robert
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Sinilnikova, Olg ...
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show more...
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Healey, Sue
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Morrison, Jonath ...
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Kartsonaki, Chri ...
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Lesnick, Timothy
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Ghoussaini, Maya
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Barrowdale, Dani ...
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Peock, Susan
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Cook, Margaret
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Oliver, Clare
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Frost, Debra
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Eccles, Diana
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Evans, D. Gareth
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Eeles, Ros
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Izatt, Louise
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Chu, Carol
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Douglas, Fiona
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Paterson, Joan
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Stoppa-Lyonnet, ...
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Houdayer, Claude
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Mazoyer, Sylvie
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Giraud, Sophie
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Lasset, Christin ...
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Remenieras, Audr ...
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Caron, Olivier
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Hardouin, Agnes
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Berthet, Pascali ...
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Hogervorst, Fran ...
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Rookus, Matti A.
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Jager, Agnes
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van den Ouweland ...
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Hoogerbrugge, Ni ...
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van der Luijt, R ...
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Meijers-Heijboer ...
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Garcia, Encarna ...
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Devilee, Peter
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Vreeswijk, Maaik ...
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Lubinski, Jan
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Jakubowska, Anna
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Gronwald, Jacek
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Huzarski, Tomasz
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Byrski, Tomasz
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Gorski, Bohdan
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Cybulski, Cezary
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Spurdle, Amanda ...
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Holland, Helene
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Goldgar, David E ...
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John, Esther M.
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Hopper, John L.
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Southey, Melissa
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Buys, Saundra S.
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Daly, Mary B.
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Terry, Mary-Beth
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Schmutzler, Rita ...
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Wappenschmidt, B ...
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Engel, Christoph
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Meindl, Alfons
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Preisler-Adams, ...
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Arnold, Norbert
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Niederacher, Die ...
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Sutter, Christia ...
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Domchek, Susan M ...
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Nathanson, Kathe ...
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Rebbeck, Timothy
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Blum, Joanne L.
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Piedmonte, Mario ...
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Rodriguez, Gusta ...
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Wakeley, Katie
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Boggess, John F.
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Basil, Jack
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Blank, Stephanie ...
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Friedman, Eitan
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Kaufman, Bella
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Laitman, Yael
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Milgrom, Roni
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Andrulis, Irene ...
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Glendon, Gord
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Ozcelik, Hilmi
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Kirchhoff, Tomas
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Vijai, Joseph
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Gaudet, Mia M.
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Altshuler, David
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Guiducci, Candac ...
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Loman, Niklas
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Harbst, Katja
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Rantala, Johanna
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Ehrencrona, Hans
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Gerdes, Anne-Mar ...
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Thomassen, Mads
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Sunde, Lone
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Peterlongo, Paol ...
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Manoukian, Siran ...
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Bonanni, Bernard ...
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Viel, Alessandra
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Radice, Paolo
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Caldes, Trinidad
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de la Hoya, Migu ...
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Singer, Christia ...
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Fink-Retter, Ann ...
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Greene, Mark H.
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Mai, Phuong L.
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Loud, Jennifer T ...
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Guidugli, Lucia
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Lindor, Noralane ...
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Hansen, Thomas V ...
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Nielsen, Finn C.
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Blanco, Ignacio
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Lazaro, Conxi
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Garber, Judy
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Ramus, Susan J.
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Gayther, Simon A ...
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Phelan, Catherin ...
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Narod, Stephen
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Szabo, Csilla I.
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Benitez, Javier
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Osorio, Ana
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Nevanlinna, Heli
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Heikkinen, Tuoma ...
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Caligo, Maria A.
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Beattie, Mary S.
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Hamann, Ute
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Godwin, Andrew K ...
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Montagna, Marco
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Casella, Cinzia
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Neuhausen, Susan ...
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Karlan, Beth Y.
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Tung, Nadine
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Toland, Amanda E ...
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Weitzel, Jeffrey
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Olopade, Olofunm ...
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Simard, Jacques
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Soucy, Penny
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Rubinstein, Wend ...
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Arason, Adalgeir
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Rennert, Gad
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Martin, Nicholas ...
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Montgomery, Gran ...
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Chang-Claude, Je ...
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Flesch-Janys, Di ...
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Brauch, Hiltrud
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Severi, Gianluca
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Baglietto, Laura
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Cox, Angela
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Cross, Simon S.
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Miron, Penelope
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Gerty, Sue M.
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Tapper, William
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Yannoukakos, Dra ...
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Fountzilas, Geor ...
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Fasching, Peter ...
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Beckmann, Matthi ...
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Silva, Isabel do ...
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Peto, Julian
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Lambrechts, Diet ...
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Paridaens, Rober ...
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Ruediger, Thomas
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Foersti, Asta
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Winqvist, Robert
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Pylkaes, Katri
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Diasio, Robert B ...
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Lee, Adam M.
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Eckel-Passow, Je ...
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Vachon, Celine
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Blows, Fiona
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Driver, Kristy
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Dunning, Alison
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Pharoah, Paul P. ...
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Offit, Kenneth
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Pankratz, V. Sha ...
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Hakonarson, Hako ...
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Chenevix-Trench, ...
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Easton, Douglas ...
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Couch, Fergus J.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Nature Genetics
- By the university
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Lund University
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Karolinska Institutet
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Uppsala University